ES2816060T3 - Aza-aril 1H-pirazol-1-il-bencenosulfonamidas como antagonistas de CCR(9) - Google Patents

Aza-aril 1H-pirazol-1-il-bencenosulfonamidas como antagonistas de CCR(9) Download PDF

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Publication number
ES2816060T3
ES2816060T3 ES17184205T ES17184205T ES2816060T3 ES 2816060 T3 ES2816060 T3 ES 2816060T3 ES 17184205 T ES17184205 T ES 17184205T ES 17184205 T ES17184205 T ES 17184205T ES 2816060 T3 ES2816060 T3 ES 2816060T3
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Xi Chen
Junfa Fan
Pingchen Fan
Antoni Krasinski
Lianfa Li
Rebecca Lui
Jeffrey Mcmahon
Jay Powers
Yibin Zeng
Penglie Zhang
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Chemocentryx Inc
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ES17184205T 2012-02-29 2013-02-28 Aza-aril 1H-pirazol-1-il-bencenosulfonamidas como antagonistas de CCR(9) Active ES2816060T3 (es)

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US201261604998P 2012-02-29 2012-02-29

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ES13708633.6T Active ES2645617T3 (es) 2012-02-29 2013-02-28 Pirazol-1-il benceno sulfonamidas como antagonistas del CCR9
ES17184205T Active ES2816060T3 (es) 2012-02-29 2013-02-28 Aza-aril 1H-pirazol-1-il-bencenosulfonamidas como antagonistas de CCR(9)

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EP (3) EP3738958A1 (da)
JP (3) JP6249966B2 (da)
KR (1) KR102083693B1 (da)
CN (2) CN107266425B (da)
AU (3) AU2013225938B2 (da)
BR (1) BR112014021148B1 (da)
CA (1) CA2865714C (da)
DK (2) DK3263564T3 (da)
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HK (3) HK1206012A1 (da)
MX (1) MX2014010340A (da)
PL (2) PL3263564T3 (da)
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US9100454B2 (en) 2006-04-07 2015-08-04 Groupon, Inc. Method and system for enabling the creation and maintenance of proximity-related user groups
US10827315B2 (en) * 2006-04-07 2020-11-03 Groupon, Inc. Facilitating user interactions based on proximity
RU2627268C2 (ru) 2012-02-29 2017-08-04 Хемоцентрикс, Инк. Аза-арил-1Н-пиразол-1-ил-сульфонамиды
UY35165A (es) 2012-12-04 2014-06-30 Takeda Pharmaceutical Método profiláctico o terapéutico para el síndrome de sjogren
GB201308978D0 (en) 2013-05-17 2013-07-03 Imp Innovations Ltd Method for producing polymers and block copolymers
JP6563947B2 (ja) * 2013-12-02 2019-08-21 ケモセントリックス，インコーポレイティド Ｃｃｒ６化合物
AU2014372638A1 (en) * 2013-12-23 2016-06-16 Norgine B.V. Compounds useful as CCR9 modulators
AU2015328396B2 (en) * 2014-10-06 2021-02-04 Chemocentryx, Inc. Combination therapy of inhibitors of C-C chemokine receptor type 9 (CCR9) and anti-alha4beta7 integrin blocking antibodies
GB201515350D0 (en) 2015-08-28 2015-10-14 Econic Technologies Ltd Method for preparing polyols
AU2017209023B2 (en) 2016-01-20 2021-06-17 Chemocentryx, Inc. 2-oxindole compounds
KR20230047210A (ko) * 2016-06-13 2023-04-06 케모센트릭스, 인크. 췌장 암을 치료하는 방법
EP3634417B1 (en) * 2017-05-17 2023-07-12 Arcus Biosciences, Inc. Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders
AU2019312296A1 (en) * 2018-07-27 2021-03-18 Arcus Biosciences, Inc. Pyridone A2R antagonists
US20200319677A1 (en) * 2018-10-24 2020-10-08 Clay Canning Screen protector with engraved image
US11872217B2 (en) 2019-07-10 2024-01-16 Chemocentryx, Inc. Indanes as PD-L1 inhibitors
US10792360B1 (en) 2019-11-21 2020-10-06 Chemocentryx, Inc. Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies
TW202203916A (zh) * 2020-03-31 2022-02-01 美商卡默森屈有限公司 使用ｃｃｒ９抑制劑及抗ｉｌ—２３阻斷抗體治療發炎性腸道疾病的組成物及方法
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Ｐｐａｒｇ反向激動劑及其用途
KR102584607B1 (ko) 2023-01-19 2023-10-04 아주대학교산학협력단 1h-피라졸-3-아마이드계 화합물 유도체를 포함하는 염증성 피부질환 예방 또는 치료용 조성물

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US6159686A (en) 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US5514555A (en) 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6326144B1 (en) 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
EP1507756B1 (en) * 2002-05-24 2015-07-22 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
EP1798223B2 (en) * 2002-11-18 2014-07-30 ChemoCentryx, Inc. Aryl sulfonamides
TW200510311A (en) * 2002-12-23 2005-03-16 Millennium Pharm Inc CCr8 inhibitors
SE0301653D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
US7932252B2 (en) * 2004-05-12 2011-04-26 Chemocentryx, Inc. Aryl sulfonamides
SE0402635D0 (sv) 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
WO2008008374A2 (en) * 2006-07-14 2008-01-17 Chemocentryx, Inc. Ccr2 inhibitors and methods of use thereof
ATE498615T1 (de) * 2006-07-14 2011-03-15 Chemocentryx Inc Triazolylphenylbenzensulfonamide
EA200901042A1 (ru) 2007-02-06 2010-02-26 Новартис Аг Производные 1-бензенсульфонил-1h-индола в качестве ингибиторов активности ccr9
US7776877B2 (en) * 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
RU2627268C2 (ru) 2012-02-29 2017-08-04 Хемоцентрикс, Инк. Аза-арил-1Н-пиразол-1-ил-сульфонамиды
US9715915B2 (en) 2014-10-30 2017-07-25 Samsung Electronics Co., Ltd. Magneto-resistive devices including a free layer having different magnetic properties during operations

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