ES2704014T3 - Dispositivos médicos y métodos que incluyen mezclas de polímeros biodegradables - Google Patents
Dispositivos médicos y métodos que incluyen mezclas de polímeros biodegradables Download PDFInfo
- Publication number
- ES2704014T3 ES2704014T3 ES09791121T ES09791121T ES2704014T3 ES 2704014 T3 ES2704014 T3 ES 2704014T3 ES 09791121 T ES09791121 T ES 09791121T ES 09791121 T ES09791121 T ES 09791121T ES 2704014 T3 ES2704014 T3 ES 2704014T3
- Authority
- ES
- Spain
- Prior art keywords
- polymer
- phase
- modulus
- axis
- biodegradable polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002988 biodegradable polymer Polymers 0.000 title claims abstract description 106
- 239000004621 biodegradable polymer Substances 0.000 title claims abstract description 105
- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 238000000034 method Methods 0.000 title claims abstract description 47
- 229920002959 polymer blend Polymers 0.000 claims abstract description 117
- 238000002156 mixing Methods 0.000 claims abstract description 49
- 229920000642 polymer Polymers 0.000 claims abstract description 32
- 230000009477 glass transition Effects 0.000 claims abstract description 16
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 116
- 229920001577 copolymer Polymers 0.000 claims description 27
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 24
- 229920001610 polycaprolactone Polymers 0.000 claims description 21
- 239000004632 polycaprolactone Substances 0.000 claims description 21
- 239000002904 solvent Substances 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 19
- 239000007787 solid Substances 0.000 claims description 18
- 229920001519 homopolymer Polymers 0.000 claims description 16
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 8
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims description 8
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 2
- 229920001306 poly(lactide-co-caprolactone) Polymers 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 84
- 238000012360 testing method Methods 0.000 description 29
- 230000015556 catabolic process Effects 0.000 description 28
- 238000006731 degradation reaction Methods 0.000 description 28
- 239000000463 material Substances 0.000 description 23
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 239000002245 particle Substances 0.000 description 7
- 238000009864 tensile test Methods 0.000 description 7
- 238000003917 TEM image Methods 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000010828 elution Methods 0.000 description 6
- 239000004626 polylactic acid Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 239000007850 fluorescent dye Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000000155 melt Substances 0.000 description 5
- -1 polytrimethylene carbonate Polymers 0.000 description 5
- 230000002787 reinforcement Effects 0.000 description 5
- 238000001215 fluorescent labelling Methods 0.000 description 4
- 238000001641 gel filtration chromatography Methods 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000005809 transesterification reaction Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000000071 blow moulding Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 238000004626 scanning electron microscopy Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000004627 transmission electron microscopy Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 238000004736 wide-angle X-ray diffraction Methods 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 238000000333 X-ray scattering Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920000402 bisphenol A polycarbonate polymer Polymers 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010622 cold drawing Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000010952 in-situ formation Methods 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005297 material degradation process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920006030 multiblock copolymer Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001448 refractive index detection Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000010512 thermal transition Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8670708P | 2008-08-06 | 2008-08-06 | |
| US12/534,264 US8129477B1 (en) | 2008-08-06 | 2009-08-03 | Medical devices and methods including blends of biodegradable polymers |
| PCT/US2009/052626 WO2010017153A2 (en) | 2008-08-06 | 2009-08-04 | Medical devices and methods including blends of biodegradable polymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2704014T3 true ES2704014T3 (es) | 2019-03-13 |
Family
ID=41340992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09791121T Active ES2704014T3 (es) | 2008-08-06 | 2009-08-04 | Dispositivos médicos y métodos que incluyen mezclas de polímeros biodegradables |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8129477B1 (enExample) |
| EP (1) | EP2318059B1 (enExample) |
| JP (1) | JP2011530331A (enExample) |
| CN (1) | CN102143766B (enExample) |
| ES (1) | ES2704014T3 (enExample) |
| WO (1) | WO2010017153A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8496865B2 (en) * | 2010-10-15 | 2013-07-30 | Abbott Cardiovascular Systems Inc. | Method to minimize chain scission and monomer generation in processing of poly(L-lactide) stent |
| US10940167B2 (en) | 2012-02-10 | 2021-03-09 | Cvdevices, Llc | Methods and uses of biological tissues for various stent and other medical applications |
| WO2014124356A2 (en) | 2013-02-11 | 2014-08-14 | Cook Medical Technologies Llc | Expandable support frame and medical device |
| WO2015034889A2 (en) | 2013-09-04 | 2015-03-12 | Zzyzx Polymers LLC | Methods for increasing throughput rates of solid-state extrusion devices |
| WO2015054595A1 (en) * | 2013-10-12 | 2015-04-16 | Zzyzx Polymers LLC | Fabricating drug delivery systems |
| US20230323115A1 (en) * | 2020-10-30 | 2023-10-12 | Toray Industries, Inc. | Polymer composition and molded article |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4844854A (en) | 1987-09-22 | 1989-07-04 | United States Surgical Corporation | Process for making a surgical device using two-phase compositions |
| US5252642A (en) | 1989-03-01 | 1993-10-12 | Biopak Technology, Ltd. | Degradable impact modified polyactic acid |
| US5641501A (en) | 1994-10-11 | 1997-06-24 | Ethicon, Inc. | Absorbable polymer blends |
| US5871468A (en) | 1996-04-24 | 1999-02-16 | Medtronic, Inc. | Medical catheter with a high pressure/low compliant balloon |
| US5756651A (en) * | 1996-07-17 | 1998-05-26 | Chronopol, Inc. | Impact modified polylactide |
| US6150493A (en) | 1997-06-12 | 2000-11-21 | General Electric Company | Process for the preparation of poly(ester-carbonate)s |
| DE19755966B4 (de) * | 1997-12-16 | 2004-08-05 | Urs J. Dr. Hänggi | Verwendung von Formulierungen von wasserfesten, biologisch abbaubaren Polymeren aus nachwachsenden Rohstoffen mit erhöhter Bindungsaffinität zur Herstellung von Trägern für Analysensysteme und Testsysteme aus diesen Formulierungen |
| GB9814609D0 (en) | 1998-07-07 | 1998-09-02 | Smith & Nephew | Polymers |
| US6400992B1 (en) | 1999-03-18 | 2002-06-04 | Medtronic, Inc. | Co-extruded, multi-lumen medical lead |
| US6573340B1 (en) * | 2000-08-23 | 2003-06-03 | Biotec Biologische Naturverpackungen Gmbh & Co. Kg | Biodegradable polymer films and sheets suitable for use as laminate coatings as well as wraps and other packaging materials |
| US6607548B2 (en) | 2001-05-17 | 2003-08-19 | Inion Ltd. | Resorbable polymer compositions |
| US6926903B2 (en) | 2001-12-04 | 2005-08-09 | Inion Ltd. | Resorbable polymer composition, implant and method of making implant |
| US20030105530A1 (en) | 2001-12-04 | 2003-06-05 | Inion Ltd. | Biodegradable implant and method for manufacturing one |
| GB0202233D0 (en) | 2002-01-31 | 2002-03-20 | Smith & Nephew | Bioresorbable polymers |
| GB0317192D0 (en) | 2003-07-19 | 2003-08-27 | Smith & Nephew | High strength bioresorbable co-polymers |
| US20050137360A1 (en) | 2003-12-19 | 2005-06-23 | General Electric Company | Clear polycarbonate polyester blend |
| US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
| US20060041102A1 (en) | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
| CA2619571A1 (en) | 2005-08-18 | 2007-02-22 | Smith & Nephew, Plc | High strength devices and composites |
| US20090274742A1 (en) | 2005-08-18 | 2009-11-05 | Brown Malcolm Nmi | Multimodal high strength devices and composites |
| WO2007066345A1 (en) | 2005-12-09 | 2007-06-14 | Council Of Scientific & Industrial Research | A melt transurethane process for the preparation of polyurethanes |
| WO2007092417A1 (en) * | 2006-02-07 | 2007-08-16 | Tepha, Inc. | Toughened polylactic acid polymers and copolymers |
| US20070203569A1 (en) * | 2006-02-24 | 2007-08-30 | Robert Burgermeister | Implantable device formed from polymer blends having modified molecular structures |
| GB0605885D0 (en) | 2006-03-24 | 2006-05-03 | Smith & Nephew | Composite Material |
| US7964210B2 (en) | 2006-03-31 | 2011-06-21 | Abbott Cardiovascular Systems Inc. | Degradable polymeric implantable medical devices with a continuous phase and discrete phase |
| CA2652753C (en) | 2006-05-12 | 2015-12-08 | Cordis Corporation | Balloon expandable bioabsorbable drug eluting stent |
| US20080033540A1 (en) | 2006-08-01 | 2008-02-07 | Yunbing Wang | Methods to prepare polymer blend implantable medical devices |
| US7923022B2 (en) | 2006-09-13 | 2011-04-12 | Advanced Cardiovascular Systems, Inc. | Degradable polymeric implantable medical devices with continuous phase and discrete phase |
| CN101205356A (zh) * | 2006-12-22 | 2008-06-25 | 深圳市奥贝尔科技有限公司 | 聚羟基烷酸酯及其共聚物与聚乳酸的共混改性 |
-
2009
- 2009-08-03 US US12/534,264 patent/US8129477B1/en active Active
- 2009-08-04 CN CN200980135834.0A patent/CN102143766B/zh active Active
- 2009-08-04 WO PCT/US2009/052626 patent/WO2010017153A2/en not_active Ceased
- 2009-08-04 JP JP2011522153A patent/JP2011530331A/ja active Pending
- 2009-08-04 ES ES09791121T patent/ES2704014T3/es active Active
- 2009-08-04 EP EP09791121.8A patent/EP2318059B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102143766A (zh) | 2011-08-03 |
| EP2318059A2 (en) | 2011-05-11 |
| WO2010017153A2 (en) | 2010-02-11 |
| US8129477B1 (en) | 2012-03-06 |
| JP2011530331A (ja) | 2011-12-22 |
| CN102143766B (zh) | 2014-04-23 |
| EP2318059B1 (en) | 2018-10-03 |
| WO2010017153A3 (en) | 2011-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kouhi et al. | Poly (ε-caprolactone) incorporated bioactive glass nanoparticles and simvastatin nanocomposite nanofibers: Preparation, characterization and in vitro drug release for bone regeneration applications | |
| Boland et al. | Electrospinning polydioxanone for biomedical applications | |
| ES2704014T3 (es) | Dispositivos médicos y métodos que incluyen mezclas de polímeros biodegradables | |
| Ramot et al. | Biocompatibility and safety of PLA and its copolymers | |
| Chen et al. | The effect of surface area on the degradation rate of nano-fibrous poly (L-lactic acid) foams | |
| ES2395112T3 (es) | Polímeros y copolímeros de ácido poliláctico endurecidos | |
| ES2685963T3 (es) | Bandas de microfibras de poli-4-hidroxibutirato y sus copolímeros producidas por hilado centrífugo | |
| Davachi et al. | Investigating thermal, mechanical and rheological properties of novel antibacterial hybrid nanocomposites based on PLLA/triclosan/nano-hydroxyapatite | |
| ES2734126T3 (es) | Composiciones biocerámicas reabsorbibles de poli-4-hidroxibutirato y copolímeros | |
| Sultana et al. | Composite synthetic scaffolds for tissue engineering and regenerative medicine | |
| Im et al. | In vitro and in vivo degradation behaviors of synthetic absorbable bicomponent monofilament suture prepared with poly (p-dioxanone) and its copolymer | |
| CN110072921A (zh) | 生物降解性高分子的多孔性微粒及包含其的高分子填充物 | |
| Nagahama et al. | Impacts of stereoregularity and stereocomplex formation on physicochemical, protein adsorption and cell adhesion behaviors of star-shaped 8-arms poly (ethylene glycol)–poly (lactide) block copolymer films | |
| Chitrattha et al. | Modifying poly (L-lactic acid) matrix film properties with high loaded poly (ethylene glycol) | |
| JP6739455B2 (ja) | 無水生体適合性複合材料 | |
| Narayanan et al. | Correlation of the stoichiometries of poly (ε-caprolactone) and α-cyclodextrin pseudorotaxanes with their solution rheology and the molecular orientation, crystallite size, and thermomechanical properties of their nanofibers | |
| Abdullah et al. | The Influence of In Vitro Degradation on the Properties of Polylactic Acid Electrospun Fiber Mats | |
| Penhasi et al. | High modulus thermoplastic segmented polyurethane/poly (L‐lactide) blends as potential candidates for structural implantable drug delivery systems: I. Structure‐properties relationship study | |
| Das et al. | Fabrication of stimuli-responsive polymers and their composites: Candidates for resorbable sutures | |
| JP5497483B2 (ja) | 繊維成形体およびその製造方法 | |
| Eesaee et al. | Miscibility, morphology, and crystallization kinetics of biodegradable poly (ε-caprolactone)/ascorbic acid blends | |
| Yang et al. | Bionic structure and blood compatibility of highly oriented homo-epitaxially crystallized poly (l-lactic acid) | |
| Sawalha et al. | Influence of polymer solution composition on the microstructure and thermal and mechanical characteristics of polycaprolactone films | |
| ES2504666B1 (es) | NUEVOS TERPOLÍMEROS ALEATORIOS A BASE DE D-LACTIDA, L-LACTIDA y E-CAPROLACTONA | |
| Amaral et al. | Chemical processing and physical-chemical and mechanical characterizations of poly (L-co-D, L lactic acid)/polyethylene glycol mixtures for application as a biomedical device |