ES2831853T3 - Compuestos para tratar los trastornos sensibles a la regulación serotoninérgica controlada por los receptores 5-HT1A - Google Patents

Compuestos para tratar los trastornos sensibles a la regulación serotoninérgica controlada por los receptores 5-HT1A Download PDF

Info

Publication number
ES2831853T3
ES2831853T3 ES17734043T ES17734043T ES2831853T3 ES 2831853 T3 ES2831853 T3 ES 2831853T3 ES 17734043 T ES17734043 T ES 17734043T ES 17734043 T ES17734043 T ES 17734043T ES 2831853 T3 ES2831853 T3 ES 2831853T3
Authority
ES
Spain
Prior art keywords
compound
iib
nmr
mhz
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17734043T
Other languages
English (en)
Spanish (es)
Inventor
Joanna Sniecikowska
Adam Bucki
Adrian Newman-Tancredi
Mark Andrew Varney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JAGELLONE, University of
Neurolixis
Universite Jagellone
Original Assignee
JAGELLONE, University of
Neurolixis
Universite Jagellone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JAGELLONE, University of, Neurolixis, Universite Jagellone filed Critical JAGELLONE, University of
Application granted granted Critical
Publication of ES2831853T3 publication Critical patent/ES2831853T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38Halogen atoms or nitro radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
ES17734043T 2016-06-24 2017-06-23 Compuestos para tratar los trastornos sensibles a la regulación serotoninérgica controlada por los receptores 5-HT1A Active ES2831853T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305769.8A EP3260452A1 (en) 2016-06-24 2016-06-24 Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-ht1a receptors
PCT/EP2017/065585 WO2017220799A1 (en) 2016-06-24 2017-06-23 Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-ht1a receptors

Publications (1)

Publication Number Publication Date
ES2831853T3 true ES2831853T3 (es) 2021-06-09

Family

ID=56404042

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17734043T Active ES2831853T3 (es) 2016-06-24 2017-06-23 Compuestos para tratar los trastornos sensibles a la regulación serotoninérgica controlada por los receptores 5-HT1A

Country Status (9)

Country Link
US (1) US10562853B2 (enExample)
EP (2) EP3260452A1 (enExample)
JP (1) JP6935873B2 (enExample)
CN (1) CN109563073B (enExample)
AU (1) AU2017281742B2 (enExample)
CA (1) CA3028036A1 (enExample)
DK (1) DK3475268T3 (enExample)
ES (1) ES2831853T3 (enExample)
WO (1) WO2017220799A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119874616B (zh) * 2025-03-28 2025-05-30 四川美域高生物医药科技有限公司 一种有机中间体及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702211B1 (fr) * 1993-03-04 1995-06-02 Pf Medicament Nouveaux dérivés de la phénoxy-2 éthylamine, leur préparation et leur application en thérapeutique.
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments
FR2784378B1 (fr) * 1998-10-09 2000-12-29 Pf Medicament Nouveaux derives d'aryl-(4-fluoro-4-[(2-pyridin-2-yl- ethylamino)-methyl]-piperidin-1-yl)-methanone, leur procede de preparation et leur utilisation a titre de medicaments
EP2058306A1 (en) * 2007-11-08 2009-05-13 Schwarz Pharma Ag Heteroaryl-substituted 2-pyridinyl-methylamine derivatives
PL395470A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Sulfonamidowe pochodne amin alicyklicznych do leczenia chorób osrodkowego ukladu nerwowego

Also Published As

Publication number Publication date
CN109563073B (zh) 2021-12-07
EP3475268B1 (en) 2020-08-19
JP6935873B2 (ja) 2021-09-15
CA3028036A1 (en) 2017-12-28
EP3260452A1 (en) 2017-12-27
EP3475268A1 (en) 2019-05-01
JP2019519615A (ja) 2019-07-11
CN109563073A (zh) 2019-04-02
WO2017220799A1 (en) 2017-12-28
DK3475268T3 (da) 2020-10-26
US20190194132A1 (en) 2019-06-27
AU2017281742A1 (en) 2019-01-03
AU2017281742B2 (en) 2021-01-07
EP3475268B9 (en) 2021-04-21
US10562853B2 (en) 2020-02-18

Similar Documents

Publication Publication Date Title
ES2855135T3 (es) Amidas heterocíclicas como inhibidores de quinasa
ES2290538T3 (es) Nuevas imidazopiridinas y su uso.
KR102072850B1 (ko) 브로모도메인 억제제로서의 벤즈이미다졸 유도체
JP2022544714A (ja) 甲状腺ホルモン受容体ベータアゴニスト化合物
ES2585244T3 (es) Composiciones y métodos para modular una cinasa
BR112021000332A2 (pt) Compostos químicos
US9567304B2 (en) Quinazolinedione derivative
BR112015017963A2 (pt) composto de fenil amino pirimidina deuterado, método para preparar a composição farmacêutica, composição farmacêutica e uso do composto
CN117440955A (zh) 具有食欲素-2受体激动剂活性的取代的酰胺大环化合物
TR201819140T4 (tr) Spirosiklik amid türevleri.
ES2984158T3 (es) Inhibidores y moduladores de WDR5
KR20200127223A (ko) 옥사지노-퀴나졸린 및 옥사지노-퀴놀린형 화합물, 이의 제조방법 및 용도
ES2831853T3 (es) Compuestos para tratar los trastornos sensibles a la regulación serotoninérgica controlada por los receptores 5-HT1A
JP2020193209A (ja) チアゾール誘導体の製造方法
EP3085695A1 (en) Substituted triazinone compound and t-type calcium channel inhibitor
ES2983860T3 (es) Antagonistas del receptor muscarínico 4 y métodos de uso
HK40007735A (en) Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-ht1a receptors
HK40007735B (en) Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-ht1a receptors
JP4328873B2 (ja) 放射線増感剤
EA050101B1 (ru) СОЕДИНЕНИЯ, ТАРГЕТИРУЮЩИЕ МУТАНТ р53
NZ793902A (en) Substituted 2-azabicycles and their use as orexin receptor modulators
ES2359857T3 (es) Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2-il)piridin-3-amina y compuestos relacionados como inhibidores del receptor de p2y1 para el tratamiento de trastornos tromboembólicos.
KR20240089380A (ko) 마보릭사포의 합성 및 그 중간체
WO2010094721A1 (en) Piperidin-pyrimidine derivatives as antagonists of histamine h4 receptor