ES2720368T3 - Peptidoglicanos sintéticos de enlace a colágeno, preparación y método de utilización - Google Patents

Peptidoglicanos sintéticos de enlace a colágeno, preparación y método de utilización Download PDF

Info

Publication number
ES2720368T3
ES2720368T3 ES09725336T ES09725336T ES2720368T3 ES 2720368 T3 ES2720368 T3 ES 2720368T3 ES 09725336 T ES09725336 T ES 09725336T ES 09725336 T ES09725336 T ES 09725336T ES 2720368 T3 ES2720368 T3 ES 2720368T3
Authority
ES
Spain
Prior art keywords
collagen
peptide
sily
glycan
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09725336T
Other languages
English (en)
Spanish (es)
Inventor
Alyssa Panitch
John Paderi
Kinam Park
Katherine Stuart
Steve Higbee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ES2720368T3 publication Critical patent/ES2720368T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES09725336T 2008-03-27 2009-03-27 Peptidoglicanos sintéticos de enlace a colágeno, preparación y método de utilización Active ES2720368T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3993308P 2008-03-27 2008-03-27
US8198408P 2008-07-18 2008-07-18
PCT/US2009/038624 WO2009120995A2 (en) 2008-03-27 2009-03-27 Collagen-binding synthetic peptidoglycans, preparation, and methods of use

Publications (1)

Publication Number Publication Date
ES2720368T3 true ES2720368T3 (es) 2019-07-19

Family

ID=41114790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09725336T Active ES2720368T3 (es) 2008-03-27 2009-03-27 Peptidoglicanos sintéticos de enlace a colágeno, preparación y método de utilización

Country Status (15)

Country Link
US (4) US8846003B2 (enExample)
EP (1) EP2280720B1 (enExample)
JP (2) JP5740301B2 (enExample)
AU (4) AU2009228140B2 (enExample)
CA (1) CA2719254C (enExample)
CY (1) CY1121954T1 (enExample)
DK (1) DK2280720T3 (enExample)
ES (1) ES2720368T3 (enExample)
HR (1) HRP20190691T1 (enExample)
HU (1) HUE044239T2 (enExample)
LT (1) LT2280720T (enExample)
PL (1) PL2280720T3 (enExample)
PT (1) PT2280720T (enExample)
SI (1) SI2280720T1 (enExample)
WO (1) WO2009120995A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
SG187493A1 (en) 2008-01-18 2013-02-28 Univ Minnesota Stem cell aggregates and methods for making and using
HUE044239T2 (hu) 2008-03-27 2019-10-28 Purdue Research Foundation Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik
WO2010129547A1 (en) * 2009-05-04 2010-11-11 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
EP2548608B1 (en) 2010-03-19 2018-01-31 CosMED Pharmaceutical Co., Ltd. Proteoglycan-containing microneedle array
WO2011163492A1 (en) * 2010-06-23 2011-12-29 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for use in vascular intervention
US9173919B2 (en) * 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
US9217016B2 (en) * 2011-05-24 2015-12-22 Symic Ip, Llc Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use
EP2970509B1 (en) * 2013-03-15 2020-05-13 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
US20150044259A1 (en) * 2013-08-08 2015-02-12 Mauris N. DeSilva Scaffold for enhanced neural tissue regeneration
WO2015164822A1 (en) * 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
KR20170016857A (ko) 2014-05-12 2017-02-14 퍼듀 리서치 파운데이션 셀렉틴 및 icam/vcam 펩티드 리간드 접합체
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
JP6937696B2 (ja) 2015-02-06 2021-09-22 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 組織工学型の組織代替系
MX2017013196A (es) * 2015-04-17 2018-06-19 Symic Ip Llc Bioconjugados y usos de los mismos.
EP3337464B1 (en) * 2015-08-17 2022-03-09 The Johns Hopkins University In situ forming composite material for tissue restoration
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate
KR101807593B1 (ko) 2015-12-30 2017-12-11 포항공과대학교 산학협력단 흉터 최소화 상처 재생 촉진용 재조합 폴리펩타이드 및 이를 포함하는 생체 접착 소재
JP2020526493A (ja) 2017-07-07 2020-08-31 サイミック アイピー, エルエルシー 化学的に修飾された主鎖を有するバイオコンジュゲート
WO2019010484A2 (en) * 2017-07-07 2019-01-10 Symic Ip, Llc SYNTHETIC BIOCONJUGATES
EP3790602A1 (en) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP4531897A4 (en) * 2022-05-29 2026-07-29 Aleph Farms Ltd FIBRILLARY HYDROGEL AND ITS USES
AU2023352919A1 (en) 2022-09-29 2025-03-13 Adora Life Science, Inc. Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683298A (en) * 1985-01-10 1987-07-28 British Columbia Research Council Process for the preparation of aminated polysaccharide derivatives
US5547936A (en) 1985-06-17 1996-08-20 La Jolla Cancer Research Foundation Inhibition of cell migration with synthetic peptides
ATE135584T1 (de) 1988-12-20 1996-04-15 Jolla Cancer Res Found Polypeptid-polymer-konjugate mit wundheilender wirkung
FR2644066B1 (fr) 1989-03-09 1994-05-13 Therapeutiques Substitutives Compositions stabilisees comprenant des fgfs, leur procede d'obtention et leurs applications therapeutiques, chirurgicales et cosmetologiques
US5693625A (en) 1989-03-09 1997-12-02 Therapeutiques Substitutives Method of regenerating cells and tissues using functionalized dextrans
US5342830A (en) 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
WO1992012175A1 (en) 1991-01-14 1992-07-23 New York University Cytokine-induced protein, tsg-6, dna coding therefor and uses thereof
JP2901787B2 (ja) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
FR2718023B1 (fr) 1994-03-30 1996-08-14 Paris Val Marne Universite Médicament et composition pharmaceutique pour le traitement de lésions du tractus digestif.
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
CA2299687C (en) 1997-08-04 2009-10-27 Bio Syntech Ltd. Temperature-controlled ph-dependant formation of ionic polysaccharide gels
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
KR20010032336A (ko) 1997-11-21 2001-04-16 브랑디 빠스깔 클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도
US20050208114A1 (en) 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
US7691829B2 (en) 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
JP3103531B2 (ja) 1998-09-30 2000-10-30 延也 柳内 ヒト尿由来細胞接着糖蛋白質及びその製造方法
US6822071B1 (en) 1998-11-12 2004-11-23 The Regents Of The University Of California Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
US6703491B1 (en) 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
US20110214206A1 (en) 1999-05-06 2011-09-01 La Rosa Thomas J Nucleic acid molecules and other molecules associated with plants
FR2794976B1 (fr) 1999-06-16 2004-05-07 Solutions Compositions pharmaceutiques a action cicatrisante ou anti-complementaire comprenant un derive de dextrane
JP4786095B2 (ja) 1999-09-15 2011-10-05 ユークリッド システムズ コーポレイション 角膜矯正レンズ装着中または装着後の角膜組織を安定化するための組成物
FR2799465B1 (fr) 1999-10-12 2004-02-13 Centre Nat Rech Scient Peptides ayant une activite de stimulation de la reponse immunitaire et de regeneration tissulaire
DE60003459T2 (de) 1999-12-09 2004-05-06 Biosyntech Canada Inc., Laval Mineral-polymer hybrid-zusammensetzung
US20030158302A1 (en) 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
AU2001288392A1 (en) 2000-08-30 2002-03-13 University Of Delaware Delivery system for heparin-binding growth factors
US7803905B2 (en) 2000-08-31 2010-09-28 University Of Delaware Bioactive peptide for cell adhesion
WO2002028441A2 (en) * 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
EP1335687B1 (en) 2000-11-15 2007-01-10 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
WO2003029401A2 (en) 2001-07-13 2003-04-10 Advanced Research And Technology Institute Peptidoglycan recognition protein encoding nucleic acids and methods of use thereof
AU2002323217B2 (en) * 2001-08-15 2008-04-10 Brown University Research Foundation Treatment of muscular dystrophies and related disorders
ES2357889T3 (es) 2001-11-15 2011-05-03 Piramal Healthcare (Canada) Limited Composición y método para reticular o modificar homogéneamente quitosano en condiciones neutras.
US20050108791A1 (en) 2001-12-04 2005-05-19 Edgerton Michael D. Transgenic plants with improved phenotypes
US20090100536A1 (en) 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
US20090158452A1 (en) 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
US20030220253A1 (en) * 2002-03-08 2003-11-27 Lasser Gerald W. Inhibitors for use in hemostasis
US7666852B2 (en) 2002-04-22 2010-02-23 Agenta Biotechnologies, Inc. Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
US7862831B2 (en) 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
WO2004033631A2 (en) 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
US20050069572A1 (en) 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
FR2846659B1 (fr) 2002-10-30 2005-02-18 Centre Nat Rech Scient Fragments peptidiques du facteur harp inhibant l'angiogenese
US20040127416A1 (en) 2002-11-15 2004-07-01 Massia Stephen P. Therapeutic bioconjugates
US8404681B2 (en) 2003-03-24 2013-03-26 Luitpold Pharmaceuticals, Inc. Xanthones, thioxanthones and acridinones as DNA-PK inhibitors
US8198020B2 (en) 2003-08-22 2012-06-12 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
EA010945B1 (ru) 2003-10-28 2008-12-30 Орган Тиссю Реженерасьон Репарасьон Рамплясман - Отр3 Применение биосовместимого полимера для изготовления медицинского устройства
FR2861308A1 (fr) 2003-10-28 2005-04-29 Organes Tissus Regeneration Re Utilisation de polymeres biocompatibles pour la preparation d'une composition pharmaceutique, dermatologique ou cosmetique destinee a la prevention, au soulagement ou au traitement des genes, desagrements et douleurs
CA2549883A1 (en) 2003-12-15 2005-06-23 Technion Research & Development Foundation Ltd. Therapeutic drug-eluting endoluminal covering
DK1722834T3 (da) 2003-12-22 2012-10-22 Regentis Biomaterials Ltd Matrix, som omfatter naturligt forekommende tværbundet proteinskelet
US7842667B2 (en) 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
US7709439B2 (en) 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
US20060041961A1 (en) 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
JP2008503205A (ja) 2004-05-31 2008-02-07 ナショナル ユニヴァーシティ オブ シンガポール デコリンロイシンリッチリピート由来のペプチドおよびその使用
US20060075522A1 (en) 2004-07-31 2006-04-06 Jaclyn Cleveland Genes and uses for plant improvement
WO2006036681A2 (en) 2004-09-22 2006-04-06 Cartilix, Inc. Cartilage filling device
JP5042025B2 (ja) 2004-09-29 2012-10-03 ナショナル ユニヴァーシティー オブ シンガポール 複合物、複合物の製造方法、およびその使用方法
US20060241022A1 (en) 2004-10-06 2006-10-26 Bowen Benjamin P Selectin targeting bioconjugates
WO2006047758A1 (en) 2004-10-27 2006-05-04 Massachusetts Institute Of Technology Novel technique to fabricate molded structures having a patterned porosity
US8283414B2 (en) 2004-11-23 2012-10-09 The Johns Hopkins University Compositions comprising modified collagen and uses therefor
WO2006089119A2 (en) 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
WO2006089167A1 (en) 2005-02-18 2006-08-24 Cartilix, Inc. Glucosamine materials
KR20070108555A (ko) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 혈관신생 헤파린 결합 펩티드 양친매성 화합물
GB2424223C (en) 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
US8431226B2 (en) 2005-03-30 2013-04-30 Biomet Manufacturing Corp. Coated medical device
US7737131B2 (en) 2005-03-31 2010-06-15 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US7732427B2 (en) 2005-03-31 2010-06-08 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US8338390B2 (en) 2005-03-31 2012-12-25 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US8367639B2 (en) 2005-03-31 2013-02-05 University Of Delaware Hydrogels with covalent and noncovalent crosslinks
US8415325B2 (en) 2005-03-31 2013-04-09 University Of Delaware Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels
EP1882392A4 (en) 2005-05-10 2009-07-01 Monsanto Technology Llc GENES AND THEIR USES FOR PLANT IMPROVEMENTS
EP1896386B1 (en) 2005-06-08 2012-09-05 Cangene Corporation Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
US20080069774A1 (en) 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
EP1996115B1 (en) 2006-03-07 2014-11-26 Axle International Bioactive scaffold for therapeutic and adhesion prevention applications
US20070212385A1 (en) 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
US20070260054A1 (en) 2006-03-15 2007-11-08 Surmodics, Inc. Hydrophobic derivatives of natural biodegradable polysaccharides and uses thereof
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
US20090162436A1 (en) 2006-06-14 2009-06-25 Carson Daniel D Compositions and methods for repair of tissues
EP2468300B1 (en) 2006-09-26 2017-12-20 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US8114835B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US20100222546A1 (en) 2006-11-28 2010-09-02 David Crich Methods for the preparation of functionalized peptides, proteins and carbohydrates and their conjugates
US20080295196A1 (en) 2006-12-06 2008-11-27 Abad Mark S Genes and uses for plant improvement
US8188220B2 (en) 2006-12-06 2012-05-29 Sanford-Burnham Medical Research Institute Methods and compositions related to targeting wounds, regenerating tissue, and tumors
US20080293640A1 (en) 2007-01-10 2008-11-27 Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of Polypeptide inhibitors of HSP27 kinase and uses therefor
WO2008126092A2 (en) 2007-04-16 2008-10-23 Regentis Biomaterials Ltd. Compositions and methods for scaffold formation
WO2008146956A1 (en) 2007-05-06 2008-12-04 Byoung-Hyun Min Therapeutic composite for cartilage disorder using extracellular matrix (ecm) scaffold
WO2008152639A2 (en) 2007-06-12 2008-12-18 Bypass, Inc. Pressure pulse actuating device for delivery systems
US20090075281A1 (en) 2007-07-10 2009-03-19 Regents Of The University Of California Mtbe genes
WO2009042514A1 (en) 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
US20100210509A1 (en) 2007-10-09 2010-08-19 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
WO2009099580A2 (en) 2008-02-05 2009-08-13 Monsanto Technology, Llc Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
HUE044239T2 (hu) 2008-03-27 2019-10-28 Purdue Research Foundation Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik
JP5758797B2 (ja) 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
US20100004196A1 (en) 2008-06-17 2010-01-07 Hopitaux Universitaires De Geneve Heparan sulfate proteoglycan composition and use thereof
WO2010011857A2 (en) 2008-07-23 2010-01-28 The Johns Hopkins University Parenteral administration of a glucosamine
WO2010019769A1 (en) 2008-08-15 2010-02-18 The Trustees Of The University Of Pennsylvania Cross-linked polymer network formed by sequential cross-linking
CN102216460A (zh) 2008-09-17 2011-10-12 希尔雷斯股份有限公司 生物量增加的转基因植物
FR2936247B1 (fr) 2008-09-24 2010-10-22 Ct Hospitalier Universitaire De Dijon Proteines recombinantes a activite hemostatique capables d'induire l'agregation plaquettaire.
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
EP2358758B1 (de) 2008-11-28 2012-09-05 Zetascience GmbH Bioaktives hydrogel
KR101062068B1 (ko) 2008-12-01 2011-09-02 포항공과대학교 산학협력단 유착방지용 조성물
IL195764A0 (en) 2008-12-07 2009-11-18 Technion Res & Dev Foundation Compositions and methods for drug delivery
US9012723B2 (en) 2009-01-16 2015-04-21 Monsanto Technology Llc Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits
FR2943249B1 (fr) * 2009-03-18 2011-08-12 Genethon Utilisation de la decorine pour augmenter la masse musculaire
CA2757444A1 (en) 2009-03-30 2010-10-14 Prometheus Laboratories Inc. Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis
US20110182862A1 (en) 2009-04-03 2011-07-28 Green Wayne A Endophytic fungus and uses therefor
EP2419116A1 (en) 2009-04-13 2012-02-22 North Western University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
FI20095452A0 (fi) 2009-04-23 2009-04-23 Suomen Punainen Risti Veripalv Uudet haaraiset sokerianalyysit
WO2010129547A1 (en) 2009-05-04 2010-11-11 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
GB0909671D0 (en) 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
WO2011057286A1 (en) 2009-11-09 2011-05-12 Drexel University Compositions and methods for treating a disorder or defect in soft tissue
WO2011069046A1 (en) 2009-12-04 2011-06-09 Euclid Systems Corporation Composition and methods for the prevention and treatment of macular degeneration, diabetic retinopathy, and diabetic macular edema
CN106039401A (zh) 2009-12-16 2016-10-26 瑞吉恩提斯生物材料有限公司 由聚合物‑蛋白质结合物形成的支架,产生该支架的方法及其用途
WO2011094149A1 (en) 2010-01-26 2011-08-04 University Of Utah Research Foundation Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
EP3569241A1 (en) 2010-02-26 2019-11-20 Vascular Biosciences, Inc. Car peptide for homing, diagnosis & targeted therapy for pulmonary and fibrotic disorders
WO2011163492A1 (en) 2010-06-23 2011-12-29 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for use in vascular intervention
US9173919B2 (en) 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
US20130101628A1 (en) 2011-04-29 2013-04-25 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9217016B2 (en) 2011-05-24 2015-12-22 Symic Ip, Llc Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use
EP2804586A4 (en) 2012-01-19 2016-03-16 Univ Johns Hopkins BIOMATERIALS CONTAINING HYALURONIC ACID BINDING PEPTIDES AND BIFUNCTIONAL BIOPOLYMERMOLUCKS FOR HYALURONIC ACIDIC TREATMENT AND TISSUE RENEWAL APPLICATIONS
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
US9827321B2 (en) 2012-08-14 2017-11-28 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
WO2014038866A1 (ko) 2012-09-05 2014-03-13 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
DE102012108560B4 (de) 2012-09-13 2018-12-20 Leibniz-Institut Für Polymerforschung Dresden E.V. Nichtkovalente selbstorganisierende Hydrogelmatrix für biotechnologische Anwendungen
WO2014063102A1 (en) 2012-10-19 2014-04-24 Cornell University Biomimetic boundary lubricants for articular cartilage
EP2915001A4 (en) 2012-11-01 2016-05-04 Univ Johns Hopkins CONTACT LENS SURFACE MODIFICATION WITH A HYALURONIC ACID BINDING PEPTIDE FOR THE ACCUMULATION AND STORAGE OF HYALURONIC ACID
KR20150095684A (ko) 2012-12-18 2015-08-21 노파르티스 아게 히알루로난에 결합하는 펩티드 태그를 이용하는 조성물 및 방법
EP2970509B1 (en) 2013-03-15 2020-05-13 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
JP6226305B2 (ja) 2013-04-16 2017-11-08 パナソニックIpマネジメント株式会社 電力変換装置、電力変換方法、モータシステム
WO2015022326A1 (en) 2013-08-12 2015-02-19 Xiber Science Gmbh Peptides as active agents for treating primary graft dysfunction
DE102013113156A1 (de) 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
KR20170016857A (ko) 2014-05-12 2017-02-14 퍼듀 리서치 파운데이션 셀렉틴 및 icam/vcam 펩티드 리간드 접합체
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
WO2016161333A2 (en) 2015-04-01 2016-10-06 Purdue Research Foundation Compositions comprising bioconjugates
MX2017013196A (es) 2015-04-17 2018-06-19 Symic Ip Llc Bioconjugados y usos de los mismos.
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate

Also Published As

Publication number Publication date
PT2280720T (pt) 2019-05-17
EP2280720A4 (en) 2013-01-09
HUE044239T2 (hu) 2019-10-28
WO2009120995A3 (en) 2010-01-28
JP5740301B2 (ja) 2015-06-24
EP2280720A2 (en) 2011-02-09
US10689425B2 (en) 2020-06-23
AU2017268544A1 (en) 2017-12-21
US20170275345A1 (en) 2017-09-28
US20110020298A1 (en) 2011-01-27
PL2280720T3 (pl) 2019-07-31
SI2280720T1 (sl) 2019-06-28
AU2015230796A1 (en) 2015-10-15
US8846003B2 (en) 2014-09-30
AU2020201042A1 (en) 2020-03-05
WO2009120995A2 (en) 2009-10-01
CA2719254A1 (en) 2009-10-01
AU2015230796B2 (en) 2017-08-31
JP2015134768A (ja) 2015-07-27
AU2009228140B2 (en) 2015-07-02
CA2719254C (en) 2019-04-30
DK2280720T3 (en) 2019-06-11
US20150031619A1 (en) 2015-01-29
JP2011515499A (ja) 2011-05-19
HRP20190691T1 (hr) 2019-07-12
EP2280720B1 (en) 2019-01-16
AU2009228140A1 (en) 2009-10-01
LT2280720T (lt) 2019-07-25
US9512192B2 (en) 2016-12-06
CY1121954T1 (el) 2020-10-14
JP6049773B2 (ja) 2016-12-27
US20160244495A1 (en) 2016-08-25

Similar Documents

Publication Publication Date Title
US10689425B2 (en) Collagen-binding synthetic peptidoglycans, preparation, and methods of use
ES2742218T3 (es) Peptidoglicanos sintéticos que se enlazan al colágeno destinados a ser utilizados en operaciones vasculares
ES2423798T3 (es) Hidrogeles de PEG disolubles sensibles a estímulos biofuncionalizados
US20170283458A1 (en) Collagen-binding synthetic peptidoglycans for wound healing
ES2709125T3 (es) Péptidos autoensamblantes modificados
DK2513294T3 (en) SKELETS FOR POLYMER-PROTEIN CONJUGATES, PROCEDURES FOR GENERATION THEREOF AND APPLICATIONS THEREOF
US20170189582A1 (en) Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof
KR102006036B1 (ko) 히알루론산-결합 합성 펩티도글리칸 및 이의 제조 및 이용 방법
US10828370B2 (en) Selectin and ICAM/VCAM peptide ligand conjugates
WO2012158169A1 (en) Methods and compositions for tissue repair
Kumari et al. Antifibrotic properties of hyaluronic acid crosslinked polyisocyanide hydrogels
US20110287068A1 (en) Fibrin and fibrinogen matrices and uses of same
Lin Development of Targeted Pro-angiogenic Therapies for Ischemic Diabetic Foot Ulcer Repair