ES291841A1 - Procedimiento para la producciën de derivados de cefalosporina c. - Google Patents
Procedimiento para la producciën de derivados de cefalosporina c.Info
- Publication number
- ES291841A1 ES291841A1 ES0291841A ES291841A ES291841A1 ES 291841 A1 ES291841 A1 ES 291841A1 ES 0291841 A ES0291841 A ES 0291841A ES 291841 A ES291841 A ES 291841A ES 291841 A1 ES291841 A1 ES 291841A1
- Authority
- ES
- Spain
- Prior art keywords
- cephalosporanic acid
- hydrogen
- acid
- dimethyldithiocarbamate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- MZGNSEAPZQGJRB-UHFFFAOYSA-N dimethyldithiocarbamic acid Chemical compound CN(C)C(S)=S MZGNSEAPZQGJRB-UHFFFAOYSA-N 0.000 abstract 10
- 150000003839 salts Chemical class 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- -1 n - butylthioacetamido Chemical group 0.000 abstract 5
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 abstract 4
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000003073 divalent carboacyl group Chemical group 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 abstract 1
- 239000012990 dithiocarbamate Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- APGXDGZXGZROMN-UHFFFAOYSA-N n-piperidin-1-ium-1-ylcarbamodithioate Chemical compound SC(=S)NN1CCCCC1 APGXDGZXGZROMN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 229940056360 penicillin g Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB36237/62A GB1059562A (en) | 1962-09-24 | 1962-09-24 | Derivatives of cephalosporin c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES291841A1 true ES291841A1 (es) | 1964-02-16 |
Family
ID=10386243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0291841A Expired ES291841A1 (es) | 1962-09-24 | 1963-09-20 | Procedimiento para la producciën de derivados de cefalosporina c. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3258461A (d) |
| AT (1) | AT253119B (d) |
| BE (1) | BE637547A (d) |
| CA (1) | CA835385A (d) |
| CH (1) | CH442309A (d) |
| DE (1) | DE1445823A1 (d) |
| ES (1) | ES291841A1 (d) |
| FR (2) | FR2952M (d) |
| GB (1) | GB1059562A (d) |
| SE (1) | SE334360B (d) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208515A (en) * | 1973-02-23 | 1980-06-17 | Eli Lilly And Company | 3-Halo cephalosporins |
| US4260745A (en) * | 1979-10-12 | 1981-04-07 | Eli Lilly And Company | 3-Halo cephalosporins |
| US4281116A (en) * | 1979-10-12 | 1981-07-28 | Eli Lilly And Company | 3-Halo cephalosporins |
| US4252950A (en) * | 1979-10-12 | 1981-02-24 | Eli Lilly And Company | 3-Halo cephalosporins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2872375A (en) * | 1955-03-21 | 1959-02-03 | Lepetit Spa | Stabilized penicillin salts |
| US2966442A (en) * | 1956-09-20 | 1960-12-27 | American Home Prod | Antibiotic compositions |
| US3167550A (en) * | 1962-11-13 | 1965-01-26 | Smith Kline French Lab | Derivatives of 7-aminocephalosporanic acid |
| US3129224A (en) * | 1962-11-23 | 1964-04-14 | Smith Kline French Lab | Antimicrobial 3-methyl-7-aminodecepha-losporanic acid derivatives |
-
0
- CA CA835385A patent/CA835385A/en not_active Expired
-
1962
- 1962-09-24 GB GB36237/62A patent/GB1059562A/en not_active Expired
-
1963
- 1963-09-16 US US309331A patent/US3258461A/en not_active Expired - Lifetime
- 1963-09-18 BE BE637547A patent/BE637547A/fr unknown
- 1963-09-20 ES ES0291841A patent/ES291841A1/es not_active Expired
- 1963-09-20 DE DE19631445823 patent/DE1445823A1/de active Pending
- 1963-09-20 CH CH1160263A patent/CH442309A/de unknown
- 1963-09-23 SE SE10350/63A patent/SE334360B/xx unknown
- 1963-09-23 AT AT763463A patent/AT253119B/de active
- 1963-09-24 FR FR948467A patent/FR2952M/fr not_active Expired
- 1963-09-24 FR FR948468A patent/FR1476508A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1445823A1 (de) | 1969-10-09 |
| AT253119B (de) | 1967-03-28 |
| SE334360B (d) | 1971-04-26 |
| US3258461A (en) | 1966-06-28 |
| CA835385A (en) | 1970-02-24 |
| GB1059562A (en) | 1967-02-22 |
| BE637547A (fr) | 1964-03-18 |
| FR2952M (d) | 1964-12-24 |
| CH442309A (de) | 1967-08-31 |
| FR1476508A (fr) | 1967-04-14 |
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