ES269962A1 - Procedimiento de obtenciën de nuevos derivados del acido lisergico y del acido dihidrolisergico - Google Patents
Procedimiento de obtenciën de nuevos derivados del acido lisergico y del acido dihidrolisergicoInfo
- Publication number
- ES269962A1 ES269962A1 ES0269962A ES269962A ES269962A1 ES 269962 A1 ES269962 A1 ES 269962A1 ES 0269962 A ES0269962 A ES 0269962A ES 269962 A ES269962 A ES 269962A ES 269962 A1 ES269962 A1 ES 269962A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- lysergic
- alkali metal
- amide
- dihydrolysergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- ZAGRKAFMISFKIO-QMTHXVAHSA-N lysergic acid Chemical class C1=CC(C2=C[C@H](CN([C@@H]2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-QMTHXVAHSA-N 0.000 title abstract 2
- -1 hydroxyalkyl radicals Chemical class 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001376 precipitating effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WGZBEDCLEXJQGW-XHDPSFHLSA-N (6aR,9S)-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxylic acid Chemical compound CN1C=C2C[C@H]3N(C[C@@H](C(O)=O)C=C3C=3C=CC=C1C32)C WGZBEDCLEXJQGW-XHDPSFHLSA-N 0.000 abstract 1
- WGZBEDCLEXJQGW-IAQYHMDHSA-N (6ar,9r)-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxylic acid Chemical compound C1=CC(C2=C[C@H](CN([C@@H]2C2)C)C(O)=O)=C3C2=CN(C)C3=C1 WGZBEDCLEXJQGW-IAQYHMDHSA-N 0.000 abstract 1
- ZAGRKAFMISFKIO-IINYFYTJSA-N (6ar,9s)-7-methyl-6,6a,8,9-tetrahydro-4h-indolo[4,3-fg]quinoline-9-carboxylic acid Chemical class C1=CC(C2=C[C@@H](CN([C@@H]2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-IINYFYTJSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- ZAGRKAFMISFKIO-UHFFFAOYSA-N Isolysergic acid Natural products C1=CC(C2=CC(CN(C2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960003133 ergot alkaloid Drugs 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000010575 fractional recrystallization Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008239 natural water Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH939760A CH386440A (de) | 1960-08-19 | 1960-08-19 | Verfahren zur Herstellung von neuen Lysergsäuren |
| CH1197460 | 1960-10-26 | ||
| CH96761A CH390930A (de) | 1961-01-27 | 1961-01-27 | Verfahren zur Herstellung von heterocyclischen Verbindungen |
| CH189161 | 1961-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES269962A1 true ES269962A1 (es) | 1962-04-16 |
Family
ID=27428042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269962A Expired ES269962A1 (es) | 1960-08-19 | 1961-08-17 | Procedimiento de obtenciën de nuevos derivados del acido lisergico y del acido dihidrolisergico |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1161566B (OSRAM) |
| ES (1) | ES269962A1 (OSRAM) |
| GB (1) | GB988001A (OSRAM) |
| SE (1) | SE218990C1 (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005082902A1 (en) * | 2004-02-20 | 2005-09-09 | Ivax Pharmaceuticals S.R.O. | Process for the manufacture of lysergic acid |
-
1961
- 1961-08-09 GB GB28785/61A patent/GB988001A/en not_active Expired
- 1961-08-17 ES ES0269962A patent/ES269962A1/es not_active Expired
- 1961-08-17 DE DE1961S0075337 patent/DE1161566B/de active Pending
- 1961-08-18 SE SE835961A patent/SE218990C1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB988001A (en) | 1965-03-31 |
| DE1161566B (de) | 1964-01-23 |
| SE218990C1 (OSRAM) | 1968-02-20 |
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