ES2763156T3 - Inducción apoptótica selectiva en células cancerosas incluyendo la activación de procaspasa-3 - Google Patents
Inducción apoptótica selectiva en células cancerosas incluyendo la activación de procaspasa-3 Download PDFInfo
- Publication number
- ES2763156T3 ES2763156T3 ES06771588T ES06771588T ES2763156T3 ES 2763156 T3 ES2763156 T3 ES 2763156T3 ES 06771588 T ES06771588 T ES 06771588T ES 06771588 T ES06771588 T ES 06771588T ES 2763156 T3 ES2763156 T3 ES 2763156T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- procaspase
- pac
- cancer
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- YQNRVGJCPCNMKT-LFVJCYFKSA-N C=CCc1cccc(/C=N/NC(CN2CCN(Cc3ccccc3)CC2)=O)c1O Chemical compound C=CCc1cccc(/C=N/NC(CN2CCN(Cc3ccccc3)CC2)=O)c1O YQNRVGJCPCNMKT-LFVJCYFKSA-N 0.000 description 1
- PHMKEEBFHCHAHN-FYJGNVAPSA-N Oc1c(/C=N/NC(CN2CCN(CC3=CC=[I]C=C3)CC2)=O)cccc1 Chemical compound Oc1c(/C=N/NC(CN2CCN(CC3=CC=[I]C=C3)CC2)=O)cccc1 PHMKEEBFHCHAHN-FYJGNVAPSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68480705P | 2005-05-26 | 2005-05-26 | |
| US74387806P | 2006-03-28 | 2006-03-28 | |
| US11/420,425 US20070049602A1 (en) | 2005-05-26 | 2006-05-25 | Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3 |
| PCT/US2006/020910 WO2006128173A2 (en) | 2005-05-26 | 2006-05-26 | Selective apoptotic induction in cancer cells including activation of procaspase-3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2763156T3 true ES2763156T3 (es) | 2020-05-27 |
Family
ID=37452994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06771588T Active ES2763156T3 (es) | 2005-05-26 | 2006-05-26 | Inducción apoptótica selectiva en células cancerosas incluyendo la activación de procaspasa-3 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070049602A1 (enExample) |
| EP (3) | EP2634581A1 (enExample) |
| JP (2) | JP5513741B2 (enExample) |
| AU (1) | AU2006251978A1 (enExample) |
| CA (1) | CA2610366A1 (enExample) |
| DK (1) | DK1893210T3 (enExample) |
| ES (1) | ES2763156T3 (enExample) |
| IL (1) | IL187603A0 (enExample) |
| MX (1) | MX2007014843A (enExample) |
| WO (1) | WO2006128173A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070049602A1 (en) * | 2005-05-26 | 2007-03-01 | The Board Of Trustees Of The University Of Illinois | Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3 |
| WO2008134474A2 (en) * | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| WO2010091382A1 (en) | 2009-02-09 | 2010-08-12 | The Board Of Trustees Of The University Of Illinois | Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs |
| WO2010102513A1 (zh) * | 2009-03-11 | 2010-09-16 | 深圳市湘雅生物医药研究院 | 高哌嗪乙酰肼类衍生物及其制备方法和用途 |
| CN101805338B (zh) * | 2010-04-06 | 2014-10-15 | 沈阳药科大学 | 噁二唑基哌嗪衍生物及其用途 |
| US8916705B2 (en) * | 2011-10-14 | 2014-12-23 | The Board of Trustees of The University of Illilnois | Procaspase-activating compounds and compositions |
| EP2819661B1 (en) | 2012-03-02 | 2016-11-09 | The Board of Trustees of the University of Illionis | Potent anticancer activity via dual compound activation |
| MX365392B (es) * | 2012-03-06 | 2019-05-31 | Univ Illinois | Composición de combinación de pac-1 y doxorrubicina. |
| JP6222608B2 (ja) * | 2012-03-06 | 2017-11-01 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 膠芽腫のためのプロカスパーゼ併用療法 |
| US9249116B2 (en) * | 2012-08-03 | 2016-02-02 | The Board Of Trustees Of The University Of Illinois | Enzyme-activating compounds and compositions |
| CN105218399B (zh) | 2014-05-30 | 2018-02-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种取代乙酰肼类衍生物、其制备方法及用途 |
| WO2016197129A1 (en) | 2015-06-05 | 2016-12-08 | The Board Of Trustees Of The University Of Illinois | Pac-1 combination therapy |
| EP3326631B1 (en) * | 2015-07-23 | 2021-07-14 | Zhimin Wang | Compound pac-1 or salt thereof, and pharmaceutical composition comprising same |
| WO2017015784A1 (zh) * | 2015-07-24 | 2017-02-02 | 深圳市湘雅生物医药研究院 | 奥比特嗪-富马酸盐、水合物、晶型及其制备方法 |
| CN105085421B (zh) * | 2015-07-24 | 2017-12-26 | 深圳市湘雅生物医药研究院 | 奥比特嗪‑富马酸盐、水合物、晶型及其制备方法 |
| AU2018368453B2 (en) * | 2017-11-17 | 2024-05-30 | The Board Of Trustees Of The University Of Illinois | Cancer therapy by degrading dual MEK signaling |
| KR20210084442A (ko) | 2018-10-05 | 2021-07-07 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 포도막 흑색종 치료를 위한 병용 요법 |
| WO2025129066A1 (en) * | 2023-12-15 | 2025-06-19 | The Regents Of The University Of California | Detection, prevention, and reversal of acquired resistance to immune checkpoint blockade therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4068666B2 (ja) * | 1997-05-22 | 2008-03-26 | ザ バーナム インスティチュート | カスパーゼ活性のアポトーシスインヒビター（ｉａｐ）タンパク質調節を変える薬剤についてのスクリーニングアッセイ |
| US6403765B1 (en) | 1998-06-16 | 2002-06-11 | Thomas Jefferson University | Truncated Apaf-1 and methods of use thereof |
| AU5205499A (en) | 1998-07-27 | 2000-02-21 | Pharmacia & Upjohn Company | Method for autoactivation of procaspase 8 |
| US6110691A (en) | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
| US6608026B1 (en) | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
| WO2002048329A2 (en) | 2000-11-20 | 2002-06-20 | Idun Pharmaceuticals, Inc. | Membrane derived caspase-3, compositions comprising the same and methods of use therefor |
| WO2002069995A2 (en) * | 2001-02-16 | 2002-09-12 | Medical College Of Georgia Research Institute, Inc. | Use of trail and antiprogestins for treating cancer |
| KR100439425B1 (ko) * | 2001-03-22 | 2004-07-05 | (주)바이오케어 | 잔토리졸을 포함하는 조성물 및 그 용도 |
| US6878743B2 (en) | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| CA2508690A1 (en) * | 2002-12-10 | 2004-06-24 | Ottawa Health Research Institute | Modulation of stem cell differentiation by modulation of caspase-3 activity |
| WO2004066958A2 (en) | 2003-01-30 | 2004-08-12 | The Trustees Of Princeton University | Caspase-9:bir3 domain of xiap complexes and methods of use |
| US20070049602A1 (en) * | 2005-05-26 | 2007-03-01 | The Board Of Trustees Of The University Of Illinois | Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3 |
-
2006
- 2006-05-25 US US11/420,425 patent/US20070049602A1/en not_active Abandoned
- 2006-05-26 CA CA002610366A patent/CA2610366A1/en not_active Abandoned
- 2006-05-26 WO PCT/US2006/020910 patent/WO2006128173A2/en not_active Ceased
- 2006-05-26 JP JP2008513829A patent/JP5513741B2/ja active Active
- 2006-05-26 EP EP13166147.2A patent/EP2634581A1/en not_active Withdrawn
- 2006-05-26 MX MX2007014843A patent/MX2007014843A/es not_active Application Discontinuation
- 2006-05-26 DK DK06771588.8T patent/DK1893210T3/da active
- 2006-05-26 ES ES06771588T patent/ES2763156T3/es active Active
- 2006-05-26 EP EP06771588.8A patent/EP1893210B1/en active Active
- 2006-05-26 EP EP13166145.6A patent/EP2659884A3/en not_active Withdrawn
- 2006-05-26 AU AU2006251978A patent/AU2006251978A1/en not_active Abandoned
-
2007
- 2007-11-25 IL IL187603A patent/IL187603A0/en unknown
-
2012
- 2012-11-15 JP JP2012251584A patent/JP5907852B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007014843A (es) | 2008-02-14 |
| AU2006251978A1 (en) | 2006-11-30 |
| EP2634581A1 (en) | 2013-09-04 |
| EP1893210A4 (en) | 2010-09-01 |
| JP5907852B2 (ja) | 2016-04-26 |
| WO2006128173A3 (en) | 2007-05-24 |
| WO2006128173A2 (en) | 2006-11-30 |
| DK1893210T3 (da) | 2020-01-13 |
| EP2659884A3 (en) | 2014-10-01 |
| CA2610366A1 (en) | 2006-11-30 |
| EP1893210B1 (en) | 2019-10-02 |
| EP1893210A2 (en) | 2008-03-05 |
| JP5513741B2 (ja) | 2014-06-04 |
| US20070049602A1 (en) | 2007-03-01 |
| JP2008545718A (ja) | 2008-12-18 |
| IL187603A0 (en) | 2008-03-20 |
| JP2013100285A (ja) | 2013-05-23 |
| EP2659884A2 (en) | 2013-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2763156T3 (es) | Inducción apoptótica selectiva en células cancerosas incluyendo la activación de procaspasa-3 | |
| US11612598B2 (en) | Compounds and methods for the treatment of cancer | |
| Chen et al. | The V-ATPases in cancer and cell death | |
| Yuan et al. | Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy | |
| ES2303096T3 (es) | Derivados del catecol para el tratamiento del cancer. | |
| He et al. | Targeting cullin neddylation for cancer and fibrotic diseases | |
| DK2822546T3 (en) | PROCASPACE COMBINATION THERAPY FOR CANCER TREATMENT | |
| Hockenbery et al. | Mitochondria and apoptosis: new therapeutic targets | |
| Miao et al. | A novel harmine derivative, N-(4-(hydroxycarbamoyl) benzyl)-1-(4-methoxyphenyl)-9H-pyrido [3, 4-b] indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects | |
| KR20210027382A (ko) | 접히지 않은 단백질 반응의 활성화제 | |
| BRPI0708307B1 (pt) | Combinação farmacêutica para administração simultânea, separada ou sequencial, e, uso de um peptídeo como inibidor do sítio de fosforilação sobre os substratos de CK2 e um citostático farmaceuticamente aceitável | |
| CN101184491A (zh) | 包括活化半胱天冬酶-3酶原的癌细胞内选择性细胞凋亡诱导 | |
| US20180296548A1 (en) | Aminothiolester compounds or pharmaceutically acceptable salts thereof, for use in the treatment of cancer | |
| EP4132657A1 (en) | Compositions and methods for treatment of anticancer-drug resistant cancers | |
| ES2396115T3 (es) | Uso de inhibidores de la degradación de p27, en particular argirina y derivados de la misma, para el tratamiento del cáncer | |
| KR101400505B1 (ko) | Ｐ５３ 기능을 대체하거나 작동시키는 소형 분자 | |
| WO2004039797A1 (en) | A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer | |
| Zhou et al. | A novel 1, 8-naphthalimide-piperazine-amidobenzenesulfonamide derivative targets carbonic anhydrase IX to induce ferroptosis, apoptosis and autophagy in colorectal cancer cells | |
| WO2024227168A1 (en) | Structure-based optimization of s6k2 inhibitor cd02 to target melanoma | |
| GR20180100521A (el) | Αναστολεις και ιχνηθετες ενεργοτητας της πρωτεασης klk7 με διττες εφαρμογες στη διαγνωση και θεραπεια | |
| BR112018007310B1 (pt) | Método in vitro para selecionar um indivíduo que sofre de um câncer | |
| HK1251476B (en) | Aminothiolester compounds or pharmaceutically acceptable salts thereof, for use in the treatment of cancer |