ES2960880T3 - Terapia génica mediada por AAV que restaura el gen de la otoferlina - Google Patents
Terapia génica mediada por AAV que restaura el gen de la otoferlina Download PDFInfo
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- ES2960880T3 ES2960880T3 ES20701951T ES20701951T ES2960880T3 ES 2960880 T3 ES2960880 T3 ES 2960880T3 ES 20701951 T ES20701951 T ES 20701951T ES 20701951 T ES20701951 T ES 20701951T ES 2960880 T3 ES2960880 T3 ES 2960880T3
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| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| US12233136B2 (en) | 2018-04-27 | 2025-02-25 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
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| BR112022016596A2 (pt) | 2020-02-21 | 2022-11-16 | Akouos Inc | Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano |
| IL295741A (en) | 2020-04-01 | 2022-10-01 | Univ Florida | Dual aav-myo7a vectors with improved safety for the treatment of ush1b |
| CA3197592A1 (en) * | 2020-11-06 | 2022-05-12 | Steven Pennock | Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss |
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| US20250295716A1 (en) * | 2021-09-10 | 2025-09-25 | Institut Pasteur | Dual recombinant aav8 vector system encoding isoform 5 of otoferlin and uses thereof |
| EP4527933A4 (en) * | 2022-05-17 | 2025-12-24 | Eye & Ent Hospital Of Fudan Univ | DUAL-SUPPORT SYSTEM FOR THE TREATMENT OF HEARING LOSS, AND ITS USE |
| CN117106824B (zh) * | 2022-05-17 | 2025-09-02 | 上海佑音医药生物科技有限公司 | 一种治疗听力损伤的双载体系统及其应用 |
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| JP4810062B2 (ja) | 2001-12-17 | 2011-11-09 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス（ａａｖ）血清型８の配列 |
| WO2003059396A1 (en) | 2002-01-11 | 2003-07-24 | Sergei Zolotukhin | Adiponectin gene therapy |
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| WO2017100791A1 (en) | 2015-12-11 | 2017-06-15 | Massachusetts Eye And Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| EP3510161A4 (en) * | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING NON-AGE-ASSOCIATED HEARING DEFICIENCY IN A HUMAN SUBJECT |
| CN110892062A (zh) | 2017-05-05 | 2020-03-17 | 佛罗里达大学研究基金会 | 表达耳畸蛋白的组合物和方法 |
| KR20200126997A (ko) | 2018-02-22 | 2020-11-09 | 아카우오스, 인크. | 인간 대상체에서의 비-노화-관련 청각 손상의 치료를 위한 조성물 및 방법 |
| US11660353B2 (en) * | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
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