ES2603640T3 - Un proceso para inhibidor selectivo de ciclooxigenasa-2 - Google Patents

Un proceso para inhibidor selectivo de ciclooxigenasa-2 Download PDF

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Publication number
ES2603640T3
ES2603640T3 ES11817540.5T ES11817540T ES2603640T3 ES 2603640 T3 ES2603640 T3 ES 2603640T3 ES 11817540 T ES11817540 T ES 11817540T ES 2603640 T3 ES2603640 T3 ES 2603640T3
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ES
Spain
Prior art keywords
methyl
inhibitor
selective cyclooxygenase
tri
formula
Prior art date
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Active
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ES11817540.5T
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English (en)
Inventor
Dharmesh Mahendra Shah
Sanjay Amratlal Solanki
Viral Narendra Jariwala
Ashok Vasantray Vyas
Ashokkumar Bhikhubhai Mistry
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Virdev Intermediates PVT Ltd
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Virdev Intermediates PVT Ltd
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Publication of ES2603640T3 publication Critical patent/ES2603640T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un proceso para la preparación de etoricoxib, que comprende someter la 5-cloro-3-(4- metitio)fenil-2-(2-metil-5- piridinil)piridina (IV) a oxidación en presencia de un catalizador de la oxidación y de un catalizador de transferencia de fase, y este último se selecciona de un grupo que comprende cloruro de metil-tri-n-octil-amonio, cloruro de metil-tri-n-butil-amonio, cloruro de bencetonio, y cloruro de metil-bencetonio, a fin de obtener el etoricoxib de la fórmula-(I).**Fórmula**

Description

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Claims (1)

  1. imagen1
    imagen2
ES11817540.5T 2010-11-15 2011-11-15 Un proceso para inhibidor selectivo de ciclooxigenasa-2 Active ES2603640T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
INMU31212010 2010-11-15
IN3121MU2010 2010-11-15
PCT/IN2011/000791 WO2012066570A2 (en) 2010-11-15 2011-11-15 A process for cyclooxygenase-2 selective inhibitor

Publications (1)

Publication Number Publication Date
ES2603640T3 true ES2603640T3 (es) 2017-02-28

Family

ID=45607325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11817540.5T Active ES2603640T3 (es) 2010-11-15 2011-11-15 Un proceso para inhibidor selectivo de ciclooxigenasa-2

Country Status (9)

Country Link
US (1) US8841457B2 (es)
EP (1) EP2649049B1 (es)
BR (1) BR112013012008B1 (es)
CA (1) CA2817939A1 (es)
ES (1) ES2603640T3 (es)
MY (1) MY163379A (es)
RU (1) RU2591848C2 (es)
UA (1) UA114594C2 (es)
WO (1) WO2012066570A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204803A (zh) * 2012-01-13 2013-07-17 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 用于合成依托考昔的方法
GR1007973B (el) * 2012-06-26 2013-09-12 Φαρματεν Αβεε, Νεα ν-οξοιμινο παραγωγα ως ενδιαμεσα μιας βελτιωμενης μεθοδου παρασκευης 2,3-διαρυλο-5-υποκατεστημενων πυριδινων
ITMI20121947A1 (it) * 2012-11-15 2014-05-16 Erregierre Spa Processo di sintesi di un intermedio nella produzione di etoricoxib
CN104045596B (zh) * 2014-06-27 2017-03-22 成都克莱蒙医药科技有限公司 制备依托考昔中间体1‑(6‑甲基吡啶‑3‑基)‑2‑[4‑(甲磺酰基)苯基]乙酮的方法
CN108689917A (zh) * 2017-04-08 2018-10-23 深圳市华先医药科技有限公司 一种依托考昔中间体连续流生产工艺
CN107056691B (zh) * 2017-06-21 2020-03-10 四川尚锐生物医药有限公司 一种制备依托考昔晶型v的方法
CN109954396A (zh) * 2019-03-22 2019-07-02 南通大学 一种畜禽养殖用的杀菌消毒除臭剂
CN110143915A (zh) * 2019-06-03 2019-08-20 蚌埠学院 一种依托考昔与对甲苯磺酸形成盐的新晶型及制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
TW492959B (en) * 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
US6040450A (en) * 1997-09-25 2000-03-21 Merck & Co., Inc. Process for making diaryl pyridines useful as cox-2-inhibitors
AR015938A1 (es) * 1997-09-25 2001-05-30 Merck Sharp & Dohme Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario
CN1178658C (zh) 1998-04-24 2004-12-08 麦克公司 合成环加氧酶-2抑制剂的方法
US6566527B1 (en) * 1999-07-27 2003-05-20 Merck & Co., Inc. Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone
ES2214130B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 2-3'-bipiridinas.
WO2005120584A2 (en) * 2004-06-03 2005-12-22 The Trustees Of Columbia University In The City Of New York Radiolabeled arylsulfonyl compounds and uses thereof
PL2401253T3 (pl) 2009-02-27 2016-05-31 Cadila Healthcare Ltd Sposób otrzymywania etorykoksybu

Also Published As

Publication number Publication date
WO2012066570A3 (en) 2012-07-12
US20130245272A1 (en) 2013-09-19
RU2013127262A (ru) 2014-12-27
BR112013012008B1 (pt) 2021-10-13
BR112013012008A2 (pt) 2017-04-11
MY163379A (en) 2017-09-15
EP2649049A2 (en) 2013-10-16
UA114594C2 (uk) 2017-07-10
US8841457B2 (en) 2014-09-23
EP2649049B1 (en) 2016-08-24
WO2012066570A2 (en) 2012-05-24
CA2817939A1 (en) 2012-05-24
RU2591848C2 (ru) 2016-07-20

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