ES2915901T3 - Compuestos tetracíclicos condensados, composiciones y usos de los mismos - Google Patents
Compuestos tetracíclicos condensados, composiciones y usos de los mismos Download PDFInfo
- Publication number
- ES2915901T3 ES2915901T3 ES17736213T ES17736213T ES2915901T3 ES 2915901 T3 ES2915901 T3 ES 2915901T3 ES 17736213 T ES17736213 T ES 17736213T ES 17736213 T ES17736213 T ES 17736213T ES 2915901 T3 ES2915901 T3 ES 2915901T3
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolo
- mmol
- diazepin
- bromo
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662274640P | 2016-01-04 | 2016-01-04 | |
| PCT/US2017/012092 WO2017120164A1 (en) | 2016-01-04 | 2017-01-04 | Fused quadracyclic compounds, compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2915901T3 true ES2915901T3 (es) | 2022-06-27 |
Family
ID=59226993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17736213T Active ES2915901T3 (es) | 2016-01-04 | 2017-01-04 | Compuestos tetracíclicos condensados, composiciones y usos de los mismos |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10059718B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3400228B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP7068185B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN108779123B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2017205320B2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2915901T3 (cg-RX-API-DMAC10.html) |
| TW (1) | TWI730027B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2017120164A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10059718B2 (en) | 2016-01-04 | 2018-08-28 | Tabomedex Biosciences, LLC | Fused quadracyclic compounds, compositions and uses thereof |
| CN107879989B (zh) * | 2017-11-29 | 2020-01-03 | 重庆市中药研究院 | 具有生物活性的3,4,5-取代苯并二氮卓2-酮类药物分子及其制备方法 |
| BR112023013722A2 (pt) * | 2021-01-11 | 2024-01-30 | Tabomedex Biosciences Inc | Compostos quadracílicos fundidos, composições e usos dos mesmos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521534A (en) | 1983-12-19 | 1985-06-04 | Ayerst, Mckenna & Harrison, Ltd. | Imidazo[2,1-a]pyrrolo[2,1-c][1,4]benzodiazepine derivatives, methods of preparation and use |
| US4596799A (en) | 1985-01-29 | 1986-06-24 | Ciba-Geigy Corporation | 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines |
| TWI239333B (en) | 2000-11-16 | 2005-09-11 | Hoffmann La Roche | Benzodiazepine derivatives as GABA A receptor modulators |
| BR0317430A (pt) | 2002-12-20 | 2005-10-25 | Pharmacia Corp | Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno |
| US10138256B2 (en) | 2013-03-15 | 2018-11-27 | Celgene Car Llc | MK2 inhibitors and uses thereof |
| US20160066387A1 (en) * | 2013-03-22 | 2016-03-03 | Lifi Labs Inc | Color selection |
| US10059718B2 (en) | 2016-01-04 | 2018-08-28 | Tabomedex Biosciences, LLC | Fused quadracyclic compounds, compositions and uses thereof |
-
2017
- 2017-01-03 US US15/397,212 patent/US10059718B2/en active Active
- 2017-01-04 JP JP2018553855A patent/JP7068185B2/ja active Active
- 2017-01-04 CN CN201780005620.6A patent/CN108779123B/zh active Active
- 2017-01-04 AU AU2017205320A patent/AU2017205320B2/en active Active
- 2017-01-04 EP EP17736213.4A patent/EP3400228B1/en active Active
- 2017-01-04 WO PCT/US2017/012092 patent/WO2017120164A1/en not_active Ceased
- 2017-01-04 TW TW106100215A patent/TWI730027B/zh active
- 2017-01-04 ES ES17736213T patent/ES2915901T3/es active Active
-
2018
- 2018-07-19 US US16/039,877 patent/US10562909B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN108779123A (zh) | 2018-11-09 |
| TWI730027B (zh) | 2021-06-11 |
| US10059718B2 (en) | 2018-08-28 |
| AU2017205320B2 (en) | 2021-06-24 |
| EP3400228A4 (en) | 2019-08-14 |
| US20170190713A1 (en) | 2017-07-06 |
| EP3400228A1 (en) | 2018-11-14 |
| TW201726681A (zh) | 2017-08-01 |
| JP7068185B2 (ja) | 2022-05-16 |
| US10562909B2 (en) | 2020-02-18 |
| WO2017120164A1 (en) | 2017-07-13 |
| JP2019501971A (ja) | 2019-01-24 |
| CA3010213A1 (en) | 2017-07-13 |
| EP3400228B1 (en) | 2022-04-13 |
| CN108779123B (zh) | 2025-08-19 |
| AU2017205320A1 (en) | 2018-07-05 |
| US20180319809A1 (en) | 2018-11-08 |
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