ES2672590T3 - Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada - Google Patents
Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada Download PDFInfo
- Publication number
- ES2672590T3 ES2672590T3 ES10827483.8T ES10827483T ES2672590T3 ES 2672590 T3 ES2672590 T3 ES 2672590T3 ES 10827483 T ES10827483 T ES 10827483T ES 2672590 T3 ES2672590 T3 ES 2672590T3
- Authority
- ES
- Spain
- Prior art keywords
- bone graft
- fibers
- graft material
- bone
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000463 material Substances 0.000 title claims abstract description 240
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 220
- 230000000975 bioactive effect Effects 0.000 title description 15
- 239000000835 fiber Substances 0.000 claims abstract description 151
- 239000005313 bioactive glass Substances 0.000 claims abstract description 63
- 239000002245 particle Substances 0.000 claims abstract description 59
- 239000011148 porous material Substances 0.000 claims abstract description 55
- 239000011159 matrix material Substances 0.000 claims abstract description 39
- 238000009826 distribution Methods 0.000 claims abstract description 15
- 230000033001 locomotion Effects 0.000 claims abstract description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 19
- 239000001506 calcium phosphate Substances 0.000 claims description 18
- 230000000845 anti-microbial effect Effects 0.000 claims description 13
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 12
- 102000008186 Collagen Human genes 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 11
- 235000011010 calcium phosphates Nutrition 0.000 claims description 11
- 229920001436 collagen Polymers 0.000 claims description 11
- 239000000654 additive Substances 0.000 claims description 9
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 235000011132 calcium sulphate Nutrition 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000004332 silver Substances 0.000 claims description 7
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 7
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 7
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000003443 antiviral agent Substances 0.000 claims description 4
- 229940121357 antivirals Drugs 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 229910052712 strontium Inorganic materials 0.000 claims description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000002513 implantation Methods 0.000 claims description 3
- 235000015097 nutrients Nutrition 0.000 claims description 3
- 239000003605 opacifier Substances 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910044991 metal oxide Inorganic materials 0.000 claims description 2
- 150000004706 metal oxides Chemical class 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 239000007943 implant Substances 0.000 description 36
- 239000000203 mixture Substances 0.000 description 31
- 230000035876 healing Effects 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 17
- 239000011521 glass Substances 0.000 description 17
- 230000008468 bone growth Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 239000012530 fluid Substances 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 238000010276 construction Methods 0.000 description 8
- 230000007547 defect Effects 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 239000011236 particulate material Substances 0.000 description 8
- 235000009161 Espostoa lanata Nutrition 0.000 description 7
- 240000001624 Espostoa lanata Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 210000001185 bone marrow Anatomy 0.000 description 6
- 239000006260 foam Substances 0.000 description 6
- 230000011164 ossification Effects 0.000 description 6
- 210000000963 osteoblast Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 230000000278 osteoconductive effect Effects 0.000 description 5
- 230000035790 physiological processes and functions Effects 0.000 description 5
- 238000007634 remodeling Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 229910052681 coesite Inorganic materials 0.000 description 4
- 229910052906 cristobalite Inorganic materials 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229910052682 stishovite Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 229920002994 synthetic fiber Polymers 0.000 description 4
- 229910052905 tridymite Inorganic materials 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000010072 bone remodeling Effects 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000512 collagen gel Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000011152 fibreglass Substances 0.000 description 3
- -1 for example Substances 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 239000002121 nanofiber Substances 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000009772 tissue formation Effects 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000010256 bone deposition Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009103 reabsorption Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000012890 simulated body fluid Substances 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000004067 Osteocalcin Human genes 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000037176 bone building Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000014461 bone development Effects 0.000 description 1
- 230000037180 bone health Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 239000004566 building material Substances 0.000 description 1
- 239000004068 calcium phosphate ceramic Substances 0.000 description 1
- VAWSWDPVUFTPQO-UHFFFAOYSA-N calcium strontium Chemical compound [Ca].[Sr] VAWSWDPVUFTPQO-UHFFFAOYSA-N 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000005482 chemotactic factor Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007120 differential activation Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005315 distribution function Methods 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 239000002241 glass-ceramic Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000009442 healing mechanism Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 230000004820 osteoconduction Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 238000002459 porosimetry Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000001812 pycnometry Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Ceramic Engineering (AREA)
- Dispersion Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25628709P | 2009-10-29 | 2009-10-29 | |
| US256287P | 2009-10-29 | ||
| US38996410P | 2010-10-05 | 2010-10-05 | |
| US389964P | 2010-10-05 | ||
| PCT/US2010/054535 WO2011053719A1 (en) | 2009-10-29 | 2010-10-28 | Dynamic bioactive bone graft material having an engineered porosity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2672590T3 true ES2672590T3 (es) | 2018-06-15 |
Family
ID=43922548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10827483.8T Active ES2672590T3 (es) | 2009-10-29 | 2010-10-28 | Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada |
| ES18167603T Active ES2901457T3 (es) | 2009-10-29 | 2010-10-28 | Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18167603T Active ES2901457T3 (es) | 2009-10-29 | 2010-10-28 | Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20110144763A1 (enExample) |
| EP (2) | EP2493519B1 (enExample) |
| JP (1) | JP5792736B2 (enExample) |
| KR (1) | KR20120099058A (enExample) |
| CN (1) | CN102596271B (enExample) |
| AU (1) | AU2010313415B2 (enExample) |
| CA (1) | CA2779109A1 (enExample) |
| ES (2) | ES2672590T3 (enExample) |
| MX (1) | MX2012004917A (enExample) |
| WO (1) | WO2011053719A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20095084A0 (fi) | 2009-01-30 | 2009-01-30 | Pekka Vallittu | Komposiitti ja sen käyttö |
| EP2493425B1 (en) | 2009-10-29 | 2016-10-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material and methods for handling |
| CA2779109A1 (en) | 2009-10-29 | 2011-05-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material having an engineered porosity |
| KR101269127B1 (ko) * | 2011-10-18 | 2013-05-29 | 포항공과대학교 산학협력단 | 멤브레인형 인공 지지체 및 이의 제조 방법 |
| GB201122405D0 (en) * | 2011-12-23 | 2012-02-08 | Univ Aberdeen | Calcium phosphate material |
| US9045362B2 (en) | 2013-03-15 | 2015-06-02 | Mosci Corp. | Bioactive glass scaffolds, and method of making |
| KR101941244B1 (ko) * | 2012-03-26 | 2019-01-22 | 모사이 코퍼레이션. | 생활성 유리 지지체 및 이의 제조방법 |
| US8449904B1 (en) | 2012-03-26 | 2013-05-28 | Mosci, Corp. | Bioactive glass scaffolds, and method of making |
| US11225430B2 (en) | 2012-03-26 | 2022-01-18 | Steven Jung | Bioactive glass scaffolds, and method of making |
| KR102107257B1 (ko) * | 2012-05-24 | 2020-05-07 | 다케다 에이에스 | 포장재 |
| JP2015517879A (ja) * | 2012-05-30 | 2015-06-25 | ニューヨーク ユニバーシティ | 組織修復デバイスまたは足場 |
| US9339392B2 (en) | 2012-08-02 | 2016-05-17 | Prosidyan, Inc. | Method of dose controlled application of bone graft materials by weight |
| US20140207248A1 (en) * | 2013-01-18 | 2014-07-24 | The Trustees Of The Stevens Institute Of Technology | Hierarchical multiscale fibrous scaffold via 3-d electrostatic deposition prototyping and conventional electrospinning |
| US8883195B2 (en) | 2013-03-14 | 2014-11-11 | Prosidyan, Inc. | Bioactive porous bone graft implants |
| US8889178B2 (en) | 2013-03-14 | 2014-11-18 | Prosidyan, Inc | Bioactive porous bone graft compositions in synthetic containment |
| US9381274B2 (en) | 2013-03-14 | 2016-07-05 | Prosidyan, Inc. | Bone graft implants containing allograft |
| EP2968658B1 (en) | 2013-03-14 | 2021-09-08 | Prosidyan, Inc. | Bioactive porous composite bone graft implants |
| US20140277505A1 (en) * | 2013-03-15 | 2014-09-18 | Dale Mitchell | Spinal implants with bioactive glass markers |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| CN106310379A (zh) * | 2016-08-30 | 2017-01-11 | 谢秋艳 | 一种改性纳米仿生复合材料及其应用 |
| FR3058041B1 (fr) | 2016-10-28 | 2021-06-04 | Centre Hospitalier Regional Univ Lille | Dispositif apte a etre implante dans le corps d'un sujet pour former un implant - masse tissulaire et procede associes. |
| CN106620882A (zh) * | 2016-11-18 | 2017-05-10 | 北京积水潭医院 | 具有密度梯度的人工骨结构 |
| CN108324987B (zh) * | 2018-02-09 | 2020-11-24 | 华南理工大学 | 一种中空多孔球形颗粒人工骨及其制备方法和应用 |
| CN109364307A (zh) * | 2018-10-15 | 2019-02-22 | 福建工程学院 | 一种梯度多孔骨支架材料及其制备方法 |
| US11090412B2 (en) | 2018-12-21 | 2021-08-17 | Zavation Medical Products Llc | Bone repair composition and kit |
| US11426280B2 (en) * | 2019-07-22 | 2022-08-30 | Warsaw Orthopedic, Inc. | Implantable compositions having fibers and methods of making and using them |
| WO2021043950A1 (en) * | 2019-09-04 | 2021-03-11 | Bellaseno Gmbh | Soft tissue reconstruction implants and forming method therefor |
| US11583403B2 (en) * | 2019-11-15 | 2023-02-21 | Warsaw Orthopedic, Inc. | Bone implant holding and shaping tray |
| JP7674357B2 (ja) * | 2019-12-20 | 2025-05-09 | テファ， インコーポレイテッド | 骨欠損部再建用の再吸収性インプラント |
| AU2020445491A1 (en) * | 2020-05-01 | 2022-12-08 | SECADA MEDICAL LLC dba VENTRIS MEDICAL, LLC | Bone graft containment system |
| US20220016312A1 (en) * | 2020-07-17 | 2022-01-20 | Zetagen Therapeutics, Inc. | Methods and compositions to graft bone using iron excipients |
| JP2022044295A (ja) * | 2020-09-07 | 2022-03-17 | パナソニックＩｐマネジメント株式会社 | 繊維シート、繊維シートの製造方法、および細胞培養チップ |
| CN114432009A (zh) * | 2020-11-05 | 2022-05-06 | 上海三友医疗器械股份有限公司 | 承载结构 |
| WO2023056347A1 (en) * | 2021-09-29 | 2023-04-06 | Allumin8, Llc | Scaffold, devices, and related methods for bone implantation |
| US20250099140A1 (en) * | 2022-01-12 | 2025-03-27 | Orthofumdamentals, Llc | Medical implants for generating fusion between two bones |
| CN114887116B (zh) * | 2022-03-23 | 2023-04-07 | 广州医科大学附属口腔医院（广州医科大学羊城医院） | 一种负载间充质干细胞外基质的3d打印骨缺损修复支架及其制备方法 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030233A (en) | 1984-10-17 | 1991-07-09 | Paul Ducheyne | Porous flexible metal fiber material for surgical implantation |
| CA1264674A (en) | 1984-10-17 | 1990-01-23 | Paul Ducheyne | Porous flexible metal fiber material for surgical implantation |
| US4861733A (en) | 1987-02-13 | 1989-08-29 | Interpore International | Calcium phosphate bone substitute materials |
| JPH06116114A (ja) * | 1992-10-09 | 1994-04-26 | Nikon Corp | 骨充填材 |
| FI101129B (sv) | 1995-01-13 | 1998-04-30 | Vivoxid Oy | Nya bioaktiva glas och deras användning |
| US5776193A (en) | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| US6902584B2 (en) | 1995-10-16 | 2005-06-07 | Depuy Spine, Inc. | Bone grafting matrix |
| DE69840171D1 (de) | 1997-05-30 | 2008-12-11 | Osteobiologics Inc | Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung |
| US6139585A (en) | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
| US6406498B1 (en) | 1998-09-04 | 2002-06-18 | Bionx Implants Oy | Bioactive, bioabsorbable surgical composite material |
| US6398814B1 (en) * | 1998-09-14 | 2002-06-04 | Bionx Implants Oy | Bioabsorbable two-dimensional multi-layer composite device and a method of manufacturing same |
| FI110063B (fi) * | 1998-12-11 | 2002-11-29 | Antti Yli-Urpo | Uusi bioaktiivinen tuote ja sen käyttö |
| US6482444B1 (en) * | 1999-06-14 | 2002-11-19 | Imperial College Innovations | Silver-containing, sol/gel derived bioglass compositions |
| JP2004501719A (ja) | 2000-07-03 | 2004-01-22 | オステオテック インコーポレーテッド | 骨から誘導された骨形成性インプラント |
| US20040265385A1 (en) * | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| FI117963B (fi) * | 2001-04-26 | 2007-05-15 | Eija Marjut Pirhonen | Luuta korvaavat materiaalit |
| US20040009598A1 (en) * | 2001-07-11 | 2004-01-15 | Hench Larry L | Use of bioactive glass compositions to stimulate osteoblast production |
| US6955716B2 (en) * | 2002-03-01 | 2005-10-18 | American Dental Association Foundation | Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates |
| EP1344538A1 (en) | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
| AU2003304348A1 (en) * | 2002-03-15 | 2005-02-04 | The Trustees Of The University Of Pennsylvania | Fibrous composite for tissue engineering |
| AU2003251899A1 (en) * | 2002-07-10 | 2004-01-23 | University Of Florida | Sol-gel derived bioactive glass polymer composite |
| US20040078090A1 (en) * | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
| US20050118236A1 (en) * | 2002-12-03 | 2005-06-02 | Gentis Inc. | Bioactive, resorbable scaffolds for tissue engineering |
| US8197837B2 (en) * | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
| US20040197375A1 (en) | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| AU2004241740B2 (en) * | 2003-05-22 | 2010-03-25 | Artoss Gmbh | Inorganic resorbable bone substitute material |
| FI120333B (fi) * | 2003-08-20 | 2009-09-30 | Bioretec Oy | Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi |
| US20050090905A1 (en) | 2003-10-23 | 2005-04-28 | Hawkins Michael E. | Porous implant with a dried, lubricious when wet, in vivo absorbable coating |
| EP1729675A4 (en) | 2004-03-05 | 2011-05-18 | Univ Columbia | MULTI-PHASE BIODEGRADABLE AND EAST-INTEGRATIVE COMPOSITE SCULPTURE FOR THE BIOLOGICAL FIXATION OF SKELETAL MOLECULAR WEAVE ON BONE |
| US8163030B2 (en) | 2004-05-06 | 2012-04-24 | Degradable Solutions Ag | Biocompatible bone implant compositions and methods for repairing a bone defect |
| FR2873683B1 (fr) * | 2004-07-27 | 2007-06-15 | Inst Nat Sciences Appliq | Bioverre poreux et procede de preparation |
| WO2006083375A2 (en) * | 2004-11-29 | 2006-08-10 | North Carolina State University | Metal foam comprising hollow metal spheres and solid matrix and methods of preparation thereof |
| US8535357B2 (en) * | 2004-12-09 | 2013-09-17 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
| US7621963B2 (en) | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
| WO2006118554A1 (en) | 2005-05-02 | 2006-11-09 | Shanghai Institute Of Ceramics | A degradable, macroporous bioactive glass scaffold as well as its preparation and manufacturing methods |
| FI20055304L (fi) * | 2005-06-13 | 2007-02-20 | Bioretec Oy | Bioabsorboituva implantti, jolla on muuttuva ominaisuus |
| BRPI0612602A2 (pt) | 2005-07-01 | 2010-11-23 | Cinv Ag | dispositivos médicos compreendendo um material compósito reticulado |
| US8690957B2 (en) * | 2005-12-21 | 2014-04-08 | Warsaw Orthopedic, Inc. | Bone graft composition, method and implant |
| US20070240601A1 (en) | 2006-04-14 | 2007-10-18 | Ming Cherng Chou | Biodegradable BB Pellet |
| WO2007124511A2 (en) * | 2006-04-25 | 2007-11-01 | Washington State University | Resorbable ceramics with controlled strength loss rates |
| GB0612028D0 (en) | 2006-06-16 | 2006-07-26 | Imp Innovations Ltd | Bioactive glass |
| CA2656050C (en) * | 2006-06-29 | 2015-02-03 | Orthovita, Inc. | Kit for bone graft comprising collagen,calcium phosphate,and bioactive glass |
| ES2338694T3 (es) | 2006-09-20 | 2010-05-11 | Inion Oy | Composiciones de vidrio bioactivo. |
| JP2010507413A (ja) * | 2006-10-23 | 2010-03-11 | アイトゲネシッシェ テヒニッシェ ホーホシューレ チューリッヒ | インプラント材料 |
| US8753391B2 (en) | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
| WO2008122595A2 (en) * | 2007-04-05 | 2008-10-16 | Cinvention Ag | Biodegradable therapeutic implant for bone or cartilage repair |
| ITTO20070373A1 (it) | 2007-05-29 | 2008-11-30 | Torino Politecnico | Coppa acetabolare ceramica monoblocco per protesi d'anca. |
| FR2918658B1 (fr) | 2007-07-09 | 2010-12-03 | Centre Nat Rech Scient | Verres bioactifs dopes en strontium. |
| US20100136086A1 (en) * | 2008-05-12 | 2010-06-03 | Day Thomas E | Dynamic bioactive nanofiber scaffolding |
| KR100932949B1 (ko) * | 2008-07-14 | 2009-12-21 | 한국기계연구원 | 계층적 기공구조를 포함하는 다공성 세라믹 볼 및 이의제조방법 |
| EP3251618B8 (en) * | 2009-01-16 | 2019-11-13 | Carbofix Orthopedics Ltd. | Composite material bone implant |
| BRPI1014607B1 (pt) | 2009-06-29 | 2022-09-27 | Bonalive Biomaterials Oy | Vidro bioativo para o uso em condições relativas a infecções ósseas |
| JP5711735B2 (ja) | 2009-07-10 | 2015-05-07 | バイオ２ テクノロジーズ，インク． | 生体組織工学のためのデバイスおよび方法 |
| US20110206828A1 (en) | 2009-07-10 | 2011-08-25 | Bio2 Technologies, Inc. | Devices and Methods for Tissue Engineering |
| WO2011031821A1 (en) * | 2009-09-09 | 2011-03-17 | The Ohio State University Research Foundation | Glass ceramic scaffolds with complex topography |
| EP2485780A4 (en) | 2009-10-07 | 2014-05-21 | Bio2 Technologies Inc | DEVICES AND METHOD FOR TISSUE BREEDING |
| CA2779109A1 (en) | 2009-10-29 | 2011-05-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material having an engineered porosity |
| EP2493425B1 (en) | 2009-10-29 | 2016-10-05 | Prosidyan, Inc. | Dynamic bioactive bone graft material and methods for handling |
| EP2322134B1 (en) | 2009-11-12 | 2012-09-12 | BonAlive Biomaterials Oy | Implantable paste and its use |
| US8734831B2 (en) | 2010-04-16 | 2014-05-27 | Snu R&Db Foundation | Method for manufacturing a porous ceramic scaffold having an organic/inorganic hybrid coating layer containing a bioactive factor |
| JP5801382B2 (ja) | 2010-05-06 | 2015-10-28 | バイオ２ テクノロジーズ，インク． | 生体組織再生のための医療用デバイスおよび方法 |
| US20120265167A1 (en) | 2010-12-21 | 2012-10-18 | Simonson Rush E | Biocompatible material for orthopedic uses |
| EP2522373A1 (en) | 2011-05-11 | 2012-11-14 | Dentsply IH AB | Biocompatible component |
| US8889178B2 (en) * | 2013-03-14 | 2014-11-18 | Prosidyan, Inc | Bioactive porous bone graft compositions in synthetic containment |
| US9381274B2 (en) * | 2013-03-14 | 2016-07-05 | Prosidyan, Inc. | Bone graft implants containing allograft |
-
2010
- 2010-10-28 CA CA2779109A patent/CA2779109A1/en not_active Abandoned
- 2010-10-28 EP EP10827483.8A patent/EP2493519B1/en active Active
- 2010-10-28 EP EP18167603.2A patent/EP3372253B1/en active Active
- 2010-10-28 ES ES10827483.8T patent/ES2672590T3/es active Active
- 2010-10-28 CN CN201080049374.2A patent/CN102596271B/zh active Active
- 2010-10-28 WO PCT/US2010/054535 patent/WO2011053719A1/en not_active Ceased
- 2010-10-28 US US12/914,468 patent/US20110144763A1/en not_active Abandoned
- 2010-10-28 KR KR1020127013506A patent/KR20120099058A/ko not_active Withdrawn
- 2010-10-28 JP JP2012537071A patent/JP5792736B2/ja active Active
- 2010-10-28 MX MX2012004917A patent/MX2012004917A/es not_active Application Discontinuation
- 2010-10-28 ES ES18167603T patent/ES2901457T3/es active Active
- 2010-10-28 AU AU2010313415A patent/AU2010313415B2/en active Active
-
2019
- 2019-11-26 US US16/695,997 patent/US11338061B2/en active Active
-
2022
- 2022-05-23 US US17/750,861 patent/US20230077763A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP5792736B2 (ja) | 2015-10-14 |
| CN102596271A (zh) | 2012-07-18 |
| US20200093963A1 (en) | 2020-03-26 |
| US11338061B2 (en) | 2022-05-24 |
| AU2010313415A1 (en) | 2012-05-10 |
| EP3372253A1 (en) | 2018-09-12 |
| EP3372253B1 (en) | 2021-10-20 |
| EP2493519A1 (en) | 2012-09-05 |
| CA2779109A1 (en) | 2011-05-05 |
| US20110144763A1 (en) | 2011-06-16 |
| KR20120099058A (ko) | 2012-09-06 |
| ES2901457T3 (es) | 2022-03-22 |
| JP2013509260A (ja) | 2013-03-14 |
| EP2493519B1 (en) | 2018-04-18 |
| US20230077763A1 (en) | 2023-03-16 |
| WO2011053719A1 (en) | 2011-05-05 |
| CN102596271B (zh) | 2017-09-08 |
| AU2010313415B2 (en) | 2015-09-03 |
| EP2493519A4 (en) | 2014-04-30 |
| MX2012004917A (es) | 2012-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2672590T3 (es) | Material dinámico de injerto óseo bioactivo que tiene una porosidad diseñada | |
| US8567162B2 (en) | Dynamic bioactive bone graft material and methods for handling | |
| US20110144764A1 (en) | Bone graft material | |
| US10478528B2 (en) | Bone graft implants containing allograft | |
| EP2968658B1 (en) | Bioactive porous composite bone graft implants | |
| AU2014240175B2 (en) | Bioactive porous bone graft implants |