ES2720582T3 - Tejido biológico reforzado - Google Patents
Tejido biológico reforzado Download PDFInfo
- Publication number
- ES2720582T3 ES2720582T3 ES07797396T ES07797396T ES2720582T3 ES 2720582 T3 ES2720582 T3 ES 2720582T3 ES 07797396 T ES07797396 T ES 07797396T ES 07797396 T ES07797396 T ES 07797396T ES 2720582 T3 ES2720582 T3 ES 2720582T3
- Authority
- ES
- Spain
- Prior art keywords
- tissue
- component
- biological
- biological component
- medical device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002131 composite material Substances 0.000 claims abstract description 38
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 3
- 210000001519 tissue Anatomy 0.000 claims description 132
- 239000011159 matrix material Substances 0.000 claims description 27
- 210000004872 soft tissue Anatomy 0.000 claims description 12
- 230000017423 tissue regeneration Effects 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 229920001610 polycaprolactone Polymers 0.000 claims description 5
- 239000004632 polycaprolactone Substances 0.000 claims description 5
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 4
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 4
- 239000004626 polylactic acid Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 3
- 239000000622 polydioxanone Substances 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000011888 foil Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 41
- 239000000463 material Substances 0.000 description 38
- 238000002513 implantation Methods 0.000 description 26
- 210000003041 ligament Anatomy 0.000 description 22
- 108010035532 Collagen Proteins 0.000 description 20
- 102000008186 Collagen Human genes 0.000 description 20
- 229920001436 collagen Polymers 0.000 description 19
- 238000000034 method Methods 0.000 description 18
- 229920000642 polymer Polymers 0.000 description 18
- 239000007943 implant Substances 0.000 description 17
- 239000004744 fabric Substances 0.000 description 16
- 239000002245 particle Substances 0.000 description 16
- 210000002435 tendon Anatomy 0.000 description 15
- 238000011068 loading method Methods 0.000 description 13
- 210000001264 anterior cruciate ligament Anatomy 0.000 description 12
- 210000002469 basement membrane Anatomy 0.000 description 12
- 238000010276 construction Methods 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000007423 decrease Effects 0.000 description 8
- 239000004753 textile Substances 0.000 description 8
- 241000288906 Primates Species 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 238000006731 degradation reaction Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000008439 repair process Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 239000012620 biological material Substances 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- -1 polyethylene Polymers 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000004207 dermis Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 108010023728 Alloderm Proteins 0.000 description 4
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 4
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000005138 cryopreservation Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000002500 effect on skin Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 230000005226 mechanical processes and functions Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 229920002994 synthetic fiber Polymers 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 3
- 239000005913 Maltodextrin Substances 0.000 description 3
- 229920000954 Polyglycolide Polymers 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 238000004873 anchoring Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000002577 cryoprotective agent Substances 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 210000003709 heart valve Anatomy 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- 239000011261 inert gas Substances 0.000 description 3
- 229940035034 maltodextrin Drugs 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000004633 polyglycolic acid Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000007634 remodeling Methods 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 230000008718 systemic inflammatory response Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 108010085626 Cymetra Proteins 0.000 description 2
- 241001269524 Dura Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000002464 Galactosidases Human genes 0.000 description 2
- 108010093031 Galactosidases Proteins 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920001710 Polyorthoester Polymers 0.000 description 2
- 102000016611 Proteoglycans Human genes 0.000 description 2
- 108010067787 Proteoglycans Proteins 0.000 description 2
- 239000004775 Tyvek Substances 0.000 description 2
- 229920000690 Tyvek Polymers 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 210000001196 cardiac muscle myoblast Anatomy 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000001612 chondrocyte Anatomy 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 230000008467 tissue growth Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 210000000626 ureter Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000282817 Bovidae Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 229920002101 Chitin Chemical class 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000004510 Collagen Type VII Human genes 0.000 description 1
- 108010017377 Collagen Type VII Proteins 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010073385 Fibrin Chemical class 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical class CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000699694 Gerbillinae Species 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 241000906034 Orthops Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288935 Platyrrhini Species 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Chemical class 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000002358 autolytic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000005068 bladder tissue Anatomy 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- LBAYFEDWGHXMSM-UHFFFAOYSA-N butaneperoxoic acid Chemical compound CCCC(=O)OO LBAYFEDWGHXMSM-UHFFFAOYSA-N 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 239000002975 chemoattractant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000000959 cryoprotective effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000009746 freeze damage Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001648 gingival epithelial cell Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000012606 in vitro cell culture Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 108091005573 modified proteins Chemical class 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 108010008217 nidogen Proteins 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 210000000426 patellar ligament Anatomy 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000003668 pericyte Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000002379 periodontal ligament Anatomy 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000232 polyglycine polymer Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000000050 smooth muscle relaxant Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 210000001644 umbilical artery Anatomy 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
- A61F2/0811—Fixation devices for tendons or ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3662—Ligaments, tendons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
- A61F2/0805—Implements for inserting tendons or ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
- A61F2/0811—Fixation devices for tendons or ligaments
- A61F2002/0847—Mode of fixation of anchor to tendon or ligament
- A61F2002/0858—Fixation of tendon or ligament between anchor and bone, e.g. interference screws, wedges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Botany (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79910206P | 2006-05-09 | 2006-05-09 | |
| PCT/US2007/068607 WO2007134134A2 (en) | 2006-05-09 | 2007-05-09 | Reinforced biological tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2720582T3 true ES2720582T3 (es) | 2019-07-23 |
Family
ID=38694686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07797396T Active ES2720582T3 (es) | 2006-05-09 | 2007-05-09 | Tejido biológico reforzado |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9339369B2 (enExample) |
| EP (2) | EP3505137A1 (enExample) |
| JP (1) | JP5244093B2 (enExample) |
| CN (1) | CN101553189A (enExample) |
| ES (1) | ES2720582T3 (enExample) |
| WO (1) | WO2007134134A2 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008076330A1 (en) * | 2006-12-15 | 2008-06-26 | Soteira, Inc. | Drills and methods for vertebrostenting |
| US9480485B2 (en) | 2006-12-15 | 2016-11-01 | Globus Medical, Inc. | Devices and methods for vertebrostenting |
| US8753391B2 (en) * | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
| US9382422B2 (en) | 2007-07-10 | 2016-07-05 | Lifecell Corporation | Acellular tissue matrix compositions for tissue repair |
| US20090018655A1 (en) * | 2007-07-13 | 2009-01-15 | John Brunelle | Composite Implant for Surgical Repair |
| JP5341907B2 (ja) * | 2007-11-14 | 2013-11-13 | パトリック マックスウェル、ジー | インターフェースを有する医療用インプラント組立体 |
| AU2009205429A1 (en) | 2008-01-14 | 2009-07-23 | Conventus Orthopaedics Inc. | Apparatus and methods for fracture repair |
| ES2641913T3 (es) | 2008-03-27 | 2017-11-14 | Cleveland Clinic Foundation | Injerto de tejido reforzado |
| US20130116799A1 (en) | 2008-03-27 | 2013-05-09 | The Cleveland Clinic Foundation | Reinforced tissue graft |
| US20100082113A1 (en) * | 2008-04-29 | 2010-04-01 | Peter Gingras | Tissue repair implant |
| US20090276044A1 (en) * | 2008-04-30 | 2009-11-05 | Exploramed Nc4, Inc. | Sheaths for extra-articular implantable systems |
| WO2009155319A1 (en) * | 2008-06-17 | 2009-12-23 | Soteira, Inc. | Devices and methods for fracture reduction |
| EP2319548B1 (en) * | 2008-08-14 | 2016-06-01 | KCI Licensing, Inc. | Tissue scaffolds |
| US9387280B2 (en) | 2008-09-05 | 2016-07-12 | Synovis Orthopedic And Woundcare, Inc. | Device for soft tissue repair or replacement |
| US8858698B2 (en) | 2008-09-05 | 2014-10-14 | Mentor Worldwide Llc | Acellular matrix glue |
| KR20110105778A (ko) * | 2008-11-20 | 2011-09-27 | 라이프셀 코포레이션 | 장루 주위 탈장을 치료하고 예방하는 방법 |
| AU2009316588B2 (en) * | 2008-11-21 | 2014-09-11 | Stout Medical Group, L.P. | Reinforced biologic material |
| CA2746627A1 (en) * | 2008-12-19 | 2010-06-24 | C.R. Bard, Inc. | Implantable prosthesis |
| US8469779B1 (en) | 2009-01-02 | 2013-06-25 | Lifecell Corporation | Method for debristling animal skin |
| US9339370B2 (en) * | 2009-04-22 | 2016-05-17 | The Cleveland Clinic Foundation | Apparatus and method for sequentially anchoring multiple graft ligaments in a bone tunnel |
| US8986377B2 (en) * | 2009-07-21 | 2015-03-24 | Lifecell Corporation | Graft materials for surgical breast procedures |
| ES2644599T3 (es) * | 2009-09-02 | 2017-11-29 | Lifecell Corporation | Injertos vasculares procedentes de matrices de tejido acelular |
| US9649408B1 (en) | 2009-11-05 | 2017-05-16 | Lifecell Corporation | Systems and methods for sterilization of bone or bone components |
| EP2523614A4 (en) | 2010-01-15 | 2017-02-15 | Conventus Orthopaedics, Inc. | Rotary-rigid orthopaedic rod |
| CN105534561B (zh) | 2010-01-20 | 2018-04-03 | 康文图斯整形外科公司 | 用于骨接近和骨腔准备的装置及方法 |
| US10448951B2 (en) * | 2010-02-19 | 2019-10-22 | Lifecell Corporation | Abdominal wall treatment devices |
| JP2013521880A (ja) | 2010-03-08 | 2013-06-13 | コンベンタス オーソピディックス， インコーポレイテッド | 骨インプラントを固定するための装置および方法 |
| EP2550028B1 (en) * | 2010-03-25 | 2018-03-07 | Lifecell Corporation | Preparation of regenerative tissue scaffolds |
| ES2759445T3 (es) | 2010-07-08 | 2020-05-11 | Lifecell Corp | Procedimiento de formación de matrices de tejido |
| ES2662331T3 (es) * | 2010-08-10 | 2018-04-06 | Lifecell Corporation | Matrices tisulares regenerativas |
| EP2608814B1 (en) | 2010-08-26 | 2020-04-15 | LifeCell Corporation | Passive methods for anti-microbial biological meshes |
| US8637067B1 (en) | 2011-03-10 | 2014-01-28 | Lifecell Corporation | Elastic tissue matrix derived hydrogel |
| CA2832838C (en) | 2011-04-14 | 2019-08-13 | Lifecell Corporation | Regenerative tissue matrix flakes |
| AU2012262311B2 (en) | 2011-05-31 | 2016-04-28 | Lifecell Corporation | Adipose tissue matrices |
| US20130018393A1 (en) * | 2011-07-12 | 2013-01-17 | Bengtson Bradley P | Surgical fixation devices, systems, and methods |
| US9089523B2 (en) | 2011-07-28 | 2015-07-28 | Lifecell Corporation | Natural tissue scaffolds as tissue fillers |
| CA2854885C (en) | 2011-11-10 | 2020-08-25 | Lifecell Corporation | Device for tendon and ligament treatment |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| ES2726105T3 (es) | 2011-12-20 | 2019-10-01 | Lifecell Corp | Productos de tejido fluidizable |
| EP3549615B1 (en) | 2011-12-20 | 2020-12-16 | LifeCell Corporation | Sheet tissue products |
| US8945025B2 (en) | 2011-12-30 | 2015-02-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter with atraumatic tip |
| AU2013212592B2 (en) | 2012-01-24 | 2016-06-30 | Lifecell Corporation | Elongated tissue matrices |
| ES2716993T3 (es) | 2012-03-08 | 2019-06-18 | Lifecell Corp | Matrices de colágeno y tejido activadas por enzimas |
| AU2013251800B2 (en) | 2012-04-24 | 2016-09-29 | Lifecell Corporation | Flowable tissue matrices |
| WO2013162997A1 (en) | 2012-04-24 | 2013-10-31 | Lifecell Corporation | Functionalized tissue matrices |
| EP2869861B1 (en) | 2012-07-05 | 2018-04-11 | Lifecell Corporation | Tissue-based drain manifolds |
| CA2878446A1 (en) | 2012-07-13 | 2014-01-16 | Lifecell Corporation | Methods for improved treatment of adipose tissue |
| ES2849440T3 (es) | 2012-09-26 | 2021-08-18 | Lifecell Corp | Tejido adiposo procesado |
| EP2951193A4 (en) | 2013-02-01 | 2017-03-01 | Children's Medical Center Corporation | Collagen scaffolds |
| CN104994893B (zh) | 2013-02-06 | 2018-01-05 | 生命细胞公司 | 用于组织产物的局部改性的方法 |
| AU2014362251B2 (en) | 2013-12-12 | 2019-10-10 | Conventus Orthopaedics, Inc. | Tissue displacement tools and methods |
| RU2016136578A (ru) * | 2014-02-13 | 2018-03-19 | Антонио САМБУССЕТИ | Неабсорбируемое устройство для восстановления тканей, в частности таких тканей, как связки |
| JP7307527B2 (ja) * | 2015-01-21 | 2023-07-12 | ライフセル コーポレーション | 制御された多孔性または機械的特性を有する組織マトリックス |
| WO2016186803A1 (en) | 2015-05-15 | 2016-11-24 | Lifecell Corporation | Tissue matrices for plastic surgery |
| EP3337427A1 (en) | 2015-08-21 | 2018-06-27 | Lifecell Corporation | Breast treatment device |
| US10675016B2 (en) | 2015-10-30 | 2020-06-09 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Suture sleeve patch and methods of delivery within an existing arthroscopic workflow |
| US11357495B2 (en) | 2016-02-01 | 2022-06-14 | Medos International Sarl | Tissue augmentation scaffolds for use with soft tissue fixation repair systems and methods |
| US20170273680A1 (en) | 2016-02-01 | 2017-09-28 | DePuy Synthes Products, Inc. | Tissue augmentation tacks for use with soft tissue fixation repair systems and methods |
| US11484401B2 (en) | 2016-02-01 | 2022-11-01 | Medos International Sarl | Tissue augmentation scaffolds for use in soft tissue fixation repair |
| US11179505B2 (en) | 2016-02-11 | 2021-11-23 | Lifecell Corporation | Methods for stabilizing collagen-containing tissue products against enzymatic degradation |
| WO2017143344A1 (en) | 2016-02-18 | 2017-08-24 | The Curators Of The University Of Missouri | Injectable nanomaterial-extracellular matrix constructs |
| PL232907B1 (pl) * | 2016-03-24 | 2019-08-30 | Robert Mrugas | Więzadło syntetyczne, sposób wytwarzania więzadła syntetycznego oraz jego zastosowanie |
| WO2017210109A1 (en) | 2016-06-03 | 2017-12-07 | Lifecell Corporation | Methods for localized modification of tissue products |
| CN105879119B (zh) * | 2016-06-06 | 2019-06-11 | 东华大学 | 一种复合脱细胞基质水凝胶及其制备方法 |
| CN106075582A (zh) * | 2016-06-27 | 2016-11-09 | 暨南大学 | 一种组织工程血管化支架及其构建方法 |
| ES2841427T3 (es) | 2016-07-05 | 2021-07-08 | Lifecell Corp | Matrices de tejido que incorporan múltiples tipos de tejido |
| CA3024196A1 (en) * | 2016-07-06 | 2018-01-11 | Children's Medical Center Corporation | Indirect method of articular tissue repair |
| DK3506854T3 (da) | 2016-08-31 | 2020-11-23 | Lifecell Corp | Brystbehandlingsindretning |
| US11045583B2 (en) | 2016-12-22 | 2021-06-29 | Lifecell Corporation | Devices and methods for tissue cryomilling |
| CN110573188B (zh) * | 2017-01-30 | 2022-02-01 | 生命细胞公司 | 包括肌肉基质的装置以及生产方法和用途 |
| WO2019010252A2 (en) | 2017-07-04 | 2019-01-10 | Conventus Orthopaedics, Inc. | Apparatus and methods for treatment of a bone |
| US11123375B2 (en) | 2017-10-18 | 2021-09-21 | Lifecell Corporation | Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products |
| WO2019079570A1 (en) | 2017-10-18 | 2019-04-25 | Lifecell Corporation | ADIPOSE TISSUE PRODUCTS AND METHODS OF PRODUCTION |
| US11246994B2 (en) | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
| ES2960617T3 (es) | 2017-10-19 | 2024-03-05 | Lifecell Corp | Productos de matriz de tejido acelular fluida y métodos de producción |
| IL278370B2 (en) | 2018-05-03 | 2024-02-01 | Collplant Ltd | Dermal fillers and their uses |
| WO2020227095A1 (en) | 2019-05-03 | 2020-11-12 | Lifecell Corporation | Breast treatment device |
| EP3976127B1 (en) | 2019-05-30 | 2025-09-24 | LifeCell Corporation | Biologic breast implant |
| US20230103592A1 (en) * | 2021-10-01 | 2023-04-06 | Ahmadreza Afshar | Surgical device and method for repairing damaged flexor tendons |
| EP4514415A1 (en) * | 2022-04-26 | 2025-03-05 | Lifenet Health | Soft tissue composite |
| CN115006592B (zh) * | 2022-06-15 | 2024-01-30 | 上海交通大学医学院附属第九人民医院 | 一种脱细胞真皮复合材料、制备方法及用途 |
| CN114984323B (zh) * | 2022-06-15 | 2023-09-12 | 上海交通大学医学院附属第九人民医院 | 一种腹壁缺损修复材料及制备方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3463158A (en) * | 1963-10-31 | 1969-08-26 | American Cyanamid Co | Polyglycolic acid prosthetic devices |
| US4187558A (en) * | 1977-10-25 | 1980-02-12 | Cutter Laboratories, Inc. | Prosthetic ligament |
| US4599084A (en) | 1983-05-24 | 1986-07-08 | American Hospital Supply Corp. | Method of using biological tissue to promote even bone growth |
| US4865871A (en) | 1983-08-23 | 1989-09-12 | Board Of Regents The University Of Texas System | Method for cryopreparing biological tissue |
| US4633873A (en) * | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
| IL76079A (en) | 1985-08-13 | 1991-03-10 | Univ Ramot | Collagen implants |
| FR2598311B1 (fr) | 1986-05-07 | 1988-09-09 | Laboureau Jacques | Instrument chirurgical de visee et de pose pour la plastie (ou remplacement prothetique) du ligament croise posterieur du genou |
| US5425766A (en) | 1987-03-09 | 1995-06-20 | Astra Tech Aktiebolag | Resorbable prosthesis |
| US5078744A (en) | 1987-09-04 | 1992-01-07 | Bio-Products, Inc. | Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| US5366616A (en) | 1987-12-15 | 1994-11-22 | Uop | Hydrocarbon conversion process using a chromium substituted molecular sieve |
| US5197983A (en) * | 1988-04-19 | 1993-03-30 | W. L. Gore & Associates, Inc. | Ligament and tendon prosthesis |
| US5026398A (en) * | 1988-07-01 | 1991-06-25 | The Minnesota Mining And Manufacturing Company | Abrasion resistant prosthetic device |
| US5024669A (en) * | 1988-09-09 | 1991-06-18 | Baxter International Inc. | Artificial ligament of differential weave structure |
| US5147400A (en) * | 1989-05-10 | 1992-09-15 | United States Surgical Corporation | Connective tissue prosthesis |
| US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| US8067149B2 (en) * | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
| US5281422A (en) * | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| GB2282328B (en) * | 1993-09-29 | 1997-10-08 | Johnson & Johnson Medical | Absorbable structures for ligament and tendon repair |
| ATE247933T1 (de) | 1994-06-06 | 2003-09-15 | Univ Case Western Reserve | Biomatrix für geweberegenaration |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| EP0915967A1 (en) | 1996-05-28 | 1999-05-19 | The Board Of Regents Of The University Of Michigan | Engineering oral tissues |
| JP2001509700A (ja) * | 1996-12-10 | 2001-07-24 | クック バイオテック、インク． | ステント移植片含有精製粘膜下組織 |
| AU740913B2 (en) | 1997-09-11 | 2001-11-15 | Purdue Research Foundation | Galactosidase modified submucosal tissue |
| US6933326B1 (en) | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
| GB9912240D0 (en) * | 1999-05-27 | 1999-07-28 | Smith & Nephew | Implantable medical devices |
| US20020133229A1 (en) * | 2000-03-24 | 2002-09-19 | Laurencin Cato T. | Ligament and tendon replacement constructs and methods for production and use thereof |
| ATE338519T1 (de) * | 2000-06-14 | 2006-09-15 | Teppo Jaervinen | Fixierungsanker |
| US6592622B1 (en) | 2000-10-24 | 2003-07-15 | Depuy Orthopaedics, Inc. | Apparatus and method for securing soft tissue to an artificial prosthesis |
| CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
| AU2002320517B2 (en) * | 2001-07-16 | 2008-03-13 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorable scaffolds |
| AU2002354913B2 (en) * | 2001-07-16 | 2008-07-17 | Depuy Products, Inc. | Unitary surgical device and method |
| US20030078659A1 (en) * | 2001-10-23 | 2003-04-24 | Jun Yang | Graft element |
| US6599319B2 (en) * | 2001-12-14 | 2003-07-29 | Celanese Advanced Materials, Inc. | Prosthetic ligament |
| US20030118560A1 (en) * | 2001-12-20 | 2003-06-26 | Kelly Sheila J. | Composite biocompatible matrices |
| CA2486919C (en) * | 2002-06-03 | 2011-03-15 | Nmt Medical, Inc. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
| US20040034418A1 (en) * | 2002-07-23 | 2004-02-19 | Shu-Tung Li | Membrane-reinforced implants |
| US7550004B2 (en) * | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
| US7824701B2 (en) * | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
| US20060083767A1 (en) * | 2003-02-27 | 2006-04-20 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| US8226715B2 (en) * | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
| AU2004259019B2 (en) | 2003-07-21 | 2010-09-23 | Lifecell Corporation | Acellular tissue matrices made from galactose alpha-1,3-galactose-deficient tissue |
| AU2005212335B2 (en) * | 2004-02-09 | 2010-01-28 | Cook Biotech, Inc. | Cast bioremodelable graft |
| US7252832B1 (en) | 2004-12-13 | 2007-08-07 | Biomet Sports Medicine, Inc. | Composite collagen material and method of forming same |
| EP1871306A4 (en) * | 2005-04-01 | 2012-03-21 | Univ Colorado | TRANSPLANTER FIXING DEVICE AND METHOD |
| US20060247776A1 (en) * | 2005-05-02 | 2006-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for augmenting intervertebral discs |
| US20070162124A1 (en) * | 2005-12-19 | 2007-07-12 | Whittaker Gregory R | Arthroscopic implants with integral fixation devices and method for use |
-
2007
- 2007-05-09 JP JP2009510162A patent/JP5244093B2/ja active Active
- 2007-05-09 ES ES07797396T patent/ES2720582T3/es active Active
- 2007-05-09 US US11/746,557 patent/US9339369B2/en not_active Expired - Fee Related
- 2007-05-09 EP EP18212730.8A patent/EP3505137A1/en not_active Withdrawn
- 2007-05-09 CN CNA2007800253499A patent/CN101553189A/zh active Pending
- 2007-05-09 EP EP07797396.4A patent/EP2015707B1/en not_active Not-in-force
- 2007-05-09 WO PCT/US2007/068607 patent/WO2007134134A2/en not_active Ceased
-
2016
- 2016-04-21 US US15/134,450 patent/US20160228235A1/en not_active Abandoned
-
2021
- 2021-02-16 US US17/177,040 patent/US20210161646A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101553189A (zh) | 2009-10-07 |
| US20160228235A1 (en) | 2016-08-11 |
| JP5244093B2 (ja) | 2013-07-24 |
| WO2007134134A2 (en) | 2007-11-22 |
| JP2009536567A (ja) | 2009-10-15 |
| US20210161646A1 (en) | 2021-06-03 |
| US9339369B2 (en) | 2016-05-17 |
| EP2015707A2 (en) | 2009-01-21 |
| EP2015707B1 (en) | 2019-01-23 |
| EP3505137A1 (en) | 2019-07-03 |
| EP2015707A4 (en) | 2011-09-14 |
| US20080027542A1 (en) | 2008-01-31 |
| WO2007134134A3 (en) | 2008-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2720582T3 (es) | Tejido biológico reforzado | |
| ES2662331T3 (es) | Matrices tisulares regenerativas | |
| ES2672622T3 (es) | Preparación de armazones tisulares regenerativos | |
| JP5784500B2 (ja) | 強化型生物由来物質 | |
| ES2655281T3 (es) | Tratamiento de elastasa de matrices tisulares | |
| ES2520019T3 (es) | Mejoras relativas a la descelularización de matrices de tejido para el implante de vejiga | |
| ES2672815T3 (es) | Remodelación de tejidos y órganos | |
| ES2330063T3 (es) | Matriz tisular acelular particulada. | |
| AU2002362932A1 (en) | Remodeling of tissues and organs | |
| US20160030487A1 (en) | Methods for selection of age-appropriate tissues | |
| WO2025226588A1 (en) | Artificial implants that promote neovascularization |