ES2941036T3 - Composición tópica oftálmica que comprende ácido dobesílico para el tratamiento de enfermedades del segmento posterior del ojo - Google Patents
Composición tópica oftálmica que comprende ácido dobesílico para el tratamiento de enfermedades del segmento posterior del ojo Download PDFInfo
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- ES2941036T3 ES2941036T3 ES18811023T ES18811023T ES2941036T3 ES 2941036 T3 ES2941036 T3 ES 2941036T3 ES 18811023 T ES18811023 T ES 18811023T ES 18811023 T ES18811023 T ES 18811023T ES 2941036 T3 ES2941036 T3 ES 2941036T3
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- acid
- salt
- pharmaceutically acceptable
- dobesylic
- eye
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- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- KICVIQZBYBXLQD-UHFFFAOYSA-M sodium;2,5-dihydroxybenzenesulfonate Chemical compound [Na+].OC1=CC=C(O)C(S([O-])(=O)=O)=C1 KICVIQZBYBXLQD-UHFFFAOYSA-M 0.000 description 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 description 1
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 210000001745 uvea Anatomy 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382832 | 2017-12-04 | ||
| PCT/EP2018/082999 WO2019110416A1 (en) | 2017-12-04 | 2018-11-29 | Ophthalmic topical composition comprising dobesilic acid for treating diseases of the posterior segment of the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2941036T3 true ES2941036T3 (es) | 2023-05-16 |
Family
ID=60673756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18811023T Active ES2941036T3 (es) | 2017-12-04 | 2018-11-29 | Composición tópica oftálmica que comprende ácido dobesílico para el tratamiento de enfermedades del segmento posterior del ojo |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20200390729A1 (enExample) |
| EP (1) | EP3720428B1 (enExample) |
| JP (1) | JP2021505554A (enExample) |
| KR (1) | KR102756155B1 (enExample) |
| CN (1) | CN111542316A (enExample) |
| AU (1) | AU2018378981B2 (enExample) |
| BR (1) | BR112020011160A2 (enExample) |
| CA (1) | CA3083835A1 (enExample) |
| CL (1) | CL2020001426A1 (enExample) |
| DK (1) | DK3720428T3 (enExample) |
| ES (1) | ES2941036T3 (enExample) |
| FI (1) | FI3720428T3 (enExample) |
| HR (1) | HRP20230319T1 (enExample) |
| HU (1) | HUE061852T2 (enExample) |
| MA (1) | MA50991B1 (enExample) |
| MX (1) | MX2020005809A (enExample) |
| MY (1) | MY205498A (enExample) |
| PH (1) | PH12020550722A1 (enExample) |
| PL (1) | PL3720428T3 (enExample) |
| PT (1) | PT3720428T (enExample) |
| SG (1) | SG11202004940VA (enExample) |
| SI (1) | SI3720428T1 (enExample) |
| WO (1) | WO2019110416A1 (enExample) |
| ZA (1) | ZA202003944B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202300017430A1 (it) * | 2023-08-22 | 2025-02-22 | Service Biotech srl | Soluzione oftalmica in forma di collirio contenente una isoforma umana ricombinante di manganese superossido dismutasi (rmnsod) per la cura di patologie dell’occhio |
| CN117257963B (zh) * | 2023-11-02 | 2024-07-16 | 广州准优生物科技有限公司 | 含脐带间充质干细胞外泌体的眼用药剂及其制备方法和用途 |
| CN117643573B (zh) * | 2024-01-29 | 2024-05-03 | 天津医科大学眼科医院 | 一种可递送药物至眼后节的纳米滴眼液及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE51421B1 (en) * | 1980-08-01 | 1986-12-24 | Smith & Nephew Ass | Ophthalmic compositions containing triamterene |
| US9198886B2 (en) * | 2006-08-16 | 2015-12-01 | Pedro Cuevas Sánchez | Use of 2,5-dihydroxybenzene for the treatment of ocular diseases |
| BR112014013041A2 (pt) * | 2011-11-30 | 2019-09-24 | Xigen Inflammation Ltd | uso de inibidores de peptídeos de permeação celular do curso de transdução de sinal de jnk para o tratamento da síndrome do olho seco |
| PT2777699T (pt) * | 2012-02-02 | 2017-07-07 | Invesfovea S L | Dietilamina-2,5-di-hidroxibenzenossulfonato para o tratamento de degeneração macular relacionada com a idade |
| EA201491643A1 (ru) * | 2012-03-05 | 2015-02-27 | Уэйн Стейт Юниверсити | Идентификация мутаций канал-опсина-2 (chop2) и способы применения |
| CA2871528A1 (en) * | 2012-04-24 | 2013-10-31 | Thrombogenics N.V. | Anti-pdgf-c antibodies |
| EP2875811A1 (en) * | 2013-11-26 | 2015-05-27 | Luis Antonio Outeirino Miguez | Use of dobesilate for treating ocular haemorrhages |
-
2018
- 2018-11-29 PL PL18811023.3T patent/PL3720428T3/pl unknown
- 2018-11-29 MA MA50991A patent/MA50991B1/fr unknown
- 2018-11-29 JP JP2020529733A patent/JP2021505554A/ja active Pending
- 2018-11-29 PT PT188110233T patent/PT3720428T/pt unknown
- 2018-11-29 KR KR1020207018983A patent/KR102756155B1/ko active Active
- 2018-11-29 US US16/770,027 patent/US20200390729A1/en active Pending
- 2018-11-29 SG SG11202004940VA patent/SG11202004940VA/en unknown
- 2018-11-29 EP EP18811023.3A patent/EP3720428B1/en active Active
- 2018-11-29 CA CA3083835A patent/CA3083835A1/en active Pending
- 2018-11-29 ES ES18811023T patent/ES2941036T3/es active Active
- 2018-11-29 HR HRP20230319TT patent/HRP20230319T1/hr unknown
- 2018-11-29 SI SI201830869T patent/SI3720428T1/sl unknown
- 2018-11-29 HU HUE18811023A patent/HUE061852T2/hu unknown
- 2018-11-29 BR BR112020011160-0A patent/BR112020011160A2/pt unknown
- 2018-11-29 MY MYPI2020002628A patent/MY205498A/en unknown
- 2018-11-29 DK DK18811023.3T patent/DK3720428T3/da active
- 2018-11-29 CN CN201880082202.1A patent/CN111542316A/zh active Pending
- 2018-11-29 MX MX2020005809A patent/MX2020005809A/es unknown
- 2018-11-29 FI FIEP18811023.3T patent/FI3720428T3/fi active
- 2018-11-29 AU AU2018378981A patent/AU2018378981B2/en active Active
- 2018-11-29 WO PCT/EP2018/082999 patent/WO2019110416A1/en not_active Ceased
-
2020
- 2020-05-27 PH PH12020550722A patent/PH12020550722A1/en unknown
- 2020-05-28 CL CL2020001426A patent/CL2020001426A1/es unknown
- 2020-06-29 ZA ZA2020/03944A patent/ZA202003944B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019110416A1 (en) | 2019-06-13 |
| MY205498A (en) | 2024-10-23 |
| PH12020550722A1 (en) | 2021-02-15 |
| AU2018378981A1 (en) | 2020-07-16 |
| KR102756155B1 (ko) | 2025-01-20 |
| DK3720428T3 (da) | 2023-03-20 |
| EP3720428B1 (en) | 2023-01-11 |
| MA50991A (fr) | 2020-10-14 |
| EP3720428A1 (en) | 2020-10-14 |
| BR112020011160A2 (pt) | 2020-11-17 |
| ZA202003944B (en) | 2022-12-21 |
| KR20200096569A (ko) | 2020-08-12 |
| HRP20230319T1 (hr) | 2023-05-12 |
| AU2018378981B2 (en) | 2024-10-24 |
| CN111542316A (zh) | 2020-08-14 |
| FI3720428T3 (fi) | 2023-03-30 |
| SI3720428T1 (sl) | 2023-05-31 |
| US20200390729A1 (en) | 2020-12-17 |
| CA3083835A1 (en) | 2019-06-13 |
| PL3720428T3 (pl) | 2023-05-08 |
| MX2020005809A (es) | 2020-08-20 |
| JP2021505554A (ja) | 2021-02-18 |
| SG11202004940VA (en) | 2020-06-29 |
| MA50991B1 (fr) | 2023-03-31 |
| HUE061852T2 (hu) | 2023-08-28 |
| PT3720428T (pt) | 2023-04-03 |
| CL2020001426A1 (es) | 2020-11-06 |
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