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Merck KGaA
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E Merck AG
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Publication of ES289157A1publicationCriticalpatent/ES289157A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Process for preparing substituted amines of the formula I ** (See formula) ** where R1 = H, methyl or ethyl R2 = H, fenilo o X R3 = phenoxy or R2 R4 = h or alkyl with 1 to 4 carbon atoms or hydroxyalkyl with 1 to 4 carbon atoms X = a phenyl radical substituted once or twice by tertiary alkyl with 4 to 6 carbon atoms and optionally once or twice by alkyl with 1 to 4 carbon atoms and optionally by an OH group Y = straight or branched alkylene with 1 to 3 carbon atoms m = 0 o 1 n = 1-3, in which case the group (CH2) -CHR1 has a total of 4 carbon atoms at most, as well as its acid addition salts, characterized in that: a) is introduced, by reacting substitution or addition currents, in an amine of formula II (see formula) the radical ** (See formula) ** or in an amine of formula III (see formula) the radical ** (See formula) ** or in an amine of formula IV (see formula) the radical R4 where R1 to R4, X, Y, m and n have the meaning stated above, O well b) a compound with the basic structure of the formula I is treated with reducing agents, which contains radicals which can be removed by the hydrogenolytic route or a double bond C = N or one or more non-aromatic C = C double bonds or one or more carbonyl groups, O well c) in a compound with the basic structure of formula I, which contains a hydroxy or functionally modified amino group, the hydroxy group and/or the amino group is released or an amino group is transformed instead of a group hydroxy, by diazoation and boiling in a hydroxy group, and eventually d) a tertiary amine of the formula I is converted, by treatment with an acid, into a physiologically compatible acid addition salt, or a free base of the formula I is released from its acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0289157A1962-06-191963-06-18Procedure for preparing substitute amines (Machine-translation by Google Translate, not legally binding)
ExpiredES289157A1
(en)
Procedure for the preparation of N-substituted piperidine derivatives and their use as stabilizers. (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of combinations type acid 3, 4, 5-trial-coxibenzoil-aminoalcano-carboxilico and their salts. (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of l-alpha-hydrazino-beta-phenylpropionic acid compounds. (Machine-translation by Google Translate, not legally binding)