ES2670423T3 - Inhibidores de multicinasas para uso en el tratamiento de cáncer - Google Patents
Inhibidores de multicinasas para uso en el tratamiento de cáncer Download PDFInfo
- Publication number
- ES2670423T3 ES2670423T3 ES08796672.7T ES08796672T ES2670423T3 ES 2670423 T3 ES2670423 T3 ES 2670423T3 ES 08796672 T ES08796672 T ES 08796672T ES 2670423 T3 ES2670423 T3 ES 2670423T3
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- compound
- cancer
- leukemia
- flt3
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Organic Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US951901P | 2007-07-25 | ||
| US2919608P | 2008-02-15 | 2008-02-15 | |
| US29196P | 2008-02-15 | ||
| PCT/US2008/071256 WO2009015368A2 (en) | 2007-07-25 | 2008-07-25 | Multikinase inhibitors for use in the treatment of cancer |
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| ES (1) | ES2670423T3 (enExample) |
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| WO (1) | WO2009015368A2 (enExample) |
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| CA2478065C (en) * | 2002-03-08 | 2013-01-08 | Eisai Co. Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| CN105748465A (zh) | 2007-07-25 | 2016-07-13 | 卫材R&D管理株式会社 | 用于治疗癌症的多激酶抑制剂 |
| EP2453234B1 (en) * | 2007-10-29 | 2014-01-15 | Eisai R&D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
| MX2010005999A (es) * | 2007-12-07 | 2010-06-23 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de analogos de macrolidos de zearalenona. |
| WO2012027716A1 (en) * | 2010-08-27 | 2012-03-01 | Collabrx, Inc. | Method to treat melanoma in braf inhibitor-resistant subjects |
| CN105338977B (zh) * | 2013-06-26 | 2018-10-16 | 卫材R&D管理有限公司 | 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途 |
| US11136625B2 (en) | 2013-08-28 | 2021-10-05 | Crown Bioscience, Inc. (Taicang) | Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same |
| WO2015181628A1 (en) * | 2014-05-27 | 2015-12-03 | Eisai R&D Management Co., Ltd. | Treatment of acute myeloid leukemia with an hck inhibitor |
| WO2022053130A1 (en) * | 2020-09-09 | 2022-03-17 | Sid Alex Group, S.R.O. | Antago-mir-155 for treatment of v-src, c-src-tyrosine kinase-induced cancers |
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| GB9225396D0 (en) | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JPH0840893A (ja) | 1993-08-31 | 1996-02-13 | Takeda Chem Ind Ltd | インターロイキン−１産生抑制剤 |
| DE4420930C2 (de) | 1994-06-16 | 1997-05-22 | Daimler Benz Ag | Vorrichtung und Verfahren zum Steuern einer selbsttätigen Schaltvorrichtung eines Gangwechselgetriebes eines Kraftfahrzeuges |
| US5795910A (en) | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US5727726A (en) * | 1996-06-14 | 1998-03-17 | Newco Pneumatic Corp. | Cassette assembly for a stapling mechanism |
| WO1998038162A1 (en) | 1997-02-27 | 1998-09-03 | Eisai Co., Ltd. | Inhibitors of isoprenyl transferase |
| GB2323845A (en) | 1997-03-31 | 1998-10-07 | Merck & Co Inc | MEK inhibiting lactones |
| AU779438B2 (en) | 1998-12-24 | 2005-01-27 | Novation Pharmaceuticals Inc. | Compounds which affect mRNA stability and uses therefor |
| GB9828709D0 (en) | 1998-12-24 | 1999-02-17 | Novartis Ag | Assay |
| DE60042921D1 (de) * | 1999-03-29 | 2009-10-22 | Shire Canada Inc | Verwendung von cytidinderivaten zur behandlung von leukämie |
| WO2001036003A2 (en) | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
| CA2397417A1 (en) | 2000-01-12 | 2001-07-19 | Sarah S. Bacus | Method for quantitating a protein by image analysis |
| JP4317913B2 (ja) | 2000-04-14 | 2009-08-19 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | Ａｋｔタンパク質発現の定量方法 |
| JP2001294527A (ja) | 2000-04-14 | 2001-10-23 | Ajinomoto Co Inc | Ｔｈ２反応に特異的な免疫寛容誘導剤 |
| JP2004292314A (ja) | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
| JP2004292315A (ja) | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | Ｔａｋ１阻害剤 |
| US7071164B2 (en) | 2001-08-16 | 2006-07-04 | Kimberly-Clark Worldwide, Inc. | Anti-cancer and wound healing compounds |
| EP2277991A1 (en) | 2001-08-21 | 2011-01-26 | Ventana Medical Systems, Inc. | Method and quantification assay for determining c-kit/SCF/pAKT status |
| EP1456364B1 (en) | 2001-12-21 | 2011-03-23 | The Wellcome Trust | Mutations in the b-raf gene |
| US20040096855A1 (en) | 2001-12-24 | 2004-05-20 | Michael Stratton | Genes |
| US7915306B2 (en) | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| CA2478065C (en) | 2002-03-08 | 2013-01-08 | Eisai Co. Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| PL1663978T3 (pl) | 2003-07-23 | 2008-04-30 | Bayer Healthcare Llc | Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów |
| WO2005047542A1 (en) | 2003-10-16 | 2005-05-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatments for inhibiting development and progression of nevi and melanoma having braf mutations |
| US20050214325A1 (en) | 2004-03-26 | 2005-09-29 | Vvii Newco 2003, Inc. | Compositions and methods to increase the effect of a neurotoxin treatment |
| MXPA06010667A (es) | 2004-03-19 | 2007-07-04 | Penn State Res Found | Metodos combinatorios y composiciones para el tratamiento de melanoma. |
| BRPI0509580A (pt) | 2004-03-30 | 2007-11-27 | Pfizer Prod Inc | combinações de inibidores de transdução de sinal |
| CA2569277A1 (en) | 2004-06-04 | 2005-12-15 | Pfizer Products Inc. | Method for treating abnormal cell growth |
| US20060079494A1 (en) * | 2004-09-27 | 2006-04-13 | Santi Daniel V | Specific kinase inhibitors |
| US20060216288A1 (en) | 2005-03-22 | 2006-09-28 | Amgen Inc | Combinations for the treatment of cancer |
| US7812143B2 (en) | 2006-03-31 | 2010-10-12 | Memorial Sloan-Kettering Cancer Center | Biomarkers for cancer treatment |
| CN105748465A (zh) | 2007-07-25 | 2016-07-13 | 卫材R&D管理株式会社 | 用于治疗癌症的多激酶抑制剂 |
| EP2453234B1 (en) | 2007-10-29 | 2014-01-15 | Eisai R&D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
| MX2010005999A (es) | 2007-12-07 | 2010-06-23 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de analogos de macrolidos de zearalenona. |
| US8578879B2 (en) * | 2009-07-29 | 2013-11-12 | Applied Materials, Inc. | Apparatus for VHF impedance match tuning |
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| US20180353468A1 (en) | 2018-12-13 |
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| AU2008279027A1 (en) | 2009-01-29 |
| CN101778627B (zh) | 2016-04-13 |
| KR20160123390A (ko) | 2016-10-25 |
| IL247230A (en) | 2017-04-30 |
| US20130303489A1 (en) | 2013-11-14 |
| CN101778627A (zh) | 2010-07-14 |
| IL202307A0 (en) | 2010-06-30 |
| US11160783B2 (en) | 2021-11-02 |
| US8937056B2 (en) | 2015-01-20 |
| KR20150138417A (ko) | 2015-12-09 |
| US8609640B2 (en) | 2013-12-17 |
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| JP2013189458A (ja) | 2013-09-26 |
| EP2182941B1 (en) | 2018-02-28 |
| WO2009015368A3 (en) | 2009-03-26 |
| WO2009015368A2 (en) | 2009-01-29 |
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