ES274932A1 - New antibiotic and production thereof - Google Patents

New antibiotic and production thereof

Info

Publication number
ES274932A1
ES274932A1 ES0274932A ES274932A ES274932A1 ES 274932 A1 ES274932 A1 ES 274932A1 ES 0274932 A ES0274932 A ES 0274932A ES 274932 A ES274932 A ES 274932A ES 274932 A1 ES274932 A1 ES 274932A1
Authority
ES
Spain
Prior art keywords
antibiotic
pyridine
produced
dimethylformamide
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0274932A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES274932A1 publication Critical patent/ES274932A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

<PICT:0945583/C2/1> Relates to a new antibiotic designated 9671 RP which is a yellow substance crystallizing as fine needles, melting point 310-320 DEG C. with decomposition, having an optical rotation [a ]20D = +38 DEG (C=1, pyridine), analysing C 49.6%, H 4.0%, O 16.7%, N 14.4%, S 15.75-15.80%, having an ultraviolet spectrum in solution in water containing dimethylformamide exhibiting two absorption maxima at 242 mm (E1%1cm=525) and 322 mm (E1%1cm=229), having the infra-red absorption spectrum shown in the figure, and being soluble in chloroform, dioxane, pyridine, dimethylformamide and dimethylsulphoxide, slightly soluble in methanol, ethanol, ethyl acetate and benzene, and insoluble in water and petroleum ether. The antibiotic may be produced by culturing Streptomyces actuosus Nov. spec. NRRL 2954 on a nutrient medium and separating from the culture the antibiotic so produced, preferably by extraction with an organic solvent. The antibiotic may be purified by crystallization from acetic acid with or without preliminary treatments by washing and chromotography using a column of alumina. The antibiotic 9671 RP may be used to form pharmaceutical compositions in association with a pharmaceutical carrier, these compositions being normally administered topically.
ES0274932A 1961-02-24 1962-02-24 New antibiotic and production thereof Expired ES274932A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR853794A FR1392453A (en) 1961-02-24 1961-02-24 New antibiotic and its method of preparation by fermentation of streptomyces actuosus

Publications (1)

Publication Number Publication Date
ES274932A1 true ES274932A1 (en) 1962-05-01

Family

ID=8749601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0274932A Expired ES274932A1 (en) 1961-02-24 1962-02-24 New antibiotic and production thereof

Country Status (7)

Country Link
BR (1) BR6236595D0 (en)
CH (1) CH415958A (en)
DK (1) DK103826C (en)
ES (1) ES274932A1 (en)
FR (1) FR1392453A (en)
GB (1) GB945583A (en)
LU (1) LU41096A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6011012B2 (en) * 1975-10-28 1985-03-22 クミアイ化学工業株式会社 Growth promoters for pigs and poultry, and egg production promoters for poultry
JPS61293921A (en) * 1986-05-09 1986-12-24 Kumiai Chem Ind Co Ltd Growth-promoting agent for pig

Also Published As

Publication number Publication date
GB945583A (en) 1964-01-02
CH415958A (en) 1966-06-30
LU41096A1 (en) 1962-03-15
DK103826C (en) 1966-02-28
BR6236595D0 (en) 1973-06-14
FR1392453A (en) 1965-03-19

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