ES2951323R1 - Proceso para preparar (3alfa,5alfa)-3-hidroxi-3-metil-pregnan-20-ona (ganaxolona) - Google Patents
Proceso para preparar (3alfa,5alfa)-3-hidroxi-3-metil-pregnan-20-ona (ganaxolona)Info
- Publication number
- ES2951323R1 ES2951323R1 ES202390011A ES202390011A ES2951323R1 ES 2951323 R1 ES2951323 R1 ES 2951323R1 ES 202390011 A ES202390011 A ES 202390011A ES 202390011 A ES202390011 A ES 202390011A ES 2951323 R1 ES2951323 R1 ES 2951323R1
- Authority
- ES
- Spain
- Prior art keywords
- ganaxolone
- 3alpha
- 5alpha
- pregnan
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PGTVWKLGGCQMBR-FLBATMFCSA-N Ganaxolone Chemical compound C([C@@H]1CC2)[C@](C)(O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 PGTVWKLGGCQMBR-FLBATMFCSA-N 0.000 title 2
- 229950006567 ganaxolone Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102020000021316A IT202000021316A1 (it) | 2020-09-09 | 2020-09-09 | PROCESSO PER LA PREPARAZIONE DI (3α,5α)-3-IDROSSI-3-METIL-PREGNAN-20-ONE (GANAXOLONE) |
| PCT/IB2021/058149 WO2022053937A1 (en) | 2020-09-09 | 2021-09-08 | PROCESS FOR PREPARING (3α,5α)-3-HYDROX Y -3-METHYL-PREGNAN -20- ONE (GANAXOLONE) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ES2951323A2 ES2951323A2 (es) | 2023-10-19 |
| ES2951323R1 true ES2951323R1 (es) | 2024-03-21 |
| ES2951323A9 ES2951323A9 (es) | 2024-06-20 |
Family
ID=73643165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES202390011A Pending ES2951323R1 (es) | 2020-09-09 | 2021-09-08 | Proceso para preparar (3alfa,5alfa)-3-hidroxi-3-metil-pregnan-20-ona (ganaxolona) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230322844A1 (es) |
| CN (1) | CN116057065A (es) |
| CA (1) | CA3191955A1 (es) |
| CH (1) | CH719172B1 (es) |
| DE (1) | DE112021003885T5 (es) |
| ES (1) | ES2951323R1 (es) |
| GB (1) | GB2614494B (es) |
| IT (1) | IT202000021316A1 (es) |
| WO (1) | WO2022053937A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115028535A (zh) * | 2022-06-28 | 2022-09-09 | 浙江微通催化新材料有限公司 | 一种四丙基高钌酸铵的制备方法 |
| CN118530293A (zh) * | 2024-05-24 | 2024-08-23 | 湖北武当安泰药业有限公司 | 一种表雄酮的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011019821A2 (en) * | 2009-08-13 | 2011-02-17 | Marinus Pharmaceuticals, Inc. | METHOD FOR MAKING 3α-HYDROXY, 3β- METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) |
| WO2016061527A1 (en) * | 2014-10-16 | 2016-04-21 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953429A (en) | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
| EP0246453A3 (en) | 1986-04-18 | 1989-09-06 | General Signal Corporation | Novel multiple-processing and contamination-free plasma etching system |
| EP2464753A4 (en) | 2009-08-12 | 2013-12-11 | Harvard College | BIO RECOGNITION METHOD AND COMPOSITIONS |
| IT201800009683A1 (it) | 2018-10-22 | 2020-04-22 | Ind Chimica Srl | Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) |
-
2020
- 2020-09-09 IT IT102020000021316A patent/IT202000021316A1/it unknown
-
2021
- 2021-09-08 CA CA3191955A patent/CA3191955A1/en active Pending
- 2021-09-08 US US18/024,612 patent/US20230322844A1/en active Pending
- 2021-09-08 CN CN202180061585.6A patent/CN116057065A/zh active Pending
- 2021-09-08 WO PCT/IB2021/058149 patent/WO2022053937A1/en active Application Filing
- 2021-09-08 ES ES202390011A patent/ES2951323R1/es active Pending
- 2021-09-08 DE DE112021003885.0T patent/DE112021003885T5/de active Pending
- 2021-09-08 CH CH000275/2023A patent/CH719172B1/it unknown
- 2021-09-08 GB GB2305045.3A patent/GB2614494B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011019821A2 (en) * | 2009-08-13 | 2011-02-17 | Marinus Pharmaceuticals, Inc. | METHOD FOR MAKING 3α-HYDROXY, 3β- METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) |
| WO2016061527A1 (en) * | 2014-10-16 | 2016-04-21 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
Non-Patent Citations (1)
| Title |
|---|
| HOGENKAMP, D.J. ET AL. . Synthesis and in Vitro Activity of 3b-Substituted-3a-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor. Journal of the Medicinal Chemistry, 03.01.1997, Vol. 40, Páginas 61-72 1520-4804; 0022-2623 (en línea), (DOI: 10.1021/jm960021x) Ver página 61, resumen; página 62, esquema 1; página 63, esquema 5; página 79; página 64, tabla 1, compuesto 6; página 67, sección experimental. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CH719172B1 (it) | 2024-09-30 |
| DE112021003885T5 (de) | 2023-05-04 |
| CN116057065A (zh) | 2023-05-02 |
| US20230322844A1 (en) | 2023-10-12 |
| ES2951323A9 (es) | 2024-06-20 |
| GB202305045D0 (en) | 2023-05-17 |
| GB2614494B (en) | 2024-06-26 |
| ES2951323A2 (es) | 2023-10-19 |
| GB2614494A (en) | 2023-07-05 |
| CA3191955A1 (en) | 2022-03-17 |
| WO2022053937A1 (en) | 2022-03-17 |
| IT202000021316A1 (it) | 2022-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA2A | Patent application published |
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| EC2A | Search report published |
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