ES2707362T3 - 6-nitro-2,3-dihidroimidazo [2,1-b] oxazoles y un procedimiento de preparación de los mismos - Google Patents
6-nitro-2,3-dihidroimidazo [2,1-b] oxazoles y un procedimiento de preparación de los mismos Download PDFInfo
- Publication number
- ES2707362T3 ES2707362T3 ES14725544T ES14725544T ES2707362T3 ES 2707362 T3 ES2707362 T3 ES 2707362T3 ES 14725544 T ES14725544 T ES 14725544T ES 14725544 T ES14725544 T ES 14725544T ES 2707362 T3 ES2707362 T3 ES 2707362T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- oxazole
- phenoxymethyl
- dihydro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C[C@](COc(cc1)ccc1N(C1)N=NC1c(cc1)ccc1F)(*1)OC(N2)N1C=C2[N+]([O-])=O Chemical compound C[C@](COc(cc1)ccc1N(C1)N=NC1c(cc1)ccc1F)(*1)OC(N2)N1C=C2[N+]([O-])=O 0.000 description 4
- FKKBVJOUNIBUOD-NRUKRLKBSA-N CCC(CC1)=CC=C1C1=CN(C(C)(CC2)C=CC2(C)OC[C@]2(C)Oc3nc([N+]([O-])=O)c[n]3C2)[N-][NH+]1C Chemical compound CCC(CC1)=CC=C1C1=CN(C(C)(CC2)C=CC2(C)OC[C@]2(C)Oc3nc([N+]([O-])=O)c[n]3C2)[N-][NH+]1C FKKBVJOUNIBUOD-NRUKRLKBSA-N 0.000 description 1
- DMVWLRROZLFTFF-UHFFFAOYSA-N [O-][N+](c1c[n](CC2(COc3cccc(CC4N=NC(c(cc5)ccc5OC(F)(F)F)=CCC4)c3)CC2)c(O)n1)=O Chemical compound [O-][N+](c1c[n](CC2(COc3cccc(CC4N=NC(c(cc5)ccc5OC(F)(F)F)=CCC4)c3)CC2)c(O)n1)=O DMVWLRROZLFTFF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2954DE2013 IN2013DE02954A (cg-RX-API-DMAC7.html) | 2013-10-04 | 2014-03-31 | |
| PCT/IN2014/000202 WO2015049693A1 (en) | 2013-10-04 | 2014-03-31 | 6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2707362T3 true ES2707362T3 (es) | 2019-04-03 |
Family
ID=50771310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14725544T Active ES2707362T3 (es) | 2013-10-04 | 2014-03-31 | 6-nitro-2,3-dihidroimidazo [2,1-b] oxazoles y un procedimiento de preparación de los mismos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9845330B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3052503B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6532457B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2707362T3 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2013DE02954A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI654192B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015049693A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6467042B2 (ja) * | 2014-10-21 | 2019-02-06 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 抗マイコバクテリア剤としての置換１，２，３−トリアゾール−１−イル−メチル−２，３−ジヒドロ−２−メチル−６−ニトロイミダゾ［２，１−ｂ］オキサゾールとその調製方法 |
| CN108059623B (zh) * | 2016-11-07 | 2021-07-13 | 浙江省化工研究院有限公司 | 一类含取代芳基联异噁唑芳基脒类化合物、其制备方法及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR041198A1 (es) | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
| JP4761756B2 (ja) * | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物 |
| SI1678185T1 (sl) * | 2003-10-31 | 2009-02-28 | Otsuka Pharma Co Ltd | Spojine 2,3-dihidro-6-nitroimidazo (2,1-b) oksazol za zdravljenje tuberkuloze |
| JP4787529B2 (ja) * | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| US7049876B2 (en) | 2004-10-25 | 2006-05-23 | Delphi Technologies, Inc. | Level shift circuits and related methods |
| PL1906926T3 (pl) | 2005-07-28 | 2011-04-29 | Otsuka Pharma Co Ltd | Kompozycja farmaceutyczna zawierająca pochodne 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu |
| CN101965353B (zh) * | 2008-03-26 | 2014-12-17 | 丹诺医药(苏州）有限公司 | 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类 |
-
2014
- 2014-03-31 IN IN2954DE2013 patent/IN2013DE02954A/en unknown
- 2014-03-31 WO PCT/IN2014/000202 patent/WO2015049693A1/en not_active Ceased
- 2014-03-31 ES ES14725544T patent/ES2707362T3/es active Active
- 2014-03-31 JP JP2016520053A patent/JP6532457B2/ja not_active Expired - Fee Related
- 2014-03-31 EP EP14725544.2A patent/EP3052503B1/en active Active
- 2014-03-31 US US15/027,137 patent/US9845330B2/en not_active Expired - Fee Related
- 2014-06-13 TW TW103120596A patent/TWI654192B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP3052503A1 (en) | 2016-08-10 |
| JP2016531898A (ja) | 2016-10-13 |
| IN2013DE02954A (cg-RX-API-DMAC7.html) | 2015-04-10 |
| EP3052503B1 (en) | 2018-10-24 |
| TWI654192B (zh) | 2019-03-21 |
| WO2015049693A1 (en) | 2015-04-09 |
| US20160244462A1 (en) | 2016-08-25 |
| US9845330B2 (en) | 2017-12-19 |
| TW201514184A (zh) | 2015-04-16 |
| JP6532457B2 (ja) | 2019-06-19 |
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