ES2927144T3 - Modelo de piel no biológica - Google Patents
Modelo de piel no biológica Download PDFInfo
- Publication number
- ES2927144T3 ES2927144T3 ES19758994T ES19758994T ES2927144T3 ES 2927144 T3 ES2927144 T3 ES 2927144T3 ES 19758994 T ES19758994 T ES 19758994T ES 19758994 T ES19758994 T ES 19758994T ES 2927144 T3 ES2927144 T3 ES 2927144T3
- Authority
- ES
- Spain
- Prior art keywords
- skin
- lipid composition
- advantageously
- polymeric material
- biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002632 lipids Chemical class 0.000 claims abstract description 159
- 239000000203 mixture Substances 0.000 claims abstract description 124
- 239000000463 material Substances 0.000 claims abstract description 88
- 238000000034 method Methods 0.000 claims abstract description 39
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 26
- 238000012876 topography Methods 0.000 claims abstract description 23
- 239000002537 cosmetic Substances 0.000 claims abstract description 19
- 235000021588 free fatty acids Nutrition 0.000 claims abstract description 15
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 14
- 239000004164 Wax ester Substances 0.000 claims abstract description 13
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 13
- 235000019386 wax ester Nutrition 0.000 claims abstract description 13
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims abstract description 12
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims abstract description 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940031439 squalene Drugs 0.000 claims abstract description 12
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000000694 effects Effects 0.000 claims abstract description 6
- 238000000576 coating method Methods 0.000 claims description 39
- 239000011248 coating agent Substances 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 21
- 239000002904 solvent Substances 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 13
- 238000000265 homogenisation Methods 0.000 claims description 9
- 238000001704 evaporation Methods 0.000 claims description 8
- 238000004528 spin coating Methods 0.000 claims description 4
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims 1
- 238000011109 contamination Methods 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 218
- 238000001727 in vivo Methods 0.000 description 41
- 229920001296 polysiloxane Polymers 0.000 description 29
- 210000002374 sebum Anatomy 0.000 description 26
- 238000005259 measurement Methods 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000004615 ingredient Substances 0.000 description 14
- 239000000839 emulsion Substances 0.000 description 11
- 239000003760 tallow Substances 0.000 description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 10
- 239000008406 cosmetic ingredient Substances 0.000 description 10
- 230000003993 interaction Effects 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 238000012856 packing Methods 0.000 description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 238000012512 characterization method Methods 0.000 description 6
- 239000003974 emollient agent Substances 0.000 description 6
- 230000008020 evaporation Effects 0.000 description 6
- 238000012623 in vivo measurement Methods 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- 210000000434 stratum corneum Anatomy 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 229930003427 Vitamin E Natural products 0.000 description 5
- 238000000151 deposition Methods 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 210000000245 forearm Anatomy 0.000 description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 5
- 238000002329 infrared spectrum Methods 0.000 description 5
- 238000000386 microscopy Methods 0.000 description 5
- 230000003278 mimic effect Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 235000019165 vitamin E Nutrition 0.000 description 5
- 229940046009 vitamin E Drugs 0.000 description 5
- 239000011709 vitamin E Substances 0.000 description 5
- BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- RJECHNNFRHZQKU-UHFFFAOYSA-N Oelsaeurecholesterylester Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCC=CCCCCCCCC)C2 RJECHNNFRHZQKU-UHFFFAOYSA-N 0.000 description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 229940106189 ceramide Drugs 0.000 description 4
- 150000001783 ceramides Chemical class 0.000 description 4
- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 description 4
- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000008271 cosmetic emulsion Substances 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 210000001061 forehead Anatomy 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 150000003408 sphingolipids Chemical class 0.000 description 4
- 230000035882 stress Effects 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 238000004566 IR spectroscopy Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000000736 corneocyte Anatomy 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- NZZFYRREKKOMAT-UHFFFAOYSA-N diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 238000001157 Fourier transform infrared spectrum Methods 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000001907 polarising light microscopy Methods 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 230000036555 skin type Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 230000037072 sun protection Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003190 viscoelastic substance Substances 0.000 description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 101150065749 Churc1 gene Proteins 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000001530 Raman microscopy Methods 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000010478 argan oil Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001840 cholesterol esters Chemical class 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 239000002649 leather substitute Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 238000013379 physicochemical characterization Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- SBIBMFFZSBJNJF-UHFFFAOYSA-N selenium;zinc Chemical compound [Se]=[Zn] SBIBMFFZSBJNJF-UHFFFAOYSA-N 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000048 toxicity data Toxicity 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D191/00—Coating compositions based on oils, fats or waxes; Coating compositions based on derivatives thereof
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Educational Administration (AREA)
- Medical Informatics (AREA)
- Algebra (AREA)
- Computational Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Health & Medical Sciences (AREA)
- Pure & Applied Mathematics (AREA)
- Business, Economics & Management (AREA)
- Medicinal Chemistry (AREA)
- Educational Technology (AREA)
- Theoretical Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Instructional Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306149 | 2018-08-30 | ||
| PCT/EP2019/073194 WO2020043873A1 (en) | 2018-08-30 | 2019-08-30 | Non-biological skin model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2927144T3 true ES2927144T3 (es) | 2022-11-02 |
Family
ID=63667842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19758994T Active ES2927144T3 (es) | 2018-08-30 | 2019-08-30 | Modelo de piel no biológica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12159552B2 (https=) |
| EP (1) | EP3844737B1 (https=) |
| JP (1) | JP7436055B2 (https=) |
| CN (1) | CN113574584B (https=) |
| AU (1) | AU2019332978A1 (https=) |
| CA (1) | CA3110540A1 (https=) |
| ES (1) | ES2927144T3 (https=) |
| WO (1) | WO2020043873A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7628285B2 (ja) * | 2021-03-31 | 2025-02-10 | 地方独立行政法人東京都立産業技術研究センター | 生体モデル用材料組成物及び生体モデル |
| CN113533649A (zh) * | 2021-07-14 | 2021-10-22 | 南开大学 | 一种适用于人体皮肤污染物暴露评估的模拟方法 |
| CN113740491B (zh) * | 2021-08-27 | 2025-03-25 | 无限极（中国）有限公司 | 一种用于感官评价的仿真皮肤及其制备方法 |
| EP4677357A1 (en) * | 2023-03-08 | 2026-01-14 | Unilever IP Holdings B.V. | Method for demonstrating the mode of action of a skin care product or component thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481001A (en) * | 1983-05-26 | 1984-11-06 | Collagen Corporation | Human skin model for intradermal injection demonstration or training |
| US4877454A (en) * | 1988-02-04 | 1989-10-31 | The Kendall Company | Model human skin |
| US5015431A (en) * | 1988-02-04 | 1991-05-14 | The Kendall Company | Process for making model skin |
| JP3829001B2 (ja) * | 1997-12-15 | 2006-10-04 | 株式会社資生堂 | 人工皮膚 |
| JP3589558B2 (ja) * | 1997-12-15 | 2004-11-17 | 株式会社資生堂 | 人工角層 |
| JP2001174392A (ja) | 1999-12-17 | 2001-06-29 | Shiseido Co Ltd | 皮脂移行性の評価法 |
| US7037112B2 (en) * | 2002-12-20 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Virtual arm for measurement of humidity, temperature, and water vapor transmission rate in materials |
| EP1937225B1 (en) * | 2005-08-12 | 2016-12-07 | The Procter and Gamble Company | Coated substrate with properties of keratinous tissue |
| US7549866B2 (en) * | 2005-12-15 | 2009-06-23 | Kimberly-Clark Worldwide, Inc. | Mannequin with more skin-like properties |
| US8417474B2 (en) * | 2006-02-10 | 2013-04-09 | The Procter & Gamble Company | Methods of use of substrate having properties of keratinous tissue |
| US10144204B2 (en) * | 2007-01-08 | 2018-12-04 | The Procter & Gamble Company | Substrate having properties of mammalian skin |
| JP2009062309A (ja) | 2007-09-06 | 2009-03-26 | Mandom Corp | 皮膚洗浄用化粧料 |
| JP2011022522A (ja) | 2009-07-20 | 2011-02-03 | Hitoo Okano | 皮膚モデル |
| US8765254B2 (en) * | 2010-04-05 | 2014-07-01 | Emd Millipore Corporation | Polymeric membranes with human skin-like permeability properties and uses thereof |
| GB2527513B (en) * | 2014-06-23 | 2021-01-20 | Secr Defence | Synthetic skin |
| CN105300848B (zh) * | 2015-11-23 | 2019-02-26 | 南京中医药大学 | 一种脂质体人工皮肤膜及其制备方法和在外用制剂中的应用 |
| US10755600B2 (en) * | 2016-08-30 | 2020-08-25 | St. Jude Medical, Cardiology Division, Inc. | Synthetic tissue phantom for medical evaluation |
| WO2019143498A1 (en) * | 2018-01-22 | 2019-07-25 | ClearIt, LLC | Methods and compositions for simulation of the dermal compartment |
-
2019
- 2019-08-30 EP EP19758994.8A patent/EP3844737B1/en active Active
- 2019-08-30 CN CN201980069269.6A patent/CN113574584B/zh active Active
- 2019-08-30 AU AU2019332978A patent/AU2019332978A1/en not_active Abandoned
- 2019-08-30 WO PCT/EP2019/073194 patent/WO2020043873A1/en not_active Ceased
- 2019-08-30 ES ES19758994T patent/ES2927144T3/es active Active
- 2019-08-30 JP JP2021536160A patent/JP7436055B2/ja active Active
- 2019-08-30 CA CA3110540A patent/CA3110540A1/en active Pending
- 2019-08-30 US US17/271,854 patent/US12159552B2/en active Active
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|---|---|
| CA3110540A1 (en) | 2020-03-05 |
| EP3844737A1 (en) | 2021-07-07 |
| WO2020043873A1 (en) | 2020-03-05 |
| US12159552B2 (en) | 2024-12-03 |
| JP7436055B2 (ja) | 2024-02-21 |
| CN113574584B (zh) | 2023-04-04 |
| US20210209967A1 (en) | 2021-07-08 |
| EP3844737B1 (en) | 2022-07-27 |
| JP2021535448A (ja) | 2021-12-16 |
| CN113574584A (zh) | 2021-10-29 |
| AU2019332978A1 (en) | 2021-03-11 |
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