ES2651762T3 - Anticuerpo monoclonal humano contra la toxina alfa derivada de S. aureus y su uso en el tratamiento o prevención de la formación de abscesos - Google Patents
Anticuerpo monoclonal humano contra la toxina alfa derivada de S. aureus y su uso en el tratamiento o prevención de la formación de abscesos Download PDFInfo
- Publication number
- ES2651762T3 ES2651762T3 ES14195810.8T ES14195810T ES2651762T3 ES 2651762 T3 ES2651762 T3 ES 2651762T3 ES 14195810 T ES14195810 T ES 14195810T ES 2651762 T3 ES2651762 T3 ES 2651762T3
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- antibody
- monoclonal antibody
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Radiology & Medical Imaging (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09010311A EP2284193A1 (en) | 2009-08-10 | 2009-08-10 | Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation |
| EP09010311 | 2009-08-10 | ||
| US26633009P | 2009-12-03 | 2009-12-03 | |
| US266330P | 2009-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2651762T3 true ES2651762T3 (es) | 2018-01-29 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| ES14195810.8T Active ES2651762T3 (es) | 2009-08-10 | 2010-08-10 | Anticuerpo monoclonal humano contra la toxina alfa derivada de S. aureus y su uso en el tratamiento o prevención de la formación de abscesos |
| ES10743037.3T Active ES2529175T3 (es) | 2009-08-10 | 2010-08-10 | Anticuerpo monoclonal humano contra la toxina alfa derivada de S. aureus y su uso en el tratamiento o la prevención de la formación de abscesos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10743037.3T Active ES2529175T3 (es) | 2009-08-10 | 2010-08-10 | Anticuerpo monoclonal humano contra la toxina alfa derivada de S. aureus y su uso en el tratamiento o la prevención de la formación de abscesos |
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| Country | Link |
|---|---|
| US (1) | US9249215B2 (enExample) |
| EP (3) | EP2284193A1 (enExample) |
| JP (1) | JP6064241B2 (enExample) |
| KR (1) | KR101836130B1 (enExample) |
| CN (1) | CN102549013B (enExample) |
| CA (1) | CA2769394C (enExample) |
| ES (2) | ES2651762T3 (enExample) |
| IL (1) | IL217746A (enExample) |
| IN (1) | IN2012DN00797A (enExample) |
| RU (1) | RU2529946C9 (enExample) |
| WO (1) | WO2011018208A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140286960A1 (en) * | 2011-07-28 | 2014-09-25 | Cangene Corporation | Staphlococcus aureus alpha-hemolysin antibodies |
| WO2013093693A1 (en) | 2011-12-22 | 2013-06-27 | Rinat Neuroscience Corp. | Staphylococcus aureus specific antibodies and uses thereof |
| WO2013156534A1 (en) | 2012-04-17 | 2013-10-24 | Arsanis Biosciences Gmbh | Cross-reactive staphylococcus aureus antibody |
| CA2890427C (en) * | 2012-11-06 | 2022-05-31 | Medimmune, Llc | Antibodies to s. aureus surface determinants |
| SG10201703677VA (en) * | 2012-11-06 | 2017-06-29 | Medimmune Llc | Methods of treating s. aureus-associated diseases |
| CN104211804A (zh) * | 2014-08-20 | 2014-12-17 | 钱泓 | 一种抗金黄色葡萄球菌多克隆抗体的制备与应用 |
| TWI781130B (zh) | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| AU2020290971A1 (en) * | 2019-06-14 | 2021-12-23 | Dana-Farber Cancer Institute, Inc. | Antibodies against PD-1 and methods of use thereof |
| CN112538112B (zh) | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
| CN113444173A (zh) * | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| US20230374114A1 (en) * | 2020-04-16 | 2023-11-23 | Dana-Farber Cancer Institute, Inc. | Coronavirus antibodies and methods of use thereof |
| WO2021233408A1 (zh) * | 2020-05-21 | 2021-11-25 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其稳定制剂 |
| WO2023208123A1 (zh) * | 2022-04-28 | 2023-11-02 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997043314A2 (en) * | 1996-05-16 | 1997-11-20 | The Texas A & M University System | Collagen binding protein compositions and methods of use |
| EA018030B1 (ru) * | 2006-06-06 | 2013-05-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения |
| AU2007259415B2 (en) | 2006-06-12 | 2013-09-26 | Glaxosmithkline Biologicals Sa | Use of alpha-toxin for treating and preventing Staphylococcus infections |
| CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
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2009
- 2009-08-10 EP EP09010311A patent/EP2284193A1/en not_active Withdrawn
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2010
- 2010-08-10 IN IN797DEN2012 patent/IN2012DN00797A/en unknown
- 2010-08-10 CN CN201080044958.0A patent/CN102549013B/zh active Active
- 2010-08-10 ES ES14195810.8T patent/ES2651762T3/es active Active
- 2010-08-10 WO PCT/EP2010/004884 patent/WO2011018208A1/en not_active Ceased
- 2010-08-10 JP JP2012524142A patent/JP6064241B2/ja not_active Expired - Fee Related
- 2010-08-10 US US13/388,254 patent/US9249215B2/en active Active
- 2010-08-10 EP EP10743037.3A patent/EP2464665B1/en active Active
- 2010-08-10 EP EP14195810.8A patent/EP2860191B1/en active Active
- 2010-08-10 RU RU2012105045/10A patent/RU2529946C9/ru active
- 2010-08-10 CA CA2769394A patent/CA2769394C/en active Active
- 2010-08-10 KR KR1020127004737A patent/KR101836130B1/ko not_active Expired - Fee Related
- 2010-08-10 ES ES10743037.3T patent/ES2529175T3/es active Active
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- 2012-01-26 IL IL217746A patent/IL217746A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6064241B2 (ja) | 2017-01-25 |
| CA2769394C (en) | 2019-06-25 |
| US9249215B2 (en) | 2016-02-02 |
| ES2529175T3 (es) | 2015-02-17 |
| EP2284193A1 (en) | 2011-02-16 |
| KR101836130B1 (ko) | 2018-03-08 |
| US20120201829A1 (en) | 2012-08-09 |
| WO2011018208A1 (en) | 2011-02-17 |
| IL217746A (en) | 2016-05-31 |
| RU2529946C2 (ru) | 2014-10-10 |
| CN102549013A (zh) | 2012-07-04 |
| KR20120047270A (ko) | 2012-05-11 |
| JP2013501506A (ja) | 2013-01-17 |
| CA2769394A1 (en) | 2011-02-17 |
| IN2012DN00797A (enExample) | 2015-06-26 |
| RU2529946C9 (ru) | 2015-03-27 |
| EP2860191B1 (en) | 2017-10-11 |
| CN102549013B (zh) | 2015-05-06 |
| IL217746A0 (en) | 2012-03-29 |
| EP2464665B1 (en) | 2014-12-03 |
| RU2012105045A (ru) | 2013-09-20 |
| EP2860191A1 (en) | 2015-04-15 |
| EP2464665A1 (en) | 2012-06-20 |
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