BR112014021373A2 - sistema de eletrodo, sensor e uso de um copolímero hidrofílico. - Google Patents
sistema de eletrodo, sensor e uso de um copolímero hidrofílico.Info
- Publication number
- BR112014021373A2 BR112014021373A2 BR112014021373A BR112014021373A BR112014021373A2 BR 112014021373 A2 BR112014021373 A2 BR 112014021373A2 BR 112014021373 A BR112014021373 A BR 112014021373A BR 112014021373 A BR112014021373 A BR 112014021373A BR 112014021373 A2 BR112014021373 A2 BR 112014021373A2
- Authority
- BR
- Brazil
- Prior art keywords
- sensor
- electrode system
- hydrophilic copolymer
- hydrophilic
- copolymer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q3/00—Condition responsive control processes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11160007 | 2011-03-28 | ||
EPPCT/EP2012/055406 | 2012-03-27 | ||
PCT/EP2012/055406 WO2012130841A1 (en) | 2011-03-28 | 2012-03-27 | Improved diffusion layer for an enzymatic in-vivo sensor |
PCT/EP2013/056619 WO2013144255A1 (en) | 2012-03-27 | 2013-03-27 | Improved spacer membrane for an enzymatic in-vivo sensor |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014021373A2 true BR112014021373A2 (pt) | 2017-06-20 |
BR112014021373B1 BR112014021373B1 (pt) | 2021-08-10 |
Family
ID=44511772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014021373-9A BR112014021373B1 (pt) | 2011-03-28 | 2013-03-27 | Sistema de eletrodo, sensor e uso de um copolímero hidrofílico |
Country Status (14)
Country | Link |
---|---|
US (3) | US10422765B2 (pt) |
EP (1) | EP2697388B1 (pt) |
KR (1) | KR20130122696A (pt) |
CN (1) | CN103443286B (pt) |
AU (1) | AU2012234345A1 (pt) |
BR (1) | BR112014021373B1 (pt) |
DK (2) | DK2697388T3 (pt) |
ES (2) | ES2637811T3 (pt) |
HK (2) | HK1191984A1 (pt) |
IL (1) | IL234190B (pt) |
MX (1) | MX2013011041A (pt) |
PL (1) | PL2697388T3 (pt) |
SI (1) | SI2697388T1 (pt) |
WO (1) | WO2012130841A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9788765B2 (en) | 2012-09-28 | 2017-10-17 | Dexcom, Inc. | Zwitterion surface modifications for continuous sensors |
EP2774538B1 (en) | 2013-03-06 | 2022-05-25 | Roche Diabetes Care GmbH | Process for detecting an analyte using a sensor with Mn2O3 catalyst |
US9737250B2 (en) | 2013-03-15 | 2017-08-22 | Dexcom, Inc. | Membrane for continuous analyte sensors |
WO2017117472A1 (en) | 2015-12-30 | 2017-07-06 | Dexcom, Inc. | Biointerface layer for analyte sensors |
EP3263712A1 (en) * | 2016-06-29 | 2018-01-03 | Roche Diabetes Care GmbH | Galvanically functionalized sensors |
WO2018104522A1 (en) | 2016-12-08 | 2018-06-14 | Roche Diabetes Care Gmbh | Sensor device for determining the concentration of an analyte under in-vivo conditions and process of manufacturing |
EP3363910B1 (en) | 2017-02-17 | 2023-12-06 | Roche Diabetes Care GmbH | Continuous analyte monitoring electrode with crosslinked enzyme |
CA3092192C (en) * | 2018-05-04 | 2023-11-21 | F. Hoffmann-La Roche Ag | Improved diffusion layer for an enzymatic in-vivo sensor |
US20210355312A1 (en) * | 2018-09-27 | 2021-11-18 | l-SENS, INC. | Polymer blend for controlling blood glucose influx, and continuous glucose monitoring biosensor comprising same |
TW202203850A (zh) | 2020-03-13 | 2022-02-01 | 瑞士商赫孚孟拉羅股份公司 | 製備工作電極的方法 |
MX2023000254A (es) | 2020-07-07 | 2023-02-13 | Hoffmann La Roche | Sensor de analito y su elaboracion. |
CN112014448B (zh) * | 2020-09-01 | 2023-02-17 | 深圳硅基传感科技有限公司 | 生物传感器及其制备方法以及生物传感器用的聚合物膜层 |
KR20230106671A (ko) | 2020-11-20 | 2023-07-13 | 에프. 호프만-라 로슈 아게 | 플럭스 제한 중합체 막 |
IL302936A (en) | 2020-11-23 | 2023-07-01 | Hoffmann La Roche | A method for making a working electrode |
EP4000517A1 (en) | 2020-11-23 | 2022-05-25 | Roche Diabetes Care GmbH | Working electrode for an analyte sensor |
EP4251985A1 (en) | 2020-11-24 | 2023-10-04 | F. Hoffmann-La Roche AG | Method for preparing a counter/reference electrode |
EP4130729A1 (en) * | 2021-08-04 | 2023-02-08 | Roche Diabetes Care GmbH | Opening formation in a membrane of a biosensor |
EP4115806A1 (en) | 2021-07-06 | 2023-01-11 | Roche Diabetes Care GmbH | Analyte sensor and method for manufacturing an analyte sensor |
KR20240016431A (ko) | 2021-07-06 | 2024-02-06 | 에프. 호프만-라 로슈 아게 | 분석물 센서 및 분석물 센서를 제조하는 방법 |
EP4140408A1 (en) | 2021-08-30 | 2023-03-01 | Roche Diabetes Care GmbH | Membrane with biodegradable polymer |
EP4151151A1 (en) | 2021-09-21 | 2023-03-22 | F. Hoffmann-La Roche AG | Sensor with varying stiffness |
WO2023122420A1 (en) | 2021-12-24 | 2023-06-29 | Roche Diabetes Care, Inc. | Analyte sensor and method for manufacturing an analyte sensor |
EP4212095A1 (en) | 2022-01-18 | 2023-07-19 | F. Hoffmann-La Roche AG | Analyte sensor and method for manufacturing an analyte sensor |
KR102389269B1 (ko) * | 2022-02-16 | 2022-04-21 | 네메시스 주식회사 | 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서 |
Family Cites Families (38)
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US3542662A (en) | 1967-04-18 | 1970-11-24 | Du Pont | Enzyme electrode |
US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
US4298002A (en) | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
US4418148A (en) * | 1981-11-05 | 1983-11-29 | Miles Laboratories, Inc. | Multilayer enzyme electrode membrane |
WO1992013271A1 (en) | 1991-01-25 | 1992-08-06 | Markwell Medical Institute, Inc. | Implantable biological fluid measuring device |
US5284140A (en) | 1992-02-11 | 1994-02-08 | Eli Lilly And Company | Acrylic copolymer membranes for biosensors |
US5882494A (en) | 1995-03-27 | 1999-03-16 | Minimed, Inc. | Polyurethane/polyurea compositions containing silicone for biosensor membranes |
US5711861A (en) * | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US7657297B2 (en) | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US6258371B1 (en) | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
US6024848A (en) * | 1998-04-15 | 2000-02-15 | International Fuel Cells, Corporation | Electrochemical cell with a porous support plate |
CA2351734A1 (en) * | 1998-11-20 | 2000-06-02 | University Of Connecticut | Generic integrated implantable potentiostat telemetry unit for electrochemical sensors |
WO2003010529A1 (fr) | 2001-07-24 | 2003-02-06 | Nec Corporation | Electrode a enzyme et son procede de production |
US6751491B2 (en) | 2001-09-01 | 2004-06-15 | M Biotech Inc | Analyte measuring biosensor chip using image scanning system |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US20060015083A1 (en) * | 2002-03-11 | 2006-01-19 | Munro Hugh S | Absorbent hydrogels |
US9492111B2 (en) | 2002-04-22 | 2016-11-15 | Medtronic Minimed, Inc. | Methods and materials for stabilizing analyte sensors |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US7232573B1 (en) | 2002-09-26 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Stent coatings containing self-assembled monolayers |
US7569222B2 (en) | 2002-11-18 | 2009-08-04 | Woerly Stephane | Hydrogel membrane composition and use thereof |
WO2007120442A2 (en) | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US7424318B2 (en) | 2003-12-05 | 2008-09-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8309112B2 (en) | 2003-12-24 | 2012-11-13 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same |
US7528204B2 (en) * | 2004-05-17 | 2009-05-05 | The Goodyear Tire & Rubber Company | Hydrogenation and epoxidation of polymers made by controlled polymerization |
US7109271B2 (en) | 2004-07-28 | 2006-09-19 | Lifescan, Inc. | Redox polymers for use in electrochemical-based sensors |
US9011831B2 (en) | 2004-09-30 | 2015-04-21 | Advanced Cardiovascular Systems, Inc. | Methacrylate copolymers for medical devices |
US20060121547A1 (en) | 2004-12-03 | 2006-06-08 | Mcintire Mark | Diffusion layer for an enzyme-based sensor application |
JP4763777B2 (ja) | 2005-05-17 | 2011-08-31 | ラジオメーター・メディカル・アー・ペー・エス | 親水性ポリマーで被覆されたカバー膜層を含む酵素センサー |
US20060275859A1 (en) * | 2005-05-17 | 2006-12-07 | Kjaer Thomas | Enzyme sensor including a water-containing spacer layer |
JP2009540889A (ja) | 2006-06-19 | 2009-11-26 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 電流測定センサおよびその製造方法 |
GB0618789D0 (en) | 2006-09-23 | 2006-11-01 | Sev Trent Services Ltd | Electrolytic cell |
NZ580179A (en) | 2007-03-07 | 2011-06-30 | Echo Therapeutics Inc | Transdermal analyte monitoring systems and methods for analyte detection |
US20100030052A1 (en) | 2008-07-31 | 2010-02-04 | Bommakanti Balasubrahmanya S | Analyte sensors comprising plasticizers |
EP2163190A1 (de) * | 2008-09-11 | 2010-03-17 | Roche Diagnostics GmbH | Elektrodensystem für Messung einer Analytkonzentration in-vivo |
US20120213986A1 (en) * | 2009-08-17 | 2012-08-23 | Carnegie Mellon University | Procedures for development of specific capacitance in carbon structures |
EP2600761A4 (en) | 2010-08-06 | 2014-08-13 | Microchips Inc | MEMBRANE COMPOSITION FOR BIOSENSOR, BIOSENSOR AND METHODS OF MAKING THE SAME |
US20120097554A1 (en) | 2010-10-18 | 2012-04-26 | Medtronic Minimed, Inc. | Analyte sensors comprising electrodes having selected electrochemical and mechanical properties |
-
2012
- 2012-03-27 EP EP12710734.0A patent/EP2697388B1/en not_active Revoked
- 2012-03-27 CN CN201280015837.2A patent/CN103443286B/zh active Active
- 2012-03-27 KR KR1020137025691A patent/KR20130122696A/ko not_active Application Discontinuation
- 2012-03-27 DK DK12710734.0T patent/DK2697388T3/en active
- 2012-03-27 AU AU2012234345A patent/AU2012234345A1/en not_active Abandoned
- 2012-03-27 WO PCT/EP2012/055406 patent/WO2012130841A1/en active Application Filing
- 2012-03-27 SI SI201230233T patent/SI2697388T1/sl unknown
- 2012-03-27 MX MX2013011041A patent/MX2013011041A/es not_active Application Discontinuation
- 2012-03-27 PL PL12710734T patent/PL2697388T3/pl unknown
-
2013
- 2013-03-27 DK DK13712795.7T patent/DK2831263T3/en active
- 2013-03-27 ES ES13712795.7T patent/ES2637811T3/es active Active
- 2013-03-27 ES ES17169444T patent/ES2707347T3/es active Active
- 2013-03-27 BR BR112014021373-9A patent/BR112014021373B1/pt active IP Right Grant
- 2013-09-16 US US14/027,493 patent/US10422765B2/en active Active
-
2014
- 2014-06-09 HK HK14105358.9A patent/HK1191984A1/zh unknown
- 2014-08-19 IL IL234190A patent/IL234190B/en active IP Right Grant
- 2014-09-15 US US14/486,402 patent/US20150005605A1/en not_active Abandoned
-
2015
- 2015-07-30 HK HK15107281.6A patent/HK1206793A1/xx unknown
-
2023
- 2023-04-03 US US18/194,967 patent/US20230258595A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2013011041A (es) | 2013-12-06 |
ES2637811T3 (es) | 2017-10-17 |
US20140018653A1 (en) | 2014-01-16 |
HK1191984A1 (zh) | 2014-08-08 |
BR112014021373B1 (pt) | 2021-08-10 |
DK2697388T3 (en) | 2015-08-31 |
HK1206793A1 (en) | 2016-01-15 |
CN103443286A (zh) | 2013-12-11 |
AU2012234345A1 (en) | 2013-09-05 |
KR20130122696A (ko) | 2013-11-07 |
US20230258595A1 (en) | 2023-08-17 |
EP2697388B1 (en) | 2015-05-20 |
US20150005605A1 (en) | 2015-01-01 |
US10422765B2 (en) | 2019-09-24 |
DK2831263T3 (en) | 2017-09-25 |
PL2697388T3 (pl) | 2015-11-30 |
EP2697388A1 (en) | 2014-02-19 |
IL234190B (en) | 2019-09-26 |
CN103443286B (zh) | 2015-09-23 |
WO2012130841A1 (en) | 2012-10-04 |
SI2697388T1 (sl) | 2015-07-31 |
ES2707347T3 (es) | 2019-04-03 |
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