BR112013012008A2 - um processo para inibidor seletivo da ciclo-oxigenase-2 - Google Patents
um processo para inibidor seletivo da ciclo-oxigenase-2Info
- Publication number
- BR112013012008A2 BR112013012008A2 BR112013012008A BR112013012008A BR112013012008A2 BR 112013012008 A2 BR112013012008 A2 BR 112013012008A2 BR 112013012008 A BR112013012008 A BR 112013012008A BR 112013012008 A BR112013012008 A BR 112013012008A BR 112013012008 A2 BR112013012008 A2 BR 112013012008A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitor
- selective cyclooxygenase
- cyclooxygenase
- selective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3121/MUM/2010 | 2010-11-15 | ||
| IN3121MU2010 | 2010-11-15 | ||
| PCT/IN2011/000791 WO2012066570A2 (en) | 2010-11-15 | 2011-11-15 | A process for cyclooxygenase-2 selective inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013012008A2 true BR112013012008A2 (pt) | 2017-04-11 |
| BR112013012008B1 BR112013012008B1 (pt) | 2021-10-13 |
Family
ID=45607325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013012008-8A BR112013012008B1 (pt) | 2010-11-15 | 2011-11-15 | Processo para o inibidor seletivo da ciclo-oxigenase-2 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8841457B2 (pt) |
| EP (1) | EP2649049B1 (pt) |
| BR (1) | BR112013012008B1 (pt) |
| CA (1) | CA2817939A1 (pt) |
| ES (1) | ES2603640T3 (pt) |
| MY (1) | MY163379A (pt) |
| RU (1) | RU2591848C2 (pt) |
| UA (1) | UA114594C2 (pt) |
| WO (1) | WO2012066570A2 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103204803A (zh) * | 2012-01-13 | 2013-07-17 | 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 | 用于合成依托考昔的方法 |
| GR1007973B (el) * | 2012-06-26 | 2013-09-12 | Φαρματεν Αβεε, | Νεα ν-οξοιμινο παραγωγα ως ενδιαμεσα μιας βελτιωμενης μεθοδου παρασκευης 2,3-διαρυλο-5-υποκατεστημενων πυριδινων |
| ITMI20121947A1 (it) * | 2012-11-15 | 2014-05-16 | Erregierre Spa | Processo di sintesi di un intermedio nella produzione di etoricoxib |
| CN104045596B (zh) * | 2014-06-27 | 2017-03-22 | 成都克莱蒙医药科技有限公司 | 制备依托考昔中间体1‑(6‑甲基吡啶‑3‑基)‑2‑[4‑(甲磺酰基)苯基]乙酮的方法 |
| CN108689917A (zh) * | 2017-04-08 | 2018-10-23 | 深圳市华先医药科技有限公司 | 一种依托考昔中间体连续流生产工艺 |
| CN107056691B (zh) * | 2017-06-21 | 2020-03-10 | 四川尚锐生物医药有限公司 | 一种制备依托考昔晶型v的方法 |
| CN109954396A (zh) * | 2019-03-22 | 2019-07-02 | 南通大学 | 一种畜禽养殖用的杀菌消毒除臭剂 |
| CN110143915A (zh) * | 2019-06-03 | 2019-08-20 | 蚌埠学院 | 一种依托考昔与对甲苯磺酸形成盐的新晶型及制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
| US6040450A (en) * | 1997-09-25 | 2000-03-21 | Merck & Co., Inc. | Process for making diaryl pyridines useful as cox-2-inhibitors |
| AR015938A1 (es) * | 1997-09-25 | 2001-05-30 | Merck Sharp & Dohme | Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario |
| EA002975B1 (ru) | 1998-04-24 | 2002-12-26 | Мерк Энд Ко., Инк. | Способ синтеза ингибиторов циклооксигеназы-2 |
| US6566527B1 (en) * | 1999-07-27 | 2003-05-20 | Merck & Co., Inc. | Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| WO2005120584A2 (en) | 2004-06-03 | 2005-12-22 | The Trustees Of Columbia University In The City Of New York | Radiolabeled arylsulfonyl compounds and uses thereof |
| PL2401253T3 (pl) | 2009-02-27 | 2016-05-31 | Cadila Healthcare Ltd | Sposób otrzymywania etorykoksybu |
-
2011
- 2011-11-15 CA CA2817939A patent/CA2817939A1/en not_active Abandoned
- 2011-11-15 MY MYPI2013700782A patent/MY163379A/en unknown
- 2011-11-15 ES ES11817540.5T patent/ES2603640T3/es active Active
- 2011-11-15 BR BR112013012008-8A patent/BR112013012008B1/pt not_active IP Right Cessation
- 2011-11-15 RU RU2013127262/04A patent/RU2591848C2/ru active IP Right Revival
- 2011-11-15 UA UAA201307457A patent/UA114594C2/uk unknown
- 2011-11-15 WO PCT/IN2011/000791 patent/WO2012066570A2/en active Application Filing
- 2011-11-15 EP EP11817540.5A patent/EP2649049B1/en not_active Not-in-force
- 2011-11-15 US US13/885,522 patent/US8841457B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012066570A3 (en) | 2012-07-12 |
| US8841457B2 (en) | 2014-09-23 |
| BR112013012008B1 (pt) | 2021-10-13 |
| CA2817939A1 (en) | 2012-05-24 |
| MY163379A (en) | 2017-09-15 |
| RU2013127262A (ru) | 2014-12-27 |
| ES2603640T3 (es) | 2017-02-28 |
| RU2591848C2 (ru) | 2016-07-20 |
| EP2649049A2 (en) | 2013-10-16 |
| UA114594C2 (uk) | 2017-07-10 |
| US20130245272A1 (en) | 2013-09-19 |
| WO2012066570A2 (en) | 2012-05-24 |
| EP2649049B1 (en) | 2016-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 213/61 Ipc: C07D 213/61 (2006.01), A61P 29/00 (2006.01), A61P |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/11/2011, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 11A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2696 DE 06-09-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |