ES2594498T3 - Un dispositivo de electroporación cutánea tolerable y mínimamente invasivo - Google Patents

Un dispositivo de electroporación cutánea tolerable y mínimamente invasivo Download PDF

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Publication number
ES2594498T3
ES2594498T3 ES11751208.7T ES11751208T ES2594498T3 ES 2594498 T3 ES2594498 T3 ES 2594498T3 ES 11751208 T ES11751208 T ES 11751208T ES 2594498 T3 ES2594498 T3 ES 2594498T3
Authority
ES
Spain
Prior art keywords
layers
electrodes
tissue
stratum corneum
electroporation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11751208.7T
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English (en)
Spanish (es)
Inventor
Kate Broderick
Jay Mccoy
Stephen V Kemmerrer
Feng Lin
Rune Kjeken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inovio Pharmaceuticals Inc
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2594498T3 publication Critical patent/ES2594498T3/es
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES11751208.7T 2010-03-01 2011-03-01 Un dispositivo de electroporación cutánea tolerable y mínimamente invasivo Active ES2594498T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30942210P 2010-03-01 2010-03-01
US309422P 2010-03-01
PCT/US2011/026701 WO2011109406A1 (en) 2010-03-01 2011-03-01 A tolerable and minimally invasive skin electroporation device

Publications (1)

Publication Number Publication Date
ES2594498T3 true ES2594498T3 (es) 2016-12-20

Family

ID=44542539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11751208.7T Active ES2594498T3 (es) 2010-03-01 2011-03-01 Un dispositivo de electroporación cutánea tolerable y mínimamente invasivo

Country Status (15)

Country Link
US (2) US11565107B2 (enExample)
EP (1) EP2542300B1 (enExample)
JP (1) JP5706451B2 (enExample)
KR (1) KR101872408B1 (enExample)
CN (1) CN102905755B (enExample)
AU (1) AU2011223753B2 (enExample)
BR (1) BR112012021805A2 (enExample)
CA (1) CA2789736A1 (enExample)
DK (1) DK2542300T3 (enExample)
EA (1) EA025705B1 (enExample)
ES (1) ES2594498T3 (enExample)
MX (1) MX2012009986A (enExample)
PL (1) PL2542300T3 (enExample)
PT (1) PT2542300T (enExample)
WO (1) WO2011109406A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9913978B2 (en) 2011-06-28 2018-03-13 Kate Broderick Miniminally invasive dermal electroporation device
AU2015203882C1 (en) * 2011-06-28 2017-09-21 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
EP3010582B1 (en) 2013-06-21 2021-04-28 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
CN104689478A (zh) * 2013-12-09 2015-06-10 深圳市瑞吉思科技有限公司 细胞再生仪
CN103861202B (zh) * 2014-03-18 2016-06-01 苏州壹达生物科技有限公司 一种利用空心电极针电穿孔给药的装置
CA2981474A1 (en) * 2015-03-31 2016-10-06 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
CA3009348A1 (en) 2015-12-30 2017-07-06 Inovio Pharmaceuticals, Inc. Electroporation device with detachable needle array with lock-out system
WO2018064463A1 (en) * 2016-09-30 2018-04-05 University Of Florida Research Foundation, Inc. Systems and methods including porous membrane for low-voltage continuous cell electroporation
CN107890608A (zh) * 2017-12-01 2018-04-10 王嘉浩 淋巴细胞增升仪
EP3880295B1 (en) * 2019-02-04 2023-07-12 Rutgers, the State University of New Jersey Device for tissue electrotransfer using a microelectrode
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
BR102019013578A2 (pt) * 2019-06-28 2021-01-05 Eqt Equipamentos E Tecnologia Ltda. Ponta aplicadora de eletroporação para procedimento de eletroquimioterapia
KR102576604B1 (ko) 2021-02-16 2023-09-08 주식회사 밀알 의료용 정밀 약물주입 및 전기천공 융합 전극
KR20220159203A (ko) 2021-05-25 2022-12-02 주식회사 밀알 의료용 정밀 약물주입 및 전기천공 융합 전극

Family Cites Families (22)

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US3994287A (en) * 1974-07-01 1976-11-30 Centre De Recherche Industrielle Du Quebec Trocar
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
ATE241405T1 (de) * 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
CA2285056C (en) 1997-04-03 2004-12-14 Iacob Mathiesen Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
CN1261807A (zh) 1997-06-30 2000-08-02 罗纳-布朗克罗莱尔股份有限公司 向横纹肌中转移核酸的改进方法和用于实施该方法的组合
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
TW368420B (en) * 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
ATE256484T1 (de) * 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US20070016268A1 (en) 2000-01-07 2007-01-18 John Carter Percutaneous electrode array
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
AU2003226605A1 (en) * 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
JP5059786B2 (ja) * 2006-02-11 2012-10-31 ジェネトロニクス，インコーポレイティド 単針生体内エレクトロポレーションのための装置および方法
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
US20080287866A1 (en) * 2007-01-31 2008-11-20 Adam Heller Methods and compositions for the treatment of pain

Also Published As

Publication number Publication date
KR101872408B1 (ko) 2018-06-28
CN102905755A (zh) 2013-01-30
EP2542300A1 (en) 2013-01-09
JP2013521058A (ja) 2013-06-10
PT2542300T (pt) 2016-11-14
WO2011109406A1 (en) 2011-09-09
HK1181339A1 (zh) 2013-11-08
AU2011223753B2 (en) 2014-06-26
MX2012009986A (es) 2012-11-21
AU2011223753A1 (en) 2012-09-13
CN102905755B (zh) 2016-03-09
EA025705B1 (ru) 2017-01-30
DK2542300T3 (en) 2016-11-28
EA201201203A1 (ru) 2013-04-30
JP5706451B2 (ja) 2015-04-22
US12491361B2 (en) 2025-12-09
EP2542300B1 (en) 2016-08-10
US20130066296A1 (en) 2013-03-14
US11565107B2 (en) 2023-01-31
CA2789736A1 (en) 2011-09-09
PL2542300T3 (pl) 2017-06-30
KR20130020662A (ko) 2013-02-27
US20230145532A1 (en) 2023-05-11
BR112012021805A2 (pt) 2016-05-17
EP2542300A4 (en) 2013-11-13

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