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Merck KGaA
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E Merck AG
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Publication of ES288504A1publicationCriticalpatent/ES288504A1/en
Process for preparing primary amines of the formula I ** (See formula) ** where R = H, methyl or ethyl n = 0 to 3, in which case the group (CH2) n-CHR- has at most 4 carbon atoms R1 = tertiary alkyl group with 4 to 6 carbon atoms and wherein the phenyl nucleus is further substituted by a hydroxyl group and/or a tertiary alkyl group with 4 to 6 carbon atoms and/or once or twice by alkyl with 1 to 4 carbon atoms, as well as its acid addition salts, characterized in that: a) a compound of the formula II is treated with reducing agents ** (See formula) ** where R1 and n have the meaning stated above and X means either a radical transformable by reduction in a CHR-NH group, or, if in the starting compound of formula II there are, instead of hydrogen atoms, radicals removable by hydrogenolytic route, or one or more groups carbonyl or one or more non-aromatic double bonds, a CHR-NH2 group, O well b) it is treated with ammonia, or with ammonia-transferring agents, a compound of formula I which, in place of the amine group, contains a radical substituted by an amine group, O well c) in a compound with the basic structure of formula I containing in the phenyl nucleus a functionally modified hydroxy group and/or whose amine group is in functionally modified form, the hydroxy group and/or the amine group is released O well d) a primary amine of the formula I is converted, by treatment with a physiologically compatible acid, into an acid addition salt, or is released from its acid addition salt, a base of the formula I . (Machine-translation by Google Translate, not legally binding)
ES0288504A1962-05-301963-05-29Procedure for preparing primary amines (Machine-translation by Google Translate, not legally binding)
ExpiredES288504A1
(en)
Procedure for the preparation of N-substituted piperidine derivatives and their use as stabilizers. (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of l-alpha-hydrazino-beta-phenylpropionic acid compounds. (Machine-translation by Google Translate, not legally binding)