ES2661575T3 - Producción de polímeros de heparosano de peso molecular alto y métodos de producción y uso de los mismos - Google Patents

Producción de polímeros de heparosano de peso molecular alto y métodos de producción y uso de los mismos Download PDF

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Publication number
ES2661575T3
ES2661575T3 ES13767739.9T ES13767739T ES2661575T3 ES 2661575 T3 ES2661575 T3 ES 2661575T3 ES 13767739 T ES13767739 T ES 13767739T ES 2661575 T3 ES2661575 T3 ES 2661575T3
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ES
Spain
Prior art keywords
pmhs
heparosan
native
polypeptide
opt3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13767739.9T
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English (en)
Spanish (es)
Inventor
Paul L. Deangelis
Philip PUMMILL
Regina C. VISSIER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
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University of Oklahoma
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Publication of ES2661575T3 publication Critical patent/ES2661575T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polymers & Plastics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
ES13767739.9T 2012-03-30 2013-03-29 Producción de polímeros de heparosano de peso molecular alto y métodos de producción y uso de los mismos Active ES2661575T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261617952P 2012-03-30 2012-03-30
US201261617952P 2012-03-30
PCT/US2013/034631 WO2013149161A1 (en) 2012-03-30 2013-03-29 High molecular weight heparosan polymers and methods of production and use thereof

Publications (1)

Publication Number Publication Date
ES2661575T3 true ES2661575T3 (es) 2018-04-02

Family

ID=49235840

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13767739.9T Active ES2661575T3 (es) 2012-03-30 2013-03-29 Producción de polímeros de heparosano de peso molecular alto y métodos de producción y uso de los mismos

Country Status (10)

Country Link
US (5) US8980608B2 (enExample)
EP (1) EP2831237B1 (enExample)
AU (1) AU2013237894B2 (enExample)
BR (1) BR112014024291B1 (enExample)
CA (1) CA2869128C (enExample)
DK (1) DK2831237T3 (enExample)
ES (1) ES2661575T3 (enExample)
PL (1) PL2831237T3 (enExample)
TR (1) TR201802761T4 (enExample)
WO (1) WO2013149161A1 (enExample)

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US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
EP2831237B1 (en) 2012-03-30 2017-11-29 The Board of Regents of the University of Oklahoma High molecular weight heparosan polymers and methods of production and use thereof
AR099900A1 (es) * 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
US20160114050A1 (en) * 2014-10-23 2016-04-28 The Board Of Regents Of The University Of Oklahoma Heparosan/Therapeutic Prodrug Complexes and Methods of Making and Using Same
CN105602980B (zh) * 2016-01-25 2019-02-01 浙江工业大学 一种waaR基因缺陷型细菌合成低分子量肝素前体的方法
CN108699161B (zh) 2016-03-04 2022-06-03 莫佛塞斯公司 多发性骨髓瘤中m-蛋白应答的临床评估
CA3126805A1 (en) 2019-01-15 2020-07-23 Optimvia, Llc Engineered aryl sulfate-dependent enzymes
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
WO2021199444A1 (en) * 2020-04-03 2021-10-07 Rensselaer Polytechnic Institute Method for producing heparosan and bacterium of genus escherichia having heparosan-producing ability

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Also Published As

Publication number Publication date
US20180251803A1 (en) 2018-09-06
US20170198325A1 (en) 2017-07-13
EP2831237A1 (en) 2015-02-04
DK2831237T3 (en) 2018-03-05
EP2831237A4 (en) 2016-04-13
US20150150900A1 (en) 2015-06-04
AU2013237894A1 (en) 2014-10-30
EP2831237B1 (en) 2017-11-29
US10392642B2 (en) 2019-08-27
US8980608B2 (en) 2015-03-17
US9885072B2 (en) 2018-02-06
WO2013149161A1 (en) 2013-10-03
CA2869128A1 (en) 2013-10-03
CA2869128C (en) 2022-07-26
PL2831237T3 (pl) 2018-06-29
BR112014024291A2 (enExample) 2017-06-20
BR112014024291B1 (pt) 2022-07-05
AU2013237894B2 (en) 2018-06-21
US20140107066A1 (en) 2014-04-17
US20130261079A1 (en) 2013-10-03
TR201802761T4 (tr) 2018-03-21

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