ES2634421T3 - Uso y composición para tratar la demencia - Google Patents
Uso y composición para tratar la demencia Download PDFInfo
- Publication number
- ES2634421T3 ES2634421T3 ES09726036.8T ES09726036T ES2634421T3 ES 2634421 T3 ES2634421 T3 ES 2634421T3 ES 09726036 T ES09726036 T ES 09726036T ES 2634421 T3 ES2634421 T3 ES 2634421T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically acceptable
- group
- nspacha
- achei
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08005750 | 2008-03-27 | ||
EP08005750 | 2008-03-27 | ||
PCT/US2009/001662 WO2009120277A1 (en) | 2008-03-27 | 2009-03-17 | Use and composition for treating dementia |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2634421T3 true ES2634421T3 (es) | 2017-09-27 |
Family
ID=39535697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09726036.8T Active ES2634421T3 (es) | 2008-03-27 | 2009-03-17 | Uso y composición para tratar la demencia |
Country Status (10)
Country | Link |
---|---|
US (5) | US8404701B2 (ja) |
EP (3) | EP2271218B1 (ja) |
JP (3) | JP5647099B2 (ja) |
AU (1) | AU2009229372C1 (ja) |
CA (1) | CA2718411C (ja) |
DK (1) | DK2271218T3 (ja) |
ES (1) | ES2634421T3 (ja) |
MX (3) | MX2010010460A (ja) |
PL (1) | PL2271218T3 (ja) |
WO (1) | WO2009120277A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8969402B2 (en) | 2006-11-15 | 2015-03-03 | Steven A. Rich | Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases |
WO2011034568A1 (en) | 2009-09-18 | 2011-03-24 | Chase Pharmaceuticals Corporation | Method and composition for treating alzheimer-type dementia |
WO2009120277A1 (en) * | 2008-03-27 | 2009-10-01 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
ES2742728T3 (es) | 2009-07-22 | 2020-02-17 | PureTech Health LLC | Composiciones para el tratamiento de trastornos mejorados por la activación del receptor muscarínico |
JP2011213606A (ja) * | 2010-03-31 | 2011-10-27 | Sawai Pharmaceutical Co Ltd | ドネペジルを含有する固形製剤の製造方法 |
JP2011213695A (ja) * | 2010-04-02 | 2011-10-27 | Taisho Pharm Ind Ltd | ドネペジル塩酸塩含有口腔内速崩壊錠 |
BR122016020433A2 (pt) | 2012-09-05 | 2019-08-27 | Chase Pharmaceuticals Corp | combinação farmacêutica e uso de um nspacha e de um achei e, opcionalmente, de um naaea |
CA2973372A1 (en) | 2015-01-09 | 2016-07-14 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
US10596139B2 (en) | 2015-03-06 | 2020-03-24 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system muscarinic agonist combination |
US10307409B2 (en) * | 2015-03-06 | 2019-06-04 | Chase Pharmaceuticals Corporation | Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system |
WO2016144727A1 (en) * | 2015-03-06 | 2016-09-15 | Chase Pharmaceuticals Corporation | Peripheral-anticholinergic muscarinic agonist combination |
MA43047A (fr) | 2015-06-15 | 2018-08-08 | Qaam Pharmaceuticals Llc | Sels d'acides gras de glycopyrronium et leurs procédés de production |
US20180360845A1 (en) * | 2015-07-20 | 2018-12-20 | Chase Pharmaceuticals Corporation | Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders |
US20180250270A1 (en) | 2015-09-11 | 2018-09-06 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
WO2017147104A1 (en) * | 2016-02-24 | 2017-08-31 | Chase Pharmaceuticals Corporation | Muscarinic m2-antagonist combinations |
US10479706B2 (en) * | 2016-06-03 | 2019-11-19 | Katz Water Tech, Llc | Apparatus, method and system for desalinating water |
US20190269627A1 (en) * | 2016-10-28 | 2019-09-05 | Chase Pharmaceuticals Corporation | Memantine combinations and use |
WO2019201755A1 (en) * | 2018-04-17 | 2019-10-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system for the transdermal administration of solifenacin |
AU2019346626B2 (en) | 2018-09-28 | 2022-06-02 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarinic receptor activation |
US20240024261A1 (en) * | 2020-09-21 | 2024-01-25 | Dr. Raymond Lab Inc | Pharmaceutical composition for improving cognitive ability or enhancing memory |
US12109202B2 (en) | 2021-01-29 | 2024-10-08 | Qaam Pharmaceuticals, Llc | Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB795758A (en) | 1955-08-22 | 1958-05-28 | Pfizer & Co C | Amino esters and the preparation thereof |
US3480626A (en) | 1967-05-18 | 1969-11-25 | Chem Fab Dr R Pfleger | Certain azoniaspironortropine derivatives |
GB1204580A (en) | 1968-10-05 | 1970-09-09 | Aspro Nicholas Ltd | Pharmaceutical dosage forms |
US3576388A (en) | 1968-12-05 | 1971-04-27 | Stauffer Wacker Silicone Corp | Electrical cable |
DD106643A1 (ja) | 1973-07-12 | 1974-06-20 | ||
US4965074A (en) | 1985-03-05 | 1990-10-23 | Ciba-Geigy Corporation | Method of treating memory impairment |
US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
US4798841A (en) | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
GB8717446D0 (en) | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
US5382600A (en) | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
US4937239A (en) | 1989-02-13 | 1990-06-26 | Warner-Lambert Company | Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents |
US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
GB9612710D0 (en) | 1996-06-18 | 1996-08-21 | Pfizer Ltd | Method of treatment |
ES2255170T3 (es) | 1997-07-09 | 2006-06-16 | Axonyx | Inhibidores de butirilcolinesterasa altamente selectivos para el tratamiento y diagnostico de demencias y de la enfermedad de alzheimer. |
EP0976404A3 (en) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
CA2310926C (en) | 2000-04-03 | 2002-10-15 | Janssen Pharmaceutica N.V. | A use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease |
AU2002253929A1 (en) * | 2001-02-08 | 2002-09-24 | Schering Corporation | Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders |
US8216609B2 (en) * | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
US7427280B2 (en) * | 2002-09-06 | 2008-09-23 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues |
US6974820B2 (en) | 2002-11-06 | 2005-12-13 | Bridge Pharma, Inc. | Methods for treating urinary incontinence and other disorders using trospium |
CN1520818A (zh) | 2003-02-09 | 2004-08-18 | 山东绿叶天然药物研究开发有限公司 | 治疗老年性痴呆的胆碱酯酶抑制剂药物组合物 |
US8299062B2 (en) | 2003-09-17 | 2012-10-30 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
CA2552558A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
BRPI0507905A (pt) | 2004-02-20 | 2007-07-10 | Novartis Ag | uso de compostos orgánicos |
AR051950A1 (es) | 2004-11-10 | 2007-02-21 | Osmotica Pharmaceutical Argent | Comprimido multicapa con capas que se separan |
US8481565B2 (en) | 2004-12-27 | 2013-07-09 | Eisai R&D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
US7390816B2 (en) * | 2005-06-21 | 2008-06-24 | Bridge Pharma, Inc. | Methods for treating urinary incontinence in patients suffering from memory disorders |
US20070004766A1 (en) | 2005-07-01 | 2007-01-04 | Aberg A K G | Methods for relaxation of smooth muscle contractions using Trospium |
US20070224259A1 (en) | 2005-09-21 | 2007-09-27 | Gupta Anil K | Anti-inflammatory pharmaceutical composition |
PT1933809E (pt) | 2005-10-11 | 2012-04-26 | Yissum Res Dev Co | Composições para administração por via nasal |
MX2008013539A (es) * | 2006-04-21 | 2008-10-29 | Wyeth Corp | Produccion de intermediarios de amino alcohol quiralmente puros, derivados de los mismos, y usos de los mismos. |
AU2007294968A1 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
US20080090808A1 (en) | 2006-10-17 | 2008-04-17 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
US8097633B2 (en) * | 2006-11-15 | 2012-01-17 | Rich Steven A | Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium |
WO2011034568A1 (en) * | 2009-09-18 | 2011-03-24 | Chase Pharmaceuticals Corporation | Method and composition for treating alzheimer-type dementia |
WO2009120277A1 (en) * | 2008-03-27 | 2009-10-01 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
-
2009
- 2009-03-17 WO PCT/US2009/001662 patent/WO2009120277A1/en active Application Filing
- 2009-03-17 CA CA2718411A patent/CA2718411C/en active Active
- 2009-03-17 EP EP09726036.8A patent/EP2271218B1/en not_active Revoked
- 2009-03-17 ES ES09726036.8T patent/ES2634421T3/es active Active
- 2009-03-17 MX MX2010010460A patent/MX2010010460A/es active IP Right Grant
- 2009-03-17 MX MX2013009019A patent/MX344177B/es unknown
- 2009-03-17 EP EP17150365.9A patent/EP3178477A1/en not_active Withdrawn
- 2009-03-17 AU AU2009229372A patent/AU2009229372C1/en not_active Ceased
- 2009-03-17 DK DK09726036.8T patent/DK2271218T3/en active
- 2009-03-17 EP EP22177194.2A patent/EP4088717A1/en not_active Withdrawn
- 2009-03-17 MX MX2014004035A patent/MX347901B/es unknown
- 2009-03-17 US US12/934,140 patent/US8404701B2/en active Active
- 2009-03-17 JP JP2011501792A patent/JP5647099B2/ja not_active Expired - Fee Related
- 2009-03-17 PL PL09726036T patent/PL2271218T3/pl unknown
-
2013
- 2013-02-12 US US13/765,240 patent/US20130158012A1/en not_active Abandoned
-
2014
- 2014-01-14 JP JP2014004320A patent/JP2014114295A/ja active Pending
- 2014-05-29 US US14/290,123 patent/US9044472B2/en active Active
-
2015
- 2015-04-27 US US14/696,861 patent/US20150224096A1/en not_active Abandoned
-
2016
- 2016-04-11 JP JP2016078787A patent/JP6427522B2/ja not_active Expired - Fee Related
-
2018
- 2018-11-21 US US16/198,517 patent/US20190091214A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2009229372B2 (en) | 2014-09-25 |
EP3178477A1 (en) | 2017-06-14 |
WO2009120277A1 (en) | 2009-10-01 |
MX344177B (es) | 2016-12-08 |
US8404701B2 (en) | 2013-03-26 |
JP2014114295A (ja) | 2014-06-26 |
AU2009229372C1 (en) | 2017-02-02 |
JP2016179980A (ja) | 2016-10-13 |
US9044472B2 (en) | 2015-06-02 |
MX2010010460A (es) | 2010-12-15 |
CA2718411A1 (en) | 2009-10-01 |
US20150224096A1 (en) | 2015-08-13 |
JP6427522B2 (ja) | 2018-11-21 |
AU2009229372A1 (en) | 2009-10-01 |
PL2271218T3 (pl) | 2017-10-31 |
MX347901B (es) | 2017-05-18 |
JP5647099B2 (ja) | 2014-12-24 |
DK2271218T3 (en) | 2017-09-11 |
EP2271218B1 (en) | 2017-05-24 |
EP4088717A1 (en) | 2022-11-16 |
CA2718411C (en) | 2016-02-16 |
US20140275036A1 (en) | 2014-09-18 |
EP2271218A1 (en) | 2011-01-12 |
EP2271218A4 (en) | 2011-05-18 |
US20190091214A1 (en) | 2019-03-28 |
US20130158012A1 (en) | 2013-06-20 |
JP2011518776A (ja) | 2011-06-30 |
US20110021503A1 (en) | 2011-01-27 |
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