ES2590229B1 - PROCEDURE FOR THE PREPARATION OF A VENOPROTECTOR CREAM WITH SOLAR PROTECTOR AND COMPOSITIONS OBTAINED BY THIS PROCEDURE - Google Patents

Abstract

The present invention discloses a method and a cream composition of the venoprotective action to the user of the product, combining the sunscreen effect with the venoprotective effect of the compounds added to the basic formulation. The compositions of the present invention in addition to Pinus pinaster contain, sunscreens, emulsifying agents, thickening agents, pH regulating agents, moisturizing agents and perfumes.

Description

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DESCRIPTION

PROCEDURE FOR THE PREPARATION OF A VENOPROTECTING CREAM WITH SOLAR PROTECTOR AND COMPOSITIONS OBTAINED BY THIS PROCEDURE

OBJECT OF THE INVENTION

The present invention discloses a preparation procedure for a cream for external use and the compositions obtained by this procedure that allow protection against chronic venous disease and which also acts as a sunscreen.

BACKGROUND OF THE INVENTION

In today's world, varicose veins problems are very frequent in people, with the consequent discomfort that this entails for those affected, in their physical state, in addition to the limitations that it gives rise to, in many cases restricting the activity, even impeding for the development of certain functions of work, sport, etc., performed outdoors and in the presence of sun. The limitation to solar exposure is one of the pillars of the recommendations given to patients with chronic venous disease. However, not all patients with chronic venous disease can limit or cancel sun exposure, whether for work, social, family or any other reason.

There are currently in the market a variety of topical products for the treatment of varicose veins, but all of them suffer from a characteristic problem. On the one hand, such products are made from chemical compounds that are generally aggressive to a greater or lesser extent to the skin, especially when it is, as is often the case, prolonged treatments, and harmless that at first sight such chemical compounds may seem.

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Patent application publication number ES2087036 discloses a gel for relieving varicose vein symptoms in patients, wherein said gel comprises a mixture of Witch hazel Carbopol, Cremalys, Harpagofito, Katon, white hawthorn, dandelion, horse chestnut The invention It also affects the procedure for obtaining this anti-varicose gel, a procedure that is carried out in a ford and with very rapid agitation, establishing the following phases or operational stages in it: In a first stage the water is added to the ford container and agitation. the katon CG and carbopol. It is stirred rapidly for a time of the order of one hour, then adding triethanolamine and isopropyl alcohol, proceeding to a new stirring for a time of the order of ten minutes, after which the process is stopped and the natural extracts are introduced Hawthorn, dandelion, harpagofito, witch hazel and horse chestnut, together with the cremalys as flavoring, proceeding again to another stirring, also maintaining the ford, of the order of ten minutes, to finally proceed to its packaging.

The process is carried out at room temperature, with a resulting pH between 5 and 6 units. Although this product, due to its active substance, can be used to alleviate varicose veins problems, it is totally contraindicated to be used outdoors, since if you do not have enough protection, exposure to UVB rays can cause burns and redness. It also encourages the skin to produce melanin, the pigment that the body uses to protect itself. A tan is a sign of melanin production to counteract damage. The sun is important for our health and helps us produce vitamin D. However, we have to enjoy it in moderation and avoid long exposure. Sun exposure has been linked to cancers and aging.

We use sunscreens with care and consideration in our products. They are combined with fresh and natural ingredients, such as seaweed, green tea, witch hazel and hypericum, natural softening oils and fresh fruits to revitalize delicately. The skin is sought to respond to damage with the help of these wonderful ingredients.

Well, to alleviate as much as possible those inconvenience and harmful consequences

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of the varicose veins, in accordance with the object of the present invention, a topical product is proposed, with a toning action, which is very advantageous to reduce the aforementioned effects of the varicose veins and, at the same time, allows protection from the sun when activities are carried out in full light day.

The present invention offers a venotonic and venoprotective action to the user of the product, combining the sunscreen effect with the venoprotective effect of the compounds added to the basic formulation.

DESCRIPTION OF THE INVENTION

The procedure presents the obtaining of a new composition on the basis of which a venoprotective effect associated with protection against ultraviolet rays is achieved. Therefore, the protective action against skin cancer, photo aging and sunburn are combined with the protective and therapeutic action on the venous wall.

The extracts that cause the beneficial effects on the venous wall are the following:

Ruscus aculeatus: an active substance is concentrated in its root, ruscogenin, which has venotonic action, activates microcirculation and facilitates lymphatic and circulatory drainage. It is used against hemorrhoids and varicose veins, thanks to its components that are vasoconstrictor and anti-inflammatory. It is applied externally and its rhizome, root and leaves are used. It also reduces cellulite and by containing rutoside, helps varicose and tired legs; It also helps against phlebitis and improves circulation

Centella asiatica: acts protecting vascular tissue. Stimulates collagen biosynthesis. As stated in the WHO monograph and the information issued

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by the EMEA (European Medicines Agency), the fresh plant, its extracts and tinctures have been used topically to treat varicose veins and dermatitis. Its efficacy has been clinically proven topically for the treatment of wounds, burns and ulcers and the prevention of keloid and hypertrophic scars and for accelerating healing, particularly in cases of chronic post-surgical trauma. The scientific literature that refers to its traditional use supports the efficacy of Centella asiatica in the treatment of ulcers and venous disorders (venous hypertension).

Aesculus hippocastanum or Castano de indias: It is a venous or vasoprotective tonic that manages to reduce the viscosity of the blood, making it more liquid, reduces the sedimentation time causing a decongestion of the blood vessels and increases the capillary resistance thanks to the action of the escina And the sculpted. Escina also has anti-inflammatory properties and controls the permeability of the vessels (antiedematous activity). Together, it performs an antivitamic activity P. Saponosides facilitate the diffusion of other active substances when applied topically. It can be applied as an external ointment because it reduces the diameter of the veins, reducing inflammation caused by varicose veins, phlebitis, venous insufficiency and other circulatory disorders (such as edema, ecchymosis, rosacea cuperosis).

Pinus pinaster: Contains the active substance leucocyanidol that has properties such as antihemorrhagic and vitamin P, controlling permeability and increasing capillary resistance. The tannins are astringent (antidiarrheal, local hemostatic, healing). Indicated for the treatment of varicose veins, and capillary fragility.

The compositions of the present invention in addition to the above extracts contain, sunscreens, emulsifying agents, thickening agents, pH regulating agents, moisturizing agents and perfumes. In the examples of the preferred embodiment, two compositions are revealed depending on the sun protection that the user requires.

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PREFERRED EMBODIMENT OF THE INVENTION

The present invention starts from the combination of extracts for the treatment of varicose veins, and capillary fragility or an extract selected from the group formed by Pinus pinaster, Ruscus aculeatus, Centella asiatica and Castano de indias, in addition to a series of components that They allow sun protection, some of them used as sunscreens such as Octocrilene which is an organic compound used as a basic ingredient in sunscreens and cosmetics. The extended conjugation of the acrylate portion of the molecule absorbs UVB and short wave UVA ( ultraviolet) rays with wavelengths from 280 to 320 nm, the protection of the skin from direct DNA damage. The ethylhexanol portion is a fatty alcohol, with properties such as water resistant and paraoleous emollients. This organic compound can penetrate the skin, where it acts as a photosensitizer.

The composition also contains Ethylhexyl methoxycinnamate, which is used to absorb UVA rays in sunscreen products. Decades have been used safely in cosmetics and sunscreens that together with the Butyl Methoxydibenzoylmethane protects against UV rays in a very effective way, the composition also contains titanium dioxide which is a light sensitive semiconductor that absorbs electromagnetic radiation near the UV region . Titanium dioxide pigments are also used as UV absorbers in tanning products. The composition also presents VP / Copolymer 2 of Eicosano also known as 2-pyrrolidinone, 1-ethhenyl- vinyl, 1-eicosenne which is a_Form forming agent used in water-resistant sunscreen products. It helps the sunscreen adhere better to the skin and avoid scrolling through the presence of water.

In order to make the compositions of the present invention, it is also necessary to use emulsifiers that allow to sustain the mixture of two others that cannot be mixed, such as oils and water. As you know an emulsion is a mixture formed by two immiscible liquids that are found

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evenly distributed in each other in the form of small drops stabilized by a third component, the emulsifying agent.

So it is necessary that the composition should also contain emulsifiers that are applicable in the pharmaceutical and cosmetic industry, such as glycerin stearate commonly called stearine, which can be extracted from both animal fat and vegetable fat (cocoa butter, butter Karite, palm oil), is an essential ingredient for emulsifiers for both conventional cosmetics and natural cosmetics since it is an ecocert certified ingredient. Another component in the composition is the carbomer, a term used for a series of polymers made primarily from acrylic acid, often used as gels in cosmetics and personal care products. Carbomers help distribute or suspend an insoluble solid in a liquid. They are also used to maintain separation emulsions in their oil and liquid components. Carbomers are often used to control the consistency and flow of cosmetics and personal care products.

The composition also contains hydroxyethyl cellulose which is a gelling agent and thickener derived from cellulose. It is widely used in cosmetics, cleaning products and other household products.

Finally, Aloe Vera that has the property of destroying dead cells, allowing their elimination, and regulates the pH in the three layers of the skin (epidermis, dermis and hypodermis) so it has antiseptic and healing functions, deeply moisturizes and It is very useful in sensitive and damaged skin. It helps to smooth wrinkles, reduce the size of pores and is excellent as a sunscreen, by protecting from its harmful effects.

-Help prevent sunburn and is also very effective in relieving skin that has been exposed to the sun for a long time.

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The sunscreen venoprotective composition is a non-occlusive aqueous external gel-cream emulsion. The procedure of elaboration of the sunscreen venoprotective cream comprises the following operative stages:

a) The components of the aqueous phase that are constituted by the extracts selected from Pinus pinaster, Ruscus aculeatus, Centella asiatica and Castano de indias or a combination of these, glycerin, pentyl glycol, copolymer of eicosano and carbomer are mixed.

b) The water-soluble solids are dissolved as oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, and the mixture is left at least 24 hours at rest or until the carbomer is completely dissolved in water.

c) The components of the oil phase consisting of ethylhexyl are mixed

methoxycinnamate, Octocrylene, butylmethoxydibenzoylmethane,

hydroxyacetophenone and hydroxyethyl cellulose in another vessel by heating the mixture at a temperature between 40 and 75 degrees Celsius.

d) The mixture is stirred with gentle movements until the fatty solids are completely dissolved.

e) The mixture of the aqueous phase is heated to a temperature between 40 and 75 degrees Celsius.

f) The oil phase is added to the aqueous one and is stirred vigorously until the formation of an emulsion.

g) continue with softer agitation until cooling to room temperature

h) The pH is regulated between 6.5 and 7.5 with 10% sodium hydroxide

In the aqueous phase according to the invention it is constituted by water and other hydrophilic ingredients. It is also formed by moisturizing ingredients (such as vegetable glycerin or propylene glycol); water-soluble polymers (which increase viscosity or provide conditioning); and preservatives, dyes, or active ingredients (such as fruit and plant flower extracts or hydrolyzed proteins) In this case, the extracts selected from the group mentioned above are composed as:

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Pinus pinaster, Ruscus aculeatus, Centella asiatica and Castano de indias or a combination of these. Also the aqueous phase is composed of glycerin, pentyl glycol, copolymer of eicosano and carbomer.

The preparations according to the invention may also contain inorganic pigments, which are usually used in cosmetics for the protection of the skin against UV rays. It is in this respect the oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof,

As ^ as modifications in which oxides are the active agents. Particularly preferred are titanium dioxide based pigments.

The oil phase is formed by ingredients generally not compatible with water. In this class of ingredients are the materials

raw fats, oils and waxes, and all its derivatives, including alcohol and fatty acids, esters, hydrocarbons, glycerides and silicones. In this group is ethylhexyl methoxycinnamate, Octocrylene, butylmethoxydibenzoylmethane, hydroxyacetophenone and Hydroxyethyl cellulose.

The cosmetic preparations according to the invention may contain the cosmetic excipients currently used in said preparations, e.g. ex. preservatives, bactericides, perfumes, antifoaming agents, colorant, pigments with coloring power, thickeners, surfactants,

emulsifiers, plasticizers, wetting and / or moisture-retaining substances, fats, oils, waxes or other conventional components of a cosmetic formulation, such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicon derivatives.

Examples of venoprotective sunscreen compositions of the present invention are shown.

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Example 1

For the preparation of a sunscreen composition with 50 degree sunscreen, the following components described above have been combined in an approximate amount in% by weight of the mixture:

Ethylhexyl methoxycinnamate 10

Octocrylene 7

Butylmethoxidibenxoylmethane 5

Titanium dioxide 3

VP / Copolymer of Eicosano 2

Glycerin 3

Glycerin stearate peg 100 1

Pinus Pinaster 1 Extract

Aloe Vera Extract 1

Pentylene Glycol 1.5

0.5 hydroxyacetophenone

Carbomer 0.12

Perfume 0.4

0.15 hydroxyethyl cellulose

Sodium Hydroxide pH 6.5 Cs

Water 64.35

Example 2

For the preparation of a veoprotective composition with sunscreen grade 30, the following components have been combined in the amounts described below in% by weight of the mixture:

Ethylhexyl methoxycinnamate 7

Octocrylene 4

Butylmethoxidibenxoylmethane 4

Titanium dioxide 3

VP / CopoKmero of Eicosano 2

Glycerin stearate peg 100 1

Pinus Pinaster 1 Extract

Aloe Vera Extract 1

5 Pentylene Glycol 1.5

0.5 hydroxyacetophenone

0.1 Carbomer

Perfume 0.4

0.15 hydroxyethyl cellulose

10 Sodium Hydroxide pH 6.5 Cs

Water 74.33

Claims (1)

5 10 fifteen twenty 25 30 R E I V I N D I C A C I O N E S l.-Procedure for the preparation of a sunscreen venoprotective cream that is characterized by comprising the following operational stages: a) The components of the aqueous phase that are constituted by the extracts selected from Pinus pinaster, Ruscus aculeatus, Centella asiatica and Castano de indias or a combination of these, glycerin, pentyl glycol, copolymer of eicosano and carbomer are mixed. b) The water-soluble solids selected from the oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof are dissolved, and the mixture is left at least 24 hours at rest or until the carbomer is completely dissolved in water. c) The components of the oil phase consisting of ethylhexyl methoxycinnamate, Octocrylene, butylmethoxydibenzoylmethane, hydroxyacetophenone and Hydroxyethyl cellulose are mixed in another vessel by heating the mixture at a temperature between 40 and 75 degrees Celsius. d) The mixture is stirred with gentle movements until the fatty solids are completely dissolved. e) The mixture of the aqueous phase is heated to a temperature between 40 and 75 degrees Celsius. f) The oil phase is added to the aqueous one and is stirred vigorously until the formation of an emulsion. g) continue with softer agitation until cooling to room temperature h) The pH is regulated between 6.5 and 7.5 with 10% sodium hydroxide 2- Composition venoprotective and sunscreen obtained according to the procedure of revindication 1, which is characterized by the following approximate weight composition for a sun protection factor 50:
Ethylhexyl methoxycinnamate 10
Octocrylene 7
Butylmethoxidibenxoylmethane 5
Titanium dioxide 3
VP / CopoKmero of Eicosano 2
Glycerin 3
Glycerin stearate peg 100 1
Pinus Pinaster 1 Extract
5 Aloe Vera Extract 1
Pentylene Glycol 1.5
0.5 hydroxyacetophenone
Carbomer 0.12
Perfume 0.4
10 Hydroxyethyl Cellulose 0.15
Sodium Hydroxide pH 6.5 Cs
Water 64.35 3- Venoprotective composition and with sunscreen obtained according to the procedure of claim 1, characterized in that for a sun protection factor 30 the following approximate composition by weight is had:
Ethylhexyl methoxycinnamate 7
Octocrylene 4
20 Butylmethoxydibenxoylmethane 4
Titanium dioxide 3
VP / Copolymer of Eicosano 2
Glycerin stearate peg 100 1
Pinus Pinaster 1 Extract
25 Aloe Vera Extract 1
Pentylene Glycol 1.5
0.5 hydroxyacetophenone
0.1 Carbomer
Perfume 0.4
30 Hydroxyethyl Cellulose 0.15
Sodium Hydroxide pH 6.5 Cs
Water 74.33