ES2637811T3 - Membrana espaciadora mejorada para un sensor enzimático in vivo - Google Patents

Membrana espaciadora mejorada para un sensor enzimático in vivo Download PDF

Info

Publication number
ES2637811T3
ES2637811T3 ES13712795.7T ES13712795T ES2637811T3 ES 2637811 T3 ES2637811 T3 ES 2637811T3 ES 13712795 T ES13712795 T ES 13712795T ES 2637811 T3 ES2637811 T3 ES 2637811T3
Authority
ES
Spain
Prior art keywords
methacrylate
hydrophilic
electrode system
copolymer
acrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13712795.7T
Other languages
English (en)
Spanish (es)
Inventor
Arnulf Staib
Marcel Thiele
Karl-Heinz Koelker
Ewald Rieger
Alexander Licht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diabetes Care GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diabetes Care GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44511772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2637811(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG, Roche Diabetes Care GmbH filed Critical F Hoffmann La Roche AG
Priority claimed from PCT/EP2013/056619 external-priority patent/WO2013144255A1/en
Application granted granted Critical
Publication of ES2637811T3 publication Critical patent/ES2637811T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
ES13712795.7T 2011-03-28 2013-03-27 Membrana espaciadora mejorada para un sensor enzimático in vivo Active ES2637811T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11160007 2011-03-28
WOPCT/EP2012/055406 2012-03-27
PCT/EP2012/055406 WO2012130841A1 (en) 2011-03-28 2012-03-27 Improved diffusion layer for an enzymatic in-vivo sensor
PCT/EP2013/056619 WO2013144255A1 (en) 2012-03-27 2013-03-27 Improved spacer membrane for an enzymatic in-vivo sensor

Publications (1)

Publication Number Publication Date
ES2637811T3 true ES2637811T3 (es) 2017-10-17

Family

ID=44511772

Family Applications (2)

Application Number Title Priority Date Filing Date
ES17169444T Active ES2707347T3 (es) 2011-03-28 2013-03-27 Membrana espaciadora mejorada para un sensor enzimático in vivo
ES13712795.7T Active ES2637811T3 (es) 2011-03-28 2013-03-27 Membrana espaciadora mejorada para un sensor enzimático in vivo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES17169444T Active ES2707347T3 (es) 2011-03-28 2013-03-27 Membrana espaciadora mejorada para un sensor enzimático in vivo

Country Status (14)

Country Link
US (3) US10422765B2 (pl)
EP (1) EP2697388B1 (pl)
KR (1) KR20130122696A (pl)
CN (1) CN103443286B (pl)
AU (1) AU2012234345A1 (pl)
BR (1) BR112014021373B1 (pl)
DK (2) DK2697388T3 (pl)
ES (2) ES2707347T3 (pl)
HK (2) HK1191984A1 (pl)
IL (1) IL234190B (pl)
MX (1) MX2013011041A (pl)
PL (1) PL2697388T3 (pl)
SI (1) SI2697388T1 (pl)
WO (1) WO2012130841A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9788765B2 (en) 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
EP2774538B1 (en) * 2013-03-06 2022-05-25 Roche Diabetes Care GmbH Process for detecting an analyte using a sensor with Mn2O3 catalyst
US9737250B2 (en) 2013-03-15 2017-08-22 Dexcom, Inc. Membrane for continuous analyte sensors
CA2998398C (en) * 2015-12-30 2023-09-19 Dexcom, Inc. Biointerface layer for analyte sensors
EP3263712A1 (en) * 2016-06-29 2018-01-03 Roche Diabetes Care GmbH Galvanically functionalized sensors
EP3950952A1 (en) 2016-12-08 2022-02-09 Roche Diabetes Care GmbH Sensor device for determining the concentration of an analyte under in-vivo conditions and process of manufacturing
ES2969074T3 (es) 2017-02-17 2024-05-16 Hoffmann La Roche Electrodo de monitorización continua de analito con enzima reticulada
EP3787509B1 (en) * 2018-05-04 2022-06-22 F. Hoffmann-La Roche AG Improved diffusion layer for an enzymatic in-vivo sensor
AU2019346733A1 (en) * 2018-09-27 2021-04-08 I-Sens, Inc. Polymer blend for controlling blood glucose influx, and continuous glucose monitoring biosensor comprising same
TW202203850A (zh) 2020-03-13 2022-02-01 瑞士商赫孚孟拉羅股份公司 製備工作電極的方法
EP4179104A1 (en) 2020-07-07 2023-05-17 F. Hoffmann-La Roche AG Analyte sensor and its manufacturing
CN116297765A (zh) * 2020-09-01 2023-06-23 深圳硅基传感科技有限公司 生物传感器的聚合物膜
CN116419710A (zh) 2020-11-20 2023-07-11 豪夫迈·罗氏有限公司 通量限制性聚合物膜
WO2022106668A1 (en) 2020-11-23 2022-05-27 F. Hoffmann-La Roche Ag Method for preparing a working electrode
EP4000517A1 (en) 2020-11-23 2022-05-25 Roche Diabetes Care GmbH Working electrode for an analyte sensor
CA3196288A1 (en) 2020-11-24 2022-06-02 Kirill Sliozberg Method for preparing a counter/reference electrode
EP4130729A1 (en) * 2021-08-04 2023-02-08 Roche Diabetes Care GmbH Opening formation in a membrane of a biosensor
EP4115806A1 (en) 2021-07-06 2023-01-11 Roche Diabetes Care GmbH Analyte sensor and method for manufacturing an analyte sensor
WO2023283096A1 (en) 2021-07-06 2023-01-12 Roche Diabetes Care, Inc. Analyte sensor and method for manufacturing an analyte sensor
EP4140408A1 (en) 2021-08-30 2023-03-01 Roche Diabetes Care GmbH Membrane with biodegradable polymer
EP4151151A1 (en) 2021-09-21 2023-03-22 F. Hoffmann-La Roche AG Sensor with varying stiffness
AU2022421139A1 (en) 2021-12-24 2024-05-16 Hoffman-La Roche Ag F. Analyte sensor and method for manufacturing an analyte sensor
EP4212095A1 (en) 2022-01-18 2023-07-19 F. Hoffmann-La Roche AG Analyte sensor and method for manufacturing an analyte sensor
KR102389269B1 (ko) * 2022-02-16 2022-04-21 네메시스 주식회사 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542662A (en) 1967-04-18 1970-11-24 Du Pont Enzyme electrode
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4418148A (en) * 1981-11-05 1983-11-29 Miles Laboratories, Inc. Multilayer enzyme electrode membrane
AU1356792A (en) 1991-01-25 1992-08-27 Markwell Medical Institute, Inc. Implantable biological fluid measuring device
US5284140A (en) 1992-02-11 1994-02-08 Eli Lilly And Company Acrylic copolymer membranes for biosensors
US5882494A (en) 1995-03-27 1999-03-16 Minimed, Inc. Polyurethane/polyurea compositions containing silicone for biosensor membranes
US5711861A (en) * 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US7657297B2 (en) 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US6258371B1 (en) 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6024848A (en) * 1998-04-15 2000-02-15 International Fuel Cells, Corporation Electrochemical cell with a porous support plate
WO2000030698A1 (en) * 1998-11-20 2000-06-02 University Of Connecticut Apparatus and method for control of tissue/implant interactions
JP4167595B2 (ja) * 2001-07-24 2008-10-15 日本電気株式会社 酵素電極およびその製造方法
US6751491B2 (en) 2001-09-01 2004-06-15 M Biotech Inc Analyte measuring biosensor chip using image scanning system
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
AU2003209479A1 (en) * 2002-03-11 2003-09-29 First Water Limited Absorbent hydrogels
US9492111B2 (en) 2002-04-22 2016-11-15 Medtronic Minimed, Inc. Methods and materials for stabilizing analyte sensors
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US7232573B1 (en) 2002-09-26 2007-06-19 Advanced Cardiovascular Systems, Inc. Stent coatings containing self-assembled monolayers
US7569222B2 (en) 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
WO2007120442A2 (en) 2003-07-25 2007-10-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8309112B2 (en) 2003-12-24 2012-11-13 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
US7528204B2 (en) * 2004-05-17 2009-05-05 The Goodyear Tire & Rubber Company Hydrogenation and epoxidation of polymers made by controlled polymerization
US7109271B2 (en) 2004-07-28 2006-09-19 Lifescan, Inc. Redox polymers for use in electrochemical-based sensors
US9011831B2 (en) 2004-09-30 2015-04-21 Advanced Cardiovascular Systems, Inc. Methacrylate copolymers for medical devices
US20060121547A1 (en) 2004-12-03 2006-06-08 Mcintire Mark Diffusion layer for an enzyme-based sensor application
JP4763777B2 (ja) 2005-05-17 2011-08-31 ラジオメーター・メディカル・アー・ペー・エス 親水性ポリマーで被覆されたカバー膜層を含む酵素センサー
US20060275859A1 (en) * 2005-05-17 2006-12-07 Kjaer Thomas Enzyme sensor including a water-containing spacer layer
EP2030012A1 (en) 2006-06-19 2009-03-04 Roche Diagnostics GmbH Amperometric sensor and method for its manufacturing
GB0618789D0 (en) 2006-09-23 2006-11-01 Sev Trent Services Ltd Electrolytic cell
RU2444980C2 (ru) 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Трансдермальная система мониторинга аналита и способы детекции аналита
US20100030052A1 (en) 2008-07-31 2010-02-04 Bommakanti Balasubrahmanya S Analyte sensors comprising plasticizers
EP2163190A1 (de) 2008-09-11 2010-03-17 Roche Diagnostics GmbH Elektrodensystem für Messung einer Analytkonzentration in-vivo
WO2011022050A1 (en) * 2009-08-17 2011-02-24 Carnegie Mellon University Procedures for development of specific capacitance in carbon structures
EP2600761A4 (en) 2010-08-06 2014-08-13 Microchips Inc MEMBRANE COMPOSITION FOR BIOSENSOR, BIOSENSOR AND METHODS OF MAKING THE SAME
US20120097554A1 (en) 2010-10-18 2012-04-26 Medtronic Minimed, Inc. Analyte sensors comprising electrodes having selected electrochemical and mechanical properties

Also Published As

Publication number Publication date
WO2012130841A1 (en) 2012-10-04
KR20130122696A (ko) 2013-11-07
SI2697388T1 (sl) 2015-07-31
DK2697388T3 (en) 2015-08-31
BR112014021373A2 (pt) 2017-06-20
BR112014021373B1 (pt) 2021-08-10
PL2697388T3 (pl) 2015-11-30
US20140018653A1 (en) 2014-01-16
CN103443286A (zh) 2013-12-11
US20230258595A1 (en) 2023-08-17
HK1206793A1 (en) 2016-01-15
EP2697388B1 (en) 2015-05-20
HK1191984A1 (zh) 2014-08-08
CN103443286B (zh) 2015-09-23
EP2697388A1 (en) 2014-02-19
DK2831263T3 (en) 2017-09-25
ES2707347T3 (es) 2019-04-03
MX2013011041A (es) 2013-12-06
US20150005605A1 (en) 2015-01-01
US10422765B2 (en) 2019-09-24
AU2012234345A1 (en) 2013-09-05
IL234190B (en) 2019-09-26

Similar Documents

Publication Publication Date Title
ES2637811T3 (es) Membrana espaciadora mejorada para un sensor enzimático in vivo
JP6374860B2 (ja) インビボ酵素センサー用の改良されたスペーサーメンブレン
US20230054564A1 (en) Nad(p)- dependent responsive enzymes, electrodes and sensors, and methods for making and using the same
ES2966036T3 (es) Recubrimiento de biocompatibilidad para la medición continua de analitos
TW201010670A (en) Electrode system for measuring an analyte concentration under in-vivo conditions
KR20230034962A (ko) 분석물 센서 및 그 제조
ES2924910T3 (es) Capa de difusión mejorada para un sensor enzimático in vivo
EP3219807B1 (en) Improved spacer membrane for an enzymatic in-vivo sensor
Lin et al. Redox phospholipid polymer microparticles as doubly functional polymer support for immobilization of enzyme oxidase
TW202402236A (zh) 膜中之開口形成
CN117597068A (zh) 分析物传感器和用于制造分析物传感器的方法
CN117979899A (zh) 具有变化的刚度的传感器