ES2940087T3 - Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) - Google Patents

Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) Download PDF

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Publication number
ES2940087T3
ES2940087T3 ES18742985T ES18742985T ES2940087T3 ES 2940087 T3 ES2940087 T3 ES 2940087T3 ES 18742985 T ES18742985 T ES 18742985T ES 18742985 T ES18742985 T ES 18742985T ES 2940087 T3 ES2940087 T3 ES 2940087T3
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cancer
fsps
fsp
cvp
fsm
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Spanish (es)
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Alfredo Nicosia
Elisa Scarselli
Guido Leoni
Armin Lahm
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Nouscom AG
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Nouscom AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES18742985T 2017-07-12 2018-07-12 Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) Active ES2940087T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17181026 2017-07-12
PCT/EP2018/069032 WO2019012082A1 (en) 2017-07-12 2018-07-12 UNIVERSAL VACCINE BASED ON SHARED TUMOR NEO-ANTIGENS FOR THE PREVENTION AND TREATMENT OF MICRO-SATELLITE INSTABILITY CANCER (MSI)

Publications (1)

Publication Number Publication Date
ES2940087T3 true ES2940087T3 (es) 2023-05-03

Family

ID=59366234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18742985T Active ES2940087T3 (es) 2017-07-12 2018-07-12 Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI)

Country Status (19)

Country Link
US (1) US11578109B2 (https=)
EP (1) EP3652606B1 (https=)
JP (1) JP7274223B2 (https=)
KR (1) KR102709778B1 (https=)
CN (1) CN111328420B (https=)
AU (1) AU2018298849B2 (https=)
BR (1) BR112020000590A2 (https=)
CA (1) CA3069047A1 (https=)
DK (1) DK3652606T5 (https=)
ES (1) ES2940087T3 (https=)
FI (1) FI3652606T3 (https=)
HU (1) HUE061840T2 (https=)
IL (1) IL271966B2 (https=)
MX (1) MX2020000413A (https=)
NZ (1) NZ759940A (https=)
PL (1) PL3652606T3 (https=)
PT (1) PT3652606T (https=)
SG (1) SG11202000250PA (https=)
WO (1) WO2019012082A1 (https=)

Families Citing this family (12)

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US20220349010A1 (en) * 2018-07-26 2022-11-03 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
CA3106564A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
IL280113B2 (en) 2018-07-26 2025-11-01 Curevac Netherlands B V Cancer vaccines for uterine cancer
WO2020022900A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for kidney cancer
IL321692A (en) 2018-07-26 2025-08-01 Curevac Netherlands B V Cancer vaccines for colorectal cancer
WO2020022903A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. ARID1A, CDKN2A, KMT2B, KMT2D, TP53 and PTEN VACCINES FOR CANCER
TWI852977B (zh) * 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
WO2020163802A1 (en) * 2019-02-07 2020-08-13 Arizona Board Of Regents On Behalf Of Arizona State University Cancer specific frameshift vaccines
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
US20230212243A1 (en) * 2020-05-12 2023-07-06 Institut Curie Neoantigenic Epitopes Associated with SF3B1 Mutations
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
JP2024516542A (ja) * 2021-04-06 2024-04-16 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム Mhcクラスiペプチドを含む方法および組成物

Family Cites Families (18)

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US5922315A (en) 1997-01-24 1999-07-13 Genetic Therapy, Inc. Adenoviruses having altered hexon proteins
WO2003087162A2 (en) * 2002-04-18 2003-10-23 Mtm Laboratories Ag Neopeptides and methods useful for detection and treatment of cancer
US20060160090A1 (en) * 2003-04-11 2006-07-20 Macina Robert A Composition splice variants and methods relating to cancer specific genes and proteins
CN1824325A (zh) * 2005-12-16 2006-08-30 武汉大学 人乳头病毒dna嵌合疫苗及制备方法和应用
KR101543622B1 (ko) * 2006-10-17 2015-08-11 온코세라피 사이언스 가부시키가이샤 Mphosph1 또는 depdc1 폴리펩티드를 발현하는 암에 대한 펩티드 백신
TW201102081A (en) * 2009-05-11 2011-01-16 Oncotherapy Science Inc TTK peptides and vaccines including the same
CA2758356C (en) 2009-05-29 2016-07-26 Morphosys Ag A collection of vh and vl pairs having favourable biophysical properties and methods for its use
SG10201502791YA (en) * 2010-04-09 2015-05-28 Oncotherapy Science Inc Cdca5 Peptides And Vaccines Including The Same
CA2830787C (en) * 2011-03-24 2019-11-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Dominant negative hsp110 mutant and its use in prognosing and treating cancers
JP5564730B2 (ja) * 2011-08-12 2014-08-06 オンコセラピー・サイエンス株式会社 Mphosph1ペプチドおよびそれを含むワクチン
JP5890769B2 (ja) * 2012-12-13 2016-03-22 ループレヒト−カルルス・ウニヴェルジテート・ハイデルベルクRuprecht−Karls−Universitaet Heidelberg がんの予防及び治療のためのmsi特異的なフレームシフトペプチド(fsp)
US9205140B2 (en) * 2012-12-13 2015-12-08 Ruprecht-Karls-Universität MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer
CN104853764B (zh) * 2012-12-13 2018-06-22 海德堡吕布莱希特-卡尔斯大学 用于预防和治疗癌症的msi-特异性移码肽(fsp)
US20140235456A1 (en) * 2012-12-17 2014-08-21 Virginia Tech Intellectual Properties, Inc. Methods and Compositions for Identifying Global Microsatellite Instability and for Characterizing Informative Microsatellite Loci
US11098367B2 (en) * 2014-01-27 2021-08-24 Yale University Methods of identifying patients responsive to immunotherapeutic strategies
IL294183B2 (en) 2015-05-20 2023-10-01 Dana Farber Cancer Inst Inc shared neoantigens
CN106350578A (zh) * 2015-07-13 2017-01-25 中国人民解放军第二军医大学 Ny-eso-1在微卫星不稳定性肠癌的诊断和治疗中的应用
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques

Also Published As

Publication number Publication date
IL271966B1 (en) 2024-09-01
SG11202000250PA (en) 2020-02-27
US20200222519A1 (en) 2020-07-16
KR20200029443A (ko) 2020-03-18
EP3652606A1 (en) 2020-05-20
FI3652606T3 (fi) 2023-03-16
RU2019144505A3 (https=) 2021-08-12
NZ759940A (en) 2023-07-28
DK3652606T3 (da) 2023-03-13
CA3069047A1 (en) 2019-01-17
DK3652606T5 (da) 2024-08-26
JP2020532288A (ja) 2020-11-12
EP3652606B1 (en) 2023-01-11
MX2020000413A (es) 2020-09-28
HUE061840T2 (hu) 2023-08-28
IL271966B2 (en) 2025-01-01
WO2019012082A1 (en) 2019-01-17
RU2019144505A (ru) 2021-08-12
AU2018298849A1 (en) 2020-01-02
KR102709778B1 (ko) 2024-09-26
US11578109B2 (en) 2023-02-14
CN111328420A (zh) 2020-06-23
IL271966A (en) 2020-02-27
JP7274223B2 (ja) 2023-05-16
PL3652606T3 (pl) 2023-04-24
PT3652606T (pt) 2023-03-16
WO2019012082A9 (en) 2019-05-02
BR112020000590A2 (pt) 2020-07-14
CN111328420B (zh) 2023-07-25
AU2018298849B2 (en) 2022-07-14

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