ES2703052T3 - Aislamiento de mutantes potenciadores del tráfico de proteína de entrega de fármacos - Google Patents

Aislamiento de mutantes potenciadores del tráfico de proteína de entrega de fármacos Download PDF

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Publication number
ES2703052T3
ES2703052T3 ES13826083T ES13826083T ES2703052T3 ES 2703052 T3 ES2703052 T3 ES 2703052T3 ES 13826083 T ES13826083 T ES 13826083T ES 13826083 T ES13826083 T ES 13826083T ES 2703052 T3 ES2703052 T3 ES 2703052T3
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polypeptide
seq
penton
cells
phage
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Spanish (es)
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Lali K Medina-Kauwe
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Cedars Sinai Medical Center
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Cedars Sinai Medical Center
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1058Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07KPEPTIDES
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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • CCHEMISTRY; METALLURGY
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
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  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES13826083T 2012-08-03 2013-08-02 Aislamiento de mutantes potenciadores del tráfico de proteína de entrega de fármacos Active ES2703052T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261679306P 2012-08-03 2012-08-03
PCT/US2013/053493 WO2014022811A1 (en) 2012-08-03 2013-08-02 Isolating traffic-enhancing mutants of drug delivery protein

Publications (1)

Publication Number Publication Date
ES2703052T3 true ES2703052T3 (es) 2019-03-06

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ES13826083T Active ES2703052T3 (es) 2012-08-03 2013-08-02 Aislamiento de mutantes potenciadores del tráfico de proteína de entrega de fármacos

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Country Link
US (2) US10036009B2 (cg-RX-API-DMAC7.html)
EP (1) EP2880160B1 (cg-RX-API-DMAC7.html)
JP (2) JP6618360B2 (cg-RX-API-DMAC7.html)
KR (1) KR102115630B1 (cg-RX-API-DMAC7.html)
CN (1) CN104619839A (cg-RX-API-DMAC7.html)
AU (2) AU2013296218B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015002004A2 (cg-RX-API-DMAC7.html)
CA (1) CA2881582A1 (cg-RX-API-DMAC7.html)
DK (1) DK2880160T3 (cg-RX-API-DMAC7.html)
ES (1) ES2703052T3 (cg-RX-API-DMAC7.html)
IL (1) IL236955A0 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01196A (cg-RX-API-DMAC7.html)
MX (1) MX366347B (cg-RX-API-DMAC7.html)
PL (1) PL2880160T3 (cg-RX-API-DMAC7.html)
PT (1) PT2880160T (cg-RX-API-DMAC7.html)
RU (1) RU2015105052A (cg-RX-API-DMAC7.html)
WO (1) WO2014022811A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201500739B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US9078927B2 (en) 2007-07-06 2015-07-14 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells
WO2010085665A2 (en) 2009-01-23 2010-07-29 Cedars-Sinai Medical Center Targeted delivery system
EP2880160B1 (en) * 2012-08-03 2018-09-19 Cedars-Sinai Medical Center Isolating traffic-enhancing mutants of drug delivery protein
US9757386B2 (en) 2013-05-08 2017-09-12 Cedars-Sinai Medical Center Targeting corroles for tumor toxicity and MRI
CN106413738B (zh) 2014-01-17 2020-12-29 席德-西奈医疗中心 受体靶向构造物和其使用
RU2692104C2 (ru) 2014-04-04 2019-06-21 Сидарс-Синай Медикал Сентр Адресное воздействие на устойчивый к трастузумабу her2+ рак молочной железы посредством her3-нацеленных наночастиц

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US6287792B1 (en) 1991-06-17 2001-09-11 The Regents Of The University Of California Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
GB9223084D0 (en) 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
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US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
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CN106413738B (zh) * 2014-01-17 2020-12-29 席德-西奈医疗中心 受体靶向构造物和其使用
RU2692104C2 (ru) * 2014-04-04 2019-06-21 Сидарс-Синай Медикал Сентр Адресное воздействие на устойчивый к трастузумабу her2+ рак молочной железы посредством her3-нацеленных наночастиц
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IN2015DN01196A (cg-RX-API-DMAC7.html) 2015-06-26
JP2015527343A (ja) 2015-09-17
JP6618360B2 (ja) 2019-12-11
MX2015001366A (es) 2015-08-13
KR102115630B1 (ko) 2020-05-27
AU2019204815A1 (en) 2019-07-25
US20150240231A1 (en) 2015-08-27
AU2013296218A1 (en) 2015-02-19
US20180298376A1 (en) 2018-10-18
JP2020002138A (ja) 2020-01-09
IL236955A0 (en) 2015-03-31
US10752893B2 (en) 2020-08-25
US10036009B2 (en) 2018-07-31
PL2880160T3 (pl) 2019-03-29
BR112015002004A2 (pt) 2017-07-04
AU2013296218B2 (en) 2019-07-18
PT2880160T (pt) 2018-12-17
CA2881582A1 (en) 2014-02-06
CN104619839A (zh) 2015-05-13
WO2014022811A1 (en) 2014-02-06
MX366347B (es) 2019-07-05
EP2880160B1 (en) 2018-09-19
EP2880160A1 (en) 2015-06-10
DK2880160T3 (en) 2019-01-14
EP2880160A4 (en) 2016-04-20
ZA201500739B (en) 2018-07-25
KR20150038543A (ko) 2015-04-08
RU2015105052A (ru) 2016-09-27

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