ES2871783T3 - Compuestos para el tratamiento de trastornos del metabolismo de las lipoproteínas - Google Patents
Compuestos para el tratamiento de trastornos del metabolismo de las lipoproteínas Download PDFInfo
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- ES2871783T3 ES2871783T3 ES17776978T ES17776978T ES2871783T3 ES 2871783 T3 ES2871783 T3 ES 2871783T3 ES 17776978 T ES17776978 T ES 17776978T ES 17776978 T ES17776978 T ES 17776978T ES 2871783 T3 ES2871783 T3 ES 2871783T3
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (2)
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| DKPA201670733 | 2016-09-20 | ||
| PCT/EP2017/073747 WO2018054959A1 (en) | 2016-09-20 | 2017-09-20 | Compounds for treatment of lipoprotein metabolism disorders |
Publications (1)
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| ES2871783T3 true ES2871783T3 (es) | 2021-11-02 |
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| EP3973958A3 (en) * | 2015-03-20 | 2022-06-22 | Aarhus Universitet | Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders |
| KR102137147B1 (ko) * | 2018-07-16 | 2020-07-24 | 경희대학교 산학협력단 | 벤질 알파-d-갈락토피라노사이드 또는 (-)-세코이소라리시레시놀-9'-o-베타-d-글루코피라노사이드를 포함하는 당뇨병 예방 또는 치료용 조성물 |
| SE543275C2 (en) * | 2019-03-07 | 2020-11-10 | Tx Medic Ab | Treatment efficiency evaluation |
| WO2021122793A1 (en) * | 2019-12-17 | 2021-06-24 | Norinvent Ab | Sulfated disaccharides as enhancers of transmucosal drug uptake |
| KR20230057410A (ko) | 2020-08-25 | 2023-04-28 | 리제너론 파마슈티칼스 인코포레이티드 | Pcsk9 및 ldlr 조절인자를 사용한 패혈증 치료 |
| CN116854752A (zh) * | 2022-03-28 | 2023-10-10 | 南开大学 | 肝素三糖结构化合物及其制药应用 |
| CN116270507A (zh) * | 2023-03-02 | 2023-06-23 | 青岛海洋生物医药研究院股份有限公司 | 一种含脂蛋白脂酶刺激剂的舌下含片及其制备方法和应用 |
| CN119708089A (zh) * | 2023-09-27 | 2025-03-28 | 南开大学 | 一种磺酸化三糖及其制备方法和治疗应用 |
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| US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
| WO1993007167A1 (en) * | 1991-10-04 | 1993-04-15 | The Procter & Gamble Company | Cholesterol lowering compounds and process for making them |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| US5366473A (en) | 1992-08-18 | 1994-11-22 | Ultrasonic Sensing And Monitoring Systems, Inc. | Method and apparatus for applying vascular grafts |
| GB9221657D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant bispecific antibodies |
| EP0628078B1 (en) | 1992-12-11 | 1999-12-08 | The Dow Chemical Company | Multivalent single chain antibodies |
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| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US8828952B2 (en) | 2007-10-16 | 2014-09-09 | Progen Pharmaceuticals Limited | Sulfated oligosaccharide derivatives |
| TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| US8889840B2 (en) * | 2009-10-29 | 2014-11-18 | Industry-Academic Cooperation Foundation, Yonsei University | Vascular leakage inhibitor |
| JP6170940B2 (ja) | 2011-12-20 | 2017-07-26 | アダエラータ、リミテッド パートナーシップＡｄａｅｒａｔａ， Ｌｉｍｉｔｅｄ Ｐａｒｔｎｅｒｓｈｉｐ | Ｐｃｓｋ９の阻害剤としての単一ドメイン抗体 |
| WO2013148284A1 (en) | 2012-03-29 | 2013-10-03 | Genentech, Inc. | Antibodies that bind to a pcsk9 cleavage site and methods of use |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| JP2015517579A (ja) | 2012-05-25 | 2015-06-22 | カタバシス ファーマシューティカルズ，インコーポレイテッド | プロタンパク質転換酵素スブチリシン／ケキシン９型（ｐｃｓｋ９）を低下させる方法 |
| US20150190369A1 (en) * | 2012-07-03 | 2015-07-09 | Majambu Mbikay | Quercetin-3-glucoside and uses thereof |
| CN110090304A (zh) | 2012-08-02 | 2019-08-06 | 康德生物医疗技术公司 | 用于治疗动脉粥样硬化的方法 |
| WO2014150983A2 (en) | 2013-03-15 | 2014-09-25 | Amgen Inc. | Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 |
| WO2016046684A1 (en) | 2014-09-23 | 2016-03-31 | Pfizer Inc. | Treatment with anti-pcsk9 antibodies |
| EP3973958A3 (en) * | 2015-03-20 | 2022-06-22 | Aarhus Universitet | Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders |
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| EP3515455B1 (en) | 2021-04-14 |
| CA3035875A1 (en) | 2018-03-29 |
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| US20190275074A1 (en) | 2019-09-12 |
| JP7046381B2 (ja) | 2022-04-04 |
| US20220054530A1 (en) | 2022-02-24 |
| US11173177B2 (en) | 2021-11-16 |
| AU2017329799A1 (en) | 2019-04-11 |
| EP3515455A1 (en) | 2019-07-31 |
| JP2019529402A (ja) | 2019-10-17 |
| WO2018054959A1 (en) | 2018-03-29 |
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