ES2584068T3 - Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma - Google Patents
Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma Download PDFInfo
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- ES2584068T3 ES2584068T3 ES11773666.0T ES11773666T ES2584068T3 ES 2584068 T3 ES2584068 T3 ES 2584068T3 ES 11773666 T ES11773666 T ES 11773666T ES 2584068 T3 ES2584068 T3 ES 2584068T3
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| US390791P | 2010-10-07 | ||
| PCT/DK2011/050369 WO2012041328A1 (en) | 2010-10-01 | 2011-09-30 | Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain |
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| CN102164611B (zh) | 2008-07-24 | 2015-01-07 | Ns基因公司 | 生长因子metrnl的治疗用途 |
| JP6149226B2 (ja) | 2010-10-01 | 2017-06-21 | ホーバ セラピューティクス アンパルトセルスカブ | アロディニア、痛覚過敏、自発痛及び幻肢痛の処置 |
| CN107596346A (zh) | 2011-09-05 | 2018-01-19 | 霍巴治疗公司 | 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 |
| CN103685771A (zh) * | 2013-12-13 | 2014-03-26 | 苏州士丹尼信息技术有限公司 | 一种集成的信息交流系统 |
| CN107184956B (zh) * | 2016-03-14 | 2020-09-08 | 上海风劲生物医药科技有限公司 | Metrnl蛋白或基因在防治脓毒血症方面的应用 |
| WO2020163469A2 (en) | 2019-02-08 | 2020-08-13 | BioLegend, Inc. | METHODS FOR DETECTING METEORIN-β ACTIVITY |
| KR20240006581A (ko) | 2021-05-06 | 2024-01-15 | 호바 세라퓨틱스 에이피에스 | 화학요법-유도된 신경병성 통증의 예방 및 치료 |
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Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| CA1237671A (en) | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| WO1987000201A1 (en) | 1985-07-05 | 1987-01-15 | Whitehead Institute For Biomedical Research | Epithelial cells expressing foreign genetic material |
| US4883666A (en) | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5156844A (en) | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5185154A (en) | 1989-02-02 | 1993-02-09 | Liposome Technology, Inc. | Method for instant preparation of a drug containing large unilamellar vesicles |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| US5219990A (en) | 1991-01-28 | 1993-06-15 | Biogen, Inc. | Papillomavirus e2 trans-activation repressors |
| CA2109085C (en) | 1991-04-25 | 2003-03-11 | Keith E. Dionne | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| ATE226250T1 (de) | 1992-04-30 | 2002-11-15 | Innogenetics Nv | Polypeptide und peptide dafür kodierende nukleinsaüre und ihre verwendung im zusammenhang mit tumortherapie, entzündung oder immunology |
| WO1994012158A1 (en) | 1992-12-02 | 1994-06-09 | Alkermes Controlled Therapeutics, Inc. | Controlled release growth hormone containing microspheres |
| US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
| AU688776B2 (en) | 1993-06-23 | 1998-03-19 | Brown University Research Foundation | Method and apparatus for sealing implantable, membrane encapsulation devices |
| ATE218893T1 (de) | 1993-08-12 | 2002-06-15 | Neurotech Sa | Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten |
| EP0804249A2 (en) | 1994-03-15 | 1997-11-05 | Brown University Research Foundation | Polymeric gene delivery system |
| US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5656465A (en) | 1994-05-04 | 1997-08-12 | Therion Biologics Corporation | Methods of in vivo gene delivery |
| DK0779806T3 (da) | 1994-09-09 | 2000-11-27 | Takeda Chemical Industries Ltd | Præparat til forsinket frigivelse indeholdende et metalsalt af et peptid |
| US5677158A (en) | 1995-06-07 | 1997-10-14 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| NZ310644A (en) | 1995-06-07 | 1999-08-30 | Alkermes Inc | Composition for sustained release of human growth hormone |
| ZA965368B (en) | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
| US5904144A (en) | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
| US6027721A (en) | 1996-05-20 | 2000-02-22 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
| US6054142A (en) | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
| US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
| US6683058B1 (en) | 1998-04-15 | 2004-01-27 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
| DE69929600T2 (de) | 1998-05-27 | 2006-09-07 | Avigen Inc., Alameda | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren |
| US20020055467A1 (en) * | 1998-07-06 | 2002-05-09 | Johansen Teit E. | Novel neurotrophic factors |
| US6361771B1 (en) | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
| AU7452300A (en) | 1999-10-01 | 2001-05-10 | Kyowa Hakko Kogyo Co. Ltd. | Shear stress-response dna |
| WO2001039786A2 (en) | 1999-11-30 | 2001-06-07 | Innogenetics N.V. | New uses of suppressive macrophage activation factors |
| CA2395872A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| CA2395676A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| CA2399776A1 (en) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| CA2403901A1 (en) | 2000-05-02 | 2001-11-08 | Human Genome Sciences, Inc. | 29 human secreted proteins |
| US20020037281A1 (en) | 2000-05-26 | 2002-03-28 | Davidson Beverly L. | Methods of transducing neural cells using lentivirus vectors |
| US6555674B2 (en) | 2000-08-09 | 2003-04-29 | Nsgene A/S | JeT promoter |
| EP1395279B1 (en) | 2001-03-28 | 2011-10-05 | Biogen Idec MA Inc. | Use of neublastin polypeptides for treating neuropathic pain |
| AU2002364968A1 (en) | 2001-12-21 | 2003-09-02 | Diadexus, Inc. | Compositions and methods relating to hepatic specific genes and proteins |
| WO2004035732A2 (en) | 2002-08-29 | 2004-04-29 | Five Prime Therapeutics, Inc. | Human polypeptides encoded by polynucleotides and methods of their use |
| US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
| US20050208500A1 (en) | 2003-03-04 | 2005-09-22 | Erlander Mark G | Signatures of ER status in breast cancer |
| PL1745069T3 (pl) * | 2004-03-30 | 2009-10-30 | Nsgene As | Zastosowanie terapeutyczne czynnika wzrostu NSG33 |
| ES2375481T3 (es) | 2004-03-30 | 2012-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anticuerpos biespecíficos para elegir como diana células que participan en reacciones de tipo alérgico, composiciones y usos de los mismos. |
| US20070161696A1 (en) * | 2004-04-23 | 2007-07-12 | Zeldis Jerome B | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
| WO2006110593A2 (en) * | 2005-04-07 | 2006-10-19 | Macrogenics, Inc. | Biological targets for the diagnosis, treatment and prevention of cancer |
| EP1883446B8 (en) | 2005-05-17 | 2017-11-15 | Gloria Therapeutics Sarl | An implantable therapy system for treating a living being with an active factor |
| JP2009513584A (ja) | 2005-10-28 | 2009-04-02 | エヌエスゲーネ・アクティーゼルスカブ | Ｇｄｎｆの送達のための移植可能な生体適合性免疫隔離ビヒクル |
| JP2009527576A (ja) | 2006-02-24 | 2009-07-30 | ネオフアーム・インコーポレイテツド | カルジオリピン調製の方法および工程 |
| TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| WO2008136541A1 (en) * | 2007-05-02 | 2008-11-13 | Snu R&Db Foundation | Angiogenesis inhibitor comprising meteorin as an active ingredient |
| KR100823156B1 (ko) * | 2007-05-02 | 2008-04-22 | 재단법인서울대학교산학협력재단 | 메테오린을 유효성분으로 포함하는 혈관신생 억제제 |
| WO2009069764A1 (ja) * | 2007-11-30 | 2009-06-04 | National University Corporation Chiba University | オピオイド鎮痛剤 |
| CN102164611B (zh) * | 2008-07-24 | 2015-01-07 | Ns基因公司 | 生长因子metrnl的治疗用途 |
| WO2010021882A2 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
| CA2739416C (en) * | 2008-09-03 | 2017-10-31 | Arbor Vita Corporation | Agents and methods for treatment of pain |
| TW201031650A (en) * | 2008-12-02 | 2010-09-01 | Organon Nv | 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione |
| JP6149226B2 (ja) | 2010-10-01 | 2017-06-21 | ホーバ セラピューティクス アンパルトセルスカブ | アロディニア、痛覚過敏、自発痛及び幻肢痛の処置 |
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2011
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- 2011-09-30 CN CN201810021543.XA patent/CN108079279B/zh active Active
- 2011-09-30 CN CN2011800580444A patent/CN103269708A/zh active Pending
- 2011-09-30 WO PCT/DK2011/050369 patent/WO2012041328A1/en not_active Ceased
- 2011-09-30 ES ES11773666.0T patent/ES2584068T3/es active Active
- 2011-09-30 CA CA2813013A patent/CA2813013C/en active Active
- 2011-09-30 AU AU2011307488A patent/AU2011307488B2/en active Active
- 2011-09-30 EP EP11773666.0A patent/EP2621512B1/en active Active
- 2011-09-30 KR KR1020137011264A patent/KR101886029B1/ko active Active
- 2011-10-03 US US13/251,630 patent/US8404642B2/en active Active
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2011307488A1 (en) | 2013-05-02 |
| JP6149226B2 (ja) | 2017-06-21 |
| US8404642B2 (en) | 2013-03-26 |
| EP2621512B1 (en) | 2016-04-06 |
| US8815810B2 (en) | 2014-08-26 |
| CA2813013C (en) | 2019-10-22 |
| WO2012041328A1 (en) | 2012-04-05 |
| CA2813013A1 (en) | 2012-04-05 |
| HK1186412A1 (zh) | 2014-03-14 |
| KR20130108380A (ko) | 2013-10-02 |
| US20150202262A1 (en) | 2015-07-23 |
| CN103269708A (zh) | 2013-08-28 |
| EP2621512A1 (en) | 2013-08-07 |
| AU2011307488B2 (en) | 2015-08-20 |
| US20120108518A1 (en) | 2012-05-03 |
| JP6247734B2 (ja) | 2017-12-13 |
| JP2013543378A (ja) | 2013-12-05 |
| JP2017052783A (ja) | 2017-03-16 |
| US20130303459A1 (en) | 2013-11-14 |
| CN108079279B (zh) | 2022-04-12 |
| KR101886029B1 (ko) | 2018-08-07 |
| CN108079279A (zh) | 2018-05-29 |
| US9314502B2 (en) | 2016-04-19 |
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