ES2942890T3 - Composiciones y procedimientos para suministro, expresión y modulación dirigidos de ácidos ribonucleicos codificantes en tejidos - Google Patents

Composiciones y procedimientos para suministro, expresión y modulación dirigidos de ácidos ribonucleicos codificantes en tejidos Download PDF

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ES2942890T3
ES2942890T3 ES18792572T ES18792572T ES2942890T3 ES 2942890 T3 ES2942890 T3 ES 2942890T3 ES 18792572 T ES18792572 T ES 18792572T ES 18792572 T ES18792572 T ES 18792572T ES 2942890 T3 ES2942890 T3 ES 2942890T3
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mrna
cells
sequence
mirna
cancer
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Romain Micol
Slawomir Antoszczyk
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Combined Therapeutics Inc
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Combined Therapeutics Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/763Herpes virus
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates
    • C12N2800/107Plasmid DNA for vertebrates for mammalian
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES18792572T 2017-09-07 2018-09-06 Composiciones y procedimientos para suministro, expresión y modulación dirigidos de ácidos ribonucleicos codificantes en tejidos Active ES2942890T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1714430.4A GB201714430D0 (en) 2017-09-07 2017-09-07 Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
US201862632056P 2018-02-19 2018-02-19
PCT/US2018/049772 WO2019051100A1 (en) 2017-09-07 2018-09-06 COMPOSITIONS AND METHODS FOR TARGETED CODING ADMINISTRATION, EXPRESSION AND MODULATION OF RIBONUCLEIC ACIDS IN TISSUE

Publications (1)

Publication Number Publication Date
ES2942890T3 true ES2942890T3 (es) 2023-06-07

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ES18792572T Active ES2942890T3 (es) 2017-09-07 2018-09-06 Composiciones y procedimientos para suministro, expresión y modulación dirigidos de ácidos ribonucleicos codificantes en tejidos

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US (3) US11359212B2 (https=)
EP (2) EP3678673B1 (https=)
JP (4) JP2020533411A (https=)
KR (1) KR102741572B1 (https=)
CN (1) CN111212650A (https=)
AU (1) AU2018328289B2 (https=)
CA (1) CA3074293A1 (https=)
ES (1) ES2942890T3 (https=)
GB (1) GB201714430D0 (https=)
MX (2) MX2020002568A (https=)
PL (1) PL3678673T3 (https=)
PT (1) PT3678673T (https=)
RU (1) RU2020112990A (https=)
WO (1) WO2019051100A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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AU2018316166A1 (en) 2017-08-07 2020-02-06 The Regents Of The University Of California Platform for generating safe cell therapeutics
GB201714430D0 (en) * 2017-09-07 2017-10-25 Micol Romain Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
IL295724A (en) 2020-02-21 2022-10-01 Combined Therapeutics Inc Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
IL300247A (en) 2020-07-31 2023-03-01 Combined Therapeutics Inc Compositions and methods for improving vaccination
CA3171589A1 (en) 2021-05-03 2022-11-03 Moritz THRAN Improved nucleic acid sequence for cell type specific expression
CN113444744A (zh) * 2021-06-28 2021-09-28 北京鼎成肽源生物技术有限公司 一种用于基因编辑NK细胞的mRNA模板及构建方法、mRNA的体外转录方法和应用
CN114107347B (zh) * 2021-11-24 2022-10-28 中国人民解放军空军军医大学 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用

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Publication number Publication date
RU2020112990A (ru) 2021-10-07
MX2020002568A (es) 2020-09-18
EP3678673B1 (en) 2023-01-25
AU2018328289B2 (en) 2025-07-10
CN111212650A (zh) 2020-05-29
JP2023159160A (ja) 2023-10-31
KR20200104282A (ko) 2020-09-03
JP2024059656A (ja) 2024-05-01
RU2020130763A (ru) 2022-03-21
PL3678673T3 (pl) 2023-07-10
RU2020130763A3 (https=) 2022-03-22
EP3678673A1 (en) 2020-07-15
RU2020112990A3 (https=) 2022-03-05
US11359212B2 (en) 2022-06-14
MX2020008606A (es) 2020-09-21
US20220220506A1 (en) 2022-07-14
US12195746B2 (en) 2025-01-14
EP4218770A2 (en) 2023-08-02
AU2018328289A1 (en) 2020-03-19
GB201714430D0 (en) 2017-10-25
JP2024122983A (ja) 2024-09-10
US20250129383A1 (en) 2025-04-24
CA3074293A1 (en) 2019-03-14
JP2020533411A (ja) 2020-11-19
WO2019051100A1 (en) 2019-03-14
PT3678673T (pt) 2023-04-24
US20200255863A1 (en) 2020-08-13
KR102741572B1 (ko) 2024-12-10
EP4218770A3 (en) 2023-08-09

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