ES261826A1 - Procedimiento para la obtenciën de nuevas piperacinas n,n-sustituidas - Google Patents

Procedimiento para la obtenciën de nuevas piperacinas n,n-sustituidas

Info

Publication number
ES261826A1
ES261826A1 ES0261826A ES261826A ES261826A1 ES 261826 A1 ES261826 A1 ES 261826A1 ES 0261826 A ES0261826 A ES 0261826A ES 261826 A ES261826 A ES 261826A ES 261826 A1 ES261826 A1 ES 261826A1
Authority
ES
Spain
Prior art keywords
compounds
compound
general formula
reacting
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0261826A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Publication of ES261826A1 publication Critical patent/ES261826A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

Procedimiento para la obtención de nuevas piperacinas N,N-disubstituidas, de la fórmula **FIGURA** en la que R1 representa un átomo de hidrógeno o un radical trifluorometilo, y R2, en posición meta o para, representa un átomo de hidrógeno o un radical nitro, amino, mono- o dialcohilamino, mono- o dihidroxialcohilamino, acilamido alifático o N-alcohilacilamido así como sus sales de adición con los ácidos, caracterizándose porque se hace reaccionar en un disolvente inerte, en presencia de un aceptador de ácido.
ES0261826A 1959-10-20 1960-10-19 Procedimiento para la obtenciën de nuevas piperacinas n,n-sustituidas Expired ES261826A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35550/59A GB948766A (en) 1959-10-20 1959-10-20 Trifluoromethylphenylpiperazine derivatives

Publications (1)

Publication Number Publication Date
ES261826A1 true ES261826A1 (es) 1961-01-16

Family

ID=10378977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0261826A Expired ES261826A1 (es) 1959-10-20 1960-10-19 Procedimiento para la obtenciën de nuevas piperacinas n,n-sustituidas

Country Status (6)

Country Link
US (1) US3170926A (es)
CH (4) CH405320A (es)
ES (1) ES261826A1 (es)
FR (2) FR1300728A (es)
GB (1) GB948766A (es)
LU (1) LU39286A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8550003B2 (en) 2010-04-26 2013-10-08 Rodney Neil Cameron Pyrotechnic device

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189553B (de) * 1962-08-09 1965-03-25 Degussa Verfahren zur Herstellung von racemischen und optisch aktiven Piperazinderivaten
US3277094A (en) * 1965-05-10 1966-10-04 Ciba Geigy Corp Piperazine derivatives
US3954763A (en) * 1972-04-10 1976-05-04 Synthelabo N-Metatrifluoromethylthiophenyl-piperazine
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives
FR2173869B1 (es) * 1972-04-13 1975-12-26 Cerm Cent Europ Rech Mauvernay
CS164487B1 (es) * 1972-12-22 1975-11-07
GB1560271A (en) * 1977-01-14 1980-02-06 Joullie International Sa Therapeutically useful m-trifluoromethylphenylpiperazine derivatives
US4267328A (en) * 1978-08-01 1981-05-12 Synthelabo 1-Phenylpiperazines
US4713382A (en) * 1985-05-30 1987-12-15 Syntex (U.S.A.) Inc. N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US4891375A (en) * 1988-01-13 1990-01-02 Pfizer Inc. Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
US5451622A (en) * 1992-09-30 1995-09-19 Minnesota Mining And Manufacturing Company Composition comprising thermoplastic polymer and fluorochemical piperazine compound
US6864262B2 (en) * 2000-11-29 2005-03-08 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof
JP6173693B2 (ja) * 2010-02-24 2017-08-02 リサーチ・トライアングル・インスティチュート アリールピペラジンオピオイド受容体アンタゴニスト

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3068222A (en) * 1962-12-11 Trifluoromethyl substituted dibenzxze-
US3070606A (en) * 1962-12-25 Xchxn
US2647121A (en) * 1951-02-02 1953-07-28 Ruth P Jacoby Diamine-bis-acetamides
US2834782A (en) * 1955-07-14 1958-05-13 Endo Lab Monocalcium monopiperazine salt of ethylenediaminetetracetic acid
US2939816A (en) * 1956-03-19 1960-06-07 Harold L Trexler Insect deterrents containing staphisagria
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
US2997474A (en) * 1959-10-12 1961-08-22 Paul A J Janssen 1-aryl-omega-(4-arylpiperazine) alkanols
US2990327A (en) * 1960-07-14 1961-06-27 Synergistics Inc Composition and method for treating biliary dyskinesia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8550003B2 (en) 2010-04-26 2013-10-08 Rodney Neil Cameron Pyrotechnic device

Also Published As

Publication number Publication date
GB948766A (en) 1964-02-05
CH405320A (fr) 1966-01-15
FR1300728A (es) 1962-07-02
US3170926A (en) 1965-02-23
CH406228A (fr) 1966-01-31
CH398612A (fr) 1966-03-15
FR746M (es) 1961-08-04
LU39286A1 (es) 1960-12-15
CH389622A (fr) 1965-03-31

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