ES287190A1 - A procedure for the preparation of steroids (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of steroids (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES287190A1
ES287190A1 ES287190A ES287190A ES287190A1 ES 287190 A1 ES287190 A1 ES 287190A1 ES 287190 A ES287190 A ES 287190A ES 287190 A ES287190 A ES 287190A ES 287190 A1 ES287190 A1 ES 287190A1
Authority
ES
Spain
Prior art keywords
17beta
oac
delta2
seco
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES287190A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES287190A1 publication Critical patent/ES287190A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

A steroid preparation process of the general formula I: ** (See formula) ** wherein R represents hydrogen or the acyl radical of a lower organic carboxylic acid, characterized in that it is converted by means of a functional derivative of acetic acid and in the presence of an acid catalyst, 3-chloro 5-oxo-17beta-OAc 4 , 5-seco delta2,9-estradiene in 3-chloro-5-acetoxy 17beta-OAc 4,5-seco delta2,5 (10) 9 (11) -estratriene, this is subjected to the action of a brominating agent in the presence from a tertiary base, the dehromhydration of the 3-chloro-5-oxo-17beta-OAc-11-bromo-4,5-seco delta2,9-estradiene is carried out, which leads to the 3-chloro-5-oxo-17beta-OAc 4,5- dry delta2,9,11-corresponding ester, which is subjected to acid hydrolysis, is cyclized 3,5-dioxo-17beta-OAc 4,5-seco delta9,11-estradiene formed in alkaline medium, 3-oxo is saponified 17beta -OAc delta4,9,11-estratriene obtained by means of (Machine-translation by Google Translate, not legally binding)
ES287190A 1962-04-20 1963-04-19 A procedure for the preparation of steroids (Machine-translation by Google Translate, not legally binding) Expired ES287190A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR895239A FR1380414A (en) 1962-04-20 1962-04-20 Novel estratriene steroids and method of preparation

Publications (1)

Publication Number Publication Date
ES287190A1 true ES287190A1 (en) 1963-06-01

Family

ID=8777413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES287190A Expired ES287190A1 (en) 1962-04-20 1963-04-19 A procedure for the preparation of steroids (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
AT (1) AT253694B (en)
BR (1) BR6348531D0 (en)
CH (1) CH414608A (en)
DK (1) DK104232C (en)
ES (1) ES287190A1 (en)
FR (2) FR1380414A (en)
GB (3) GB1035683A (en)
SE (1) SE308310B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183555B1 (en) * 1972-05-10 1975-06-20 Roussel Uclaf
FR2388560A1 (en) * 1977-04-27 1978-11-24 Roussel Uclaf NEW ZOOTECHNICAL COMPOSITIONS CONTAINING ON THE ONE HAND ZERANOL AND ON THE OTHER HAND A STEROID 4,9,11 TRIENIQUE
JP3014784B2 (en) * 1991-02-13 2000-02-28 日本ユクラフ株式会社 Drugs for preventing stress in fish
FR2674436B1 (en) * 1991-03-28 1995-01-20 Roussel Uclaf NEW USE OF 4,9,11-TRIENIC STEROUIDES IN COMPOSITIONS FOR ADMINISTRATION IN TURKEY.
EP4001289B1 (en) * 2020-11-19 2023-05-03 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of trenbolone and/or trenbolone acetate
EP4001288A1 (en) * 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution and a irregular hexagon plates crystal habit
EP4000688A1 (en) * 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution

Also Published As

Publication number Publication date
GB1035685A (en) 1966-07-13
GB1035684A (en) 1966-07-13
FR1958M (en) 1963-08-05
SE308310B (en) 1969-02-10
AT253694B (en) 1967-04-25
GB1035683A (en) 1966-07-13
DK104232C (en) 1966-04-25
FR1380414A (en) 1964-12-04
CH414608A (en) 1966-06-15
BR6348531D0 (en) 1973-07-03

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