ES2827024T3 - Combinación de inhibidores de Raf y de taxanos - Google Patents
Combinación de inhibidores de Raf y de taxanos Download PDFInfo
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- ES2827024T3 ES2827024T3 ES15874331T ES15874331T ES2827024T3 ES 2827024 T3 ES2827024 T3 ES 2827024T3 ES 15874331 T ES15874331 T ES 15874331T ES 15874331 T ES15874331 T ES 15874331T ES 2827024 T3 ES2827024 T3 ES 2827024T3
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462096020P | 2014-12-23 | 2014-12-23 | |
| US201562242629P | 2015-10-16 | 2015-10-16 | |
| PCT/US2015/067462 WO2016106359A1 (en) | 2014-12-23 | 2015-12-22 | Combination of raf inhibitors and taxanes |
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| ES2827024T3 true ES2827024T3 (es) | 2021-05-19 |
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| ES15874331T Active ES2827024T3 (es) | 2014-12-23 | 2015-12-22 | Combinación de inhibidores de Raf y de taxanos |
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| EP (1) | EP3236966B1 (enExample) |
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| ES (1) | ES2827024T3 (enExample) |
| WO (1) | WO2016106359A1 (enExample) |
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| EP4065122A4 (en) * | 2019-11-27 | 2023-12-27 | Day One Biopharmaceuticals, Inc. | Solid dispersion of pan-raf kinase inhibitor |
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| CL2008001933A1 (es) * | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| CA2694646C (en) * | 2007-07-30 | 2017-09-05 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| JO3101B1 (ar) * | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
| KR20110100241A (ko) * | 2008-12-05 | 2011-09-09 | 아르퀼 인코포레이티드 | Ｒａｆ 억제제 및 이들의 용도 |
| RU2553379C2 (ru) * | 2009-08-24 | 2015-06-10 | Дженентек, Инк. | ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ K-ras И УРОВНЕЙ ЭКСПРЕССИИ RTK |
| WO2013144923A1 (en) * | 2012-03-30 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma |
| CA2904338C (en) * | 2013-03-05 | 2022-07-05 | University Of Tennessee Research Foundation | Use of imidazole derivatives in combination with a braf inhibitor or mek inhibitor in the treatment of cancer |
| UY36046A (es) * | 2014-03-26 | 2015-10-30 | Millennium Pharm Inc | Formulaciones farmacéuticas, procesos para la preparación y métodos de uso |
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2015
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- 2015-12-22 CA CA2972189A patent/CA2972189A1/en not_active Abandoned
- 2015-12-22 US US15/539,185 patent/US20190117652A1/en not_active Abandoned
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2020
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| CA2972189A1 (en) | 2016-06-30 |
| JP2020114857A (ja) | 2020-07-30 |
| EP3236966A4 (en) | 2018-10-03 |
| JP2018502087A (ja) | 2018-01-25 |
| EP3236966B1 (en) | 2020-08-12 |
| US20200316067A1 (en) | 2020-10-08 |
| WO2016106359A1 (en) | 2016-06-30 |
| EP3236966A1 (en) | 2017-11-01 |
| CN107405348A (zh) | 2017-11-28 |
| US20190117652A1 (en) | 2019-04-25 |
| CN107405348B (zh) | 2021-06-11 |
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