ES2803524T3 - Formulaciones de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida del ácido ciclopropanocarboxílico - Google Patents
Formulaciones de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida del ácido ciclopropanocarboxílico Download PDFInfo
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- ES2803524T3 ES2803524T3 ES12766778T ES12766778T ES2803524T3 ES 2803524 T3 ES2803524 T3 ES 2803524T3 ES 12766778 T ES12766778 T ES 12766778T ES 12766778 T ES12766778 T ES 12766778T ES 2803524 T3 ES2803524 T3 ES 2803524T3
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201161534841P | 2011-09-14 | 2011-09-14 | |
| PCT/US2012/054990 WO2013040120A1 (en) | 2011-09-14 | 2012-09-13 | Formulations of cyclopropanecarboxylic acid {2-(1s)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}-amidecelgene corporation state of incorporation:delaware |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2803524T3 true ES2803524T3 (es) | 2021-01-27 |
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Family Applications (1)
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| EP (1) | EP2765993B1 (enExample) |
| JP (3) | JP2014526508A (enExample) |
| KR (1) | KR20140063808A (enExample) |
| CN (1) | CN105142615A (enExample) |
| AU (1) | AU2012308663B2 (enExample) |
| CA (1) | CA2848493A1 (enExample) |
| CL (1) | CL2014000623A1 (enExample) |
| ES (1) | ES2803524T3 (enExample) |
| IL (1) | IL231462A0 (enExample) |
| MX (1) | MX356105B (enExample) |
| PH (1) | PH12014500593A1 (enExample) |
| RU (2) | RU2017121896A (enExample) |
| SG (1) | SG11201400632YA (enExample) |
| WO (1) | WO2013040120A1 (enExample) |
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| ES2803524T3 (es) | 2011-09-14 | 2021-01-27 | Amgen Europe Gmbh | Formulaciones de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida del ácido ciclopropanocarboxílico |
| EP2764866A1 (en) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
| ES3041833T3 (en) | 2013-12-31 | 2025-11-14 | Ascendia Pharmaceuticals Llc | Pharmaceutical compositions for poorly water-soluble compounds |
| WO2015175505A1 (en) * | 2014-05-15 | 2015-11-19 | Lundbeck Llc | Tetrabenazine modified release formulation |
| WO2015175956A1 (en) * | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
| KR101722564B1 (ko) * | 2014-09-16 | 2017-04-03 | 강원대학교산학협력단 | 수-난용성 약물을 포함하는 고체분산체 |
| WO2016199927A1 (ja) * | 2015-06-12 | 2016-12-15 | 日産化学工業株式会社 | カルシウム塩組成物及びそれを用いたフィラグリン産生促進剤 |
| KR20200043618A (ko) * | 2018-10-18 | 2020-04-28 | 주식회사유한양행 | 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물 |
| AU2021351536A1 (en) * | 2020-10-01 | 2023-05-04 | Imago Biosciences, Inc. | Pharmaceutical formulations for treating diseases mediated by kdm1a |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| WO1995003807A1 (en) | 1993-07-27 | 1995-02-09 | The University Of Sydney | Treatment of age-related macular degeneration |
| US5801195A (en) * | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
| IT1274549B (it) | 1995-05-23 | 1997-07-17 | Indena Spa | Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno |
| US5800819A (en) | 1996-01-25 | 1998-09-01 | National Institute For Pharmaceutical Research And Development Federal Ministry Of Science And Technology | Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease |
| HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| CA2624949C (en) | 1996-07-24 | 2011-02-15 | Celgene Corporation | Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing tnf.alpha. levels |
| HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
| US6015803A (en) | 1998-05-04 | 2000-01-18 | Wirostko; Emil | Antibiotic treatment of age-related macular degeneration |
| US6225348B1 (en) | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
| US6001368A (en) | 1998-09-03 | 1999-12-14 | Protein Technologies International, Inc. | Method for inhibiting or reducing the risk of macular degeneration |
| US6667316B1 (en) * | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
| US20040190609A1 (en) | 2001-11-09 | 2004-09-30 | Yasuhiko Watanabe | Moving picture coding method and apparatus |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US20100129363A1 (en) | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US20050203142A1 (en) | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
| US20040091455A1 (en) | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US20050100529A1 (en) | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| JP5089170B2 (ja) | 2003-12-02 | 2012-12-05 | セルジーン コーポレイション | 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物 |
| US20050143344A1 (en) | 2003-12-30 | 2005-06-30 | Zeldis Jerome B. | Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases |
| NZ550026A (en) | 2004-03-22 | 2009-10-30 | Celgene Corp | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders |
| US20050222209A1 (en) | 2004-04-01 | 2005-10-06 | Zeldis Jerome B | Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease |
| BRPI0510110A (pt) | 2004-04-23 | 2007-09-25 | Celgene Corp | método para tratar, prevenir ou controlar hipertensão pulmonar, e, composição farmacêutica |
| WO2007001451A2 (en) * | 2004-11-09 | 2007-01-04 | Board Of Regents, The University Of Texas System | Stabilized hme composition with small drug particles |
| KR20070086000A (ko) | 2004-11-12 | 2007-08-27 | 셀진 코포레이션 | 기생충성 질병의 치료 및 관리를 위한 면역조절성 화합물을사용하는 방법 및 조성물 |
| EP1827431A1 (en) | 2004-11-23 | 2007-09-05 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury |
| DE602006020300D1 (de) | 2005-09-01 | 2011-04-07 | Celgene Corp | Immunologische verwendungen von immunmodulatorischen verbindungen für einen impfstoff und therapie gegen infektionskrankheiten |
| JP2010526848A (ja) * | 2007-05-11 | 2010-08-05 | エフ．ホフマン−ラ ロシュ アーゲー | 難溶性薬物用の医薬組成物 |
| US20110053942A1 (en) * | 2008-02-13 | 2011-03-03 | Dainippon Sumitomo Pharma Co., Ltd. | Orally disintegrating tablets |
| WO2009120296A1 (en) * | 2008-03-24 | 2009-10-01 | Celgene Corporation | Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| BRPI0917358A2 (pt) * | 2008-08-20 | 2015-11-17 | Univ Texas | formulação farmacêutica de liberação controlada e método. |
| CN102209709B (zh) | 2008-09-10 | 2014-08-13 | 细胞基因公司 | 制备氨基砜化合物的方法 |
| CA2750123A1 (en) | 2009-02-10 | 2010-08-19 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
| EP2498753B1 (en) * | 2009-11-10 | 2019-03-06 | Celgene Corporation | Nanosuspension of a poorly soluble drug made by microfluidization process |
| EP2506835B1 (en) * | 2009-11-30 | 2019-06-12 | Adare Pharmaceuticals, Inc. | Compressible-coated pharmaceutical compositions and tablets and methods of manufacture |
| US9757355B2 (en) * | 2011-01-10 | 2017-09-12 | Celgene Corporation | Oral dosage forms of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide |
| ES2803524T3 (es) | 2011-09-14 | 2021-01-27 | Amgen Europe Gmbh | Formulaciones de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida del ácido ciclopropanocarboxílico |
| CN104136003A (zh) | 2011-12-27 | 2014-11-05 | 细胞基因公司 | (+)-2-[1-(3-乙氧基-4-甲氧基-苯基)-2-甲磺酰基-乙基]-4-乙酰氨基异二氢吲哚-1,3-二酮的制剂 |
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2012
- 2012-09-13 ES ES12766778T patent/ES2803524T3/es active Active
- 2012-09-13 CN CN201280055703.3A patent/CN105142615A/zh active Pending
- 2012-09-13 WO PCT/US2012/054990 patent/WO2013040120A1/en not_active Ceased
- 2012-09-13 KR KR1020147009799A patent/KR20140063808A/ko not_active Ceased
- 2012-09-13 MX MX2014003261A patent/MX356105B/es active IP Right Grant
- 2012-09-13 RU RU2017121896A patent/RU2017121896A/ru unknown
- 2012-09-13 EP EP12766778.0A patent/EP2765993B1/en active Active
- 2012-09-13 PH PH1/2014/500593A patent/PH12014500593A1/en unknown
- 2012-09-13 SG SG11201400632YA patent/SG11201400632YA/en unknown
- 2012-09-13 RU RU2014114499A patent/RU2627471C2/ru active
- 2012-09-13 JP JP2014530765A patent/JP2014526508A/ja not_active Ceased
- 2012-09-13 CA CA2848493A patent/CA2848493A1/en not_active Abandoned
- 2012-09-13 US US14/344,870 patent/US9884042B2/en active Active
- 2012-09-13 AU AU2012308663A patent/AU2012308663B2/en active Active
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- 2014-03-14 CL CL2014000623A patent/CL2014000623A1/es unknown
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2017
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- 2017-05-26 JP JP2017104141A patent/JP2017178961A/ja active Pending
Also Published As
| Publication number | Publication date |
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| RU2014114499A (ru) | 2015-10-20 |
| JP2014526508A (ja) | 2014-10-06 |
| WO2013040120A1 (en) | 2013-03-21 |
| US9884042B2 (en) | 2018-02-06 |
| MX2014003261A (es) | 2014-04-10 |
| JP2017178961A (ja) | 2017-10-05 |
| JP6339251B2 (ja) | 2018-06-06 |
| AU2012308663B2 (en) | 2017-06-08 |
| RU2017121896A (ru) | 2019-01-29 |
| HK1200356A1 (en) | 2015-08-07 |
| JP2017105804A (ja) | 2017-06-15 |
| IL231462A0 (en) | 2014-04-30 |
| US20150190374A1 (en) | 2015-07-09 |
| EP2765993A1 (en) | 2014-08-20 |
| SG11201400632YA (en) | 2014-04-28 |
| MX356105B (es) | 2018-05-14 |
| KR20140063808A (ko) | 2014-05-27 |
| PH12014500593A1 (en) | 2019-09-02 |
| CL2014000623A1 (es) | 2014-11-07 |
| EP2765993B1 (en) | 2020-05-20 |
| CN105142615A (zh) | 2015-12-09 |
| AU2012308663A1 (en) | 2014-04-03 |
| RU2627471C2 (ru) | 2017-08-08 |
| CA2848493A1 (en) | 2013-03-21 |
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