ES2570310T3 - Composiciones para la vacunación por vía cutánea - Google Patents
Composiciones para la vacunación por vía cutáneaInfo
- Publication number
- ES2570310T3 ES2570310T3 ES08864603T ES08864603T ES2570310T3 ES 2570310 T3 ES2570310 T3 ES 2570310T3 ES 08864603 T ES08864603 T ES 08864603T ES 08864603 T ES08864603 T ES 08864603T ES 2570310 T3 ES2570310 T3 ES 2570310T3
- Authority
- ES
- Spain
- Prior art keywords
- skin
- vaccine formulation
- mammal
- dry
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000002255 vaccination Methods 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Surgical Instruments (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Utilización de una formulación de vacuna para la preparación de una composición para la vacunación epicutánea de un mamífero, preferentemente un humano, caracterizada por que la formulación de vacuna está en forma seca y desprovista de adyuvante, y por que se administra por aplicación sobre la piel intacta del mamífero por medio de un dispositivo cutáneo que forma en contacto con la piel un compartimento de condensación que posee un volumen comprendido entre 1 y 300 mm3/cm2 de superficie del dispositivo, conteniendo dicho dispositivo una cantidad de formulación de vacuna comprendida entre 0,1 μg y 500 μg por cm2 de superficie, manteniéndose el dispositivo sobre la piel durante un periodo de 6 a 72 horas, e induciendo dicha aplicación de la formulación en forma seca y desprovista de adyuvante sobre la piel intacta una respuesta inmune específica de antígeno caracterizada por la producción de anticuerpos del tipo IgG.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0759505A FR2924350B1 (fr) | 2007-12-03 | 2007-12-03 | Procede et compositions pour la vaccination par voie cutanee |
PCT/FR2008/052198 WO2009080933A1 (fr) | 2007-12-03 | 2008-12-03 | Procede et compositions pour la vaccination par voie cutanee |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570310T3 true ES2570310T3 (es) | 2016-05-17 |
Family
ID=39537456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08864603T Active ES2570310T3 (es) | 2007-12-03 | 2008-12-03 | Composiciones para la vacunación por vía cutánea |
Country Status (10)
Country | Link |
---|---|
US (1) | US8968743B2 (es) |
EP (1) | EP2217222B1 (es) |
JP (1) | JP6017111B2 (es) |
KR (1) | KR101605694B1 (es) |
CN (2) | CN104721815A (es) |
CA (1) | CA2706363C (es) |
ES (1) | ES2570310T3 (es) |
FR (1) | FR2924350B1 (es) |
IL (1) | IL205821A (es) |
WO (1) | WO2009080933A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
FR2926466B1 (fr) * | 2008-01-23 | 2010-11-12 | Dbv Tech | Procede de fabrication de patchs par electrospray |
CN107320722A (zh) | 2009-09-07 | 2017-11-07 | Dbv技术公司 | 治疗嗜酸细胞性食管炎的方法 |
AU2011239941B2 (en) * | 2010-04-16 | 2015-07-16 | Dbv Technologies | Method of vaccination |
DK3562451T3 (da) * | 2016-12-30 | 2022-02-07 | Euromed Inc | Klæbeplaster med forbedret skillelagsystem |
US11938178B2 (en) | 2018-07-09 | 2024-03-26 | Dbv Technologies | Optimized epicutaneous vaccination |
CN112869865B (zh) * | 2021-01-11 | 2022-09-02 | 贵阳德漫多医疗科技有限公司 | 一种皮肤热剥脱装置 |
EP4201383A1 (en) | 2021-12-21 | 2023-06-28 | DBV Technologies | Improved patches and methods for delivering an active substance to the skin using the same |
WO2023066846A1 (en) | 2021-10-18 | 2023-04-27 | Dbv Technologies | Improved patches and methods for delivering an active substance to the skin using the same |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB501873A (en) | 1937-04-20 | 1939-03-07 | Hermann Vollmer | New or improved means for carrying out medical tests |
US3212495A (en) | 1962-06-22 | 1965-10-19 | Hazleton Lab Inc | Sensitivity test patches |
BE642548A (es) | 1963-01-19 | 1964-05-14 | ||
SE337223B (es) | 1967-05-23 | 1971-08-02 | Pharmacia Ab | |
US3837340A (en) | 1971-10-20 | 1974-09-24 | Lilly Co Eli | Device for administering immunication against virus |
US3894531A (en) | 1974-04-12 | 1975-07-15 | Jr Milton A Saunders | Skin patch test device with peelable label |
US4450844A (en) | 1981-11-23 | 1984-05-29 | Hill Top Research, Inc. | Patch system for use on the skin |
US4435180A (en) | 1982-05-25 | 1984-03-06 | Alza Corporation | Elastomeric active agent delivery system and method of use |
AU590711B2 (en) | 1982-10-13 | 1989-11-16 | Biowhittaker, Inc. | Stable allergenic extracts and methods |
SE8404895L (sv) | 1984-10-01 | 1986-03-17 | Torkel Ingemar Fischer | Medel for en overkenslighetstest |
US4743249A (en) | 1986-02-14 | 1988-05-10 | Ciba-Geigy Corp. | Dermal and transdermal patches having a discontinuous pattern adhesive layer |
US4781705A (en) | 1987-06-16 | 1988-11-01 | Zyton Inc. | Mineral applicator |
US4788971A (en) | 1987-07-13 | 1988-12-06 | Hill Top Research, Inc. | Patch system for use on the skin |
US4821733A (en) | 1987-08-18 | 1989-04-18 | Dermal Systems International | Transdermal detection system |
US5438984A (en) | 1988-09-08 | 1995-08-08 | Sudor Partners | Apparatus and method for the collection of analytes on a dermal patch |
US5037587A (en) | 1989-07-17 | 1991-08-06 | Mitsui Toatsu Chemicals, Inc. | Preparation process of polyimide film |
US5236455A (en) | 1992-02-10 | 1993-08-17 | Wilk Peter J | Tympanic patch, applicator, and related method |
JPH06238008A (ja) | 1993-02-15 | 1994-08-30 | Yuutoku Yakuhin Kogyo Kk | パッチテスト用具 |
AU5543196A (en) | 1995-04-12 | 1996-10-30 | Robert B. Hopp | Skin patch for use in contact immunotherapy |
US6093419A (en) | 1995-06-07 | 2000-07-25 | Lectec Corporation | Compliance verification method and device in compulsory drug administration |
US5827530A (en) | 1996-02-05 | 1998-10-27 | Reed, Jr.; Fred Dewitt | Fillable patch for dermal or transdermal delivery |
US5827608A (en) | 1996-10-28 | 1998-10-27 | Minnesota Mining And Manufacturing Company | Method of forming a thermoplastic layer on a flexible two-dimensional substrate and powder for preparing same |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
DE29621365U1 (de) | 1996-12-11 | 1997-02-27 | Lohmann Gmbh & Co Kg | Epikutan-Testpflaster |
US5827068A (en) * | 1996-12-31 | 1998-10-27 | Michelson Packaging Co. | Fruit packaging tray usable with a denesting apparatus |
US20020102291A1 (en) | 1997-12-15 | 2002-08-01 | Noven Pharmaceuticals, Inc. | Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
US6210705B1 (en) | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
EP1356821B1 (en) | 1998-02-25 | 2007-06-20 | THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY | Use of skin penetration enhancers and barrier disruption agents to enhance transcutaneous immune response |
FR2781670B1 (fr) | 1998-07-30 | 2001-09-07 | Oreal | Patch cosmetique ou pharmaceutique et son conditionnement |
JP2987702B1 (ja) | 1998-09-07 | 1999-12-06 | 岩手新浄農業協同組合 | 粉末青果物の製造方法 |
US6159497A (en) | 1998-10-30 | 2000-12-12 | Noven Pharmaceuticals, Inc. | Patch applicator |
WO2000043058A1 (en) | 1999-01-22 | 2000-07-27 | Powderject Research Limited | Method of enhancing needleless transdermal powdered drug delivery |
SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
AU4188100A (en) * | 1999-04-08 | 2000-11-14 | Gregory M. Glenn | Dry formulation for transcutaneous immunization |
US6316598B1 (en) | 1999-09-13 | 2001-11-13 | Keraplast Technologies, Ltd. | Water absorbent keratin and gel formed therefrom |
AU784593B2 (en) | 2000-01-06 | 2006-05-11 | Marantech Holding, Llc | Compositions and methods for facilitating skin growth and managing skin conditions |
WO2001053331A2 (en) | 2000-01-24 | 2001-07-26 | Adherex Technologies, Inc. | Peptidomimetic modulators of cell adhesion |
US20020151487A1 (en) | 2000-08-31 | 2002-10-17 | Loyola University Chicago | Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway |
RU2277390C2 (ru) | 2000-10-13 | 2006-06-10 | Алза Корпорейшн | Аппликатор для силового воздействия комплектом микроножей |
WO2002076379A2 (en) | 2000-11-16 | 2002-10-03 | Chris Lipper | Medicated tattoos |
PT1372708E (pt) * | 2001-02-13 | 2008-09-29 | Us Gov Sec Army | Vacina para imunização transcutânea |
FR2822049B1 (fr) * | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
US7635488B2 (en) * | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
JP2004525921A (ja) | 2001-03-19 | 2004-08-26 | イオマイ コーポレイシヨン | 経皮免疫用パッチ |
US20050074462A1 (en) | 2001-05-23 | 2005-04-07 | Duotol Ab | Supression of allergic reactions by transdermal administration of allergens conjugated to cholera toxin or fragments thereof |
US7195774B2 (en) | 2001-08-29 | 2007-03-27 | Carvalho Ricardo Azevedo Ponte | Implantable and sealable system for unidirectional delivery of therapeutic agents to tissues |
US20040137004A1 (en) | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
DE60330257D1 (de) * | 2002-10-02 | 2010-01-07 | Nordic Vaccine Technology As | Zusammensetzung zur impfung |
US20060147509A1 (en) | 2002-10-02 | 2006-07-06 | Kirkby Nikolai S | Composition for vaccination |
US20040111071A1 (en) | 2002-12-09 | 2004-06-10 | Jeffrey Lewis Powers | Portable device for dispensing hand treatments |
FR2866553B1 (fr) | 2004-02-19 | 2006-06-09 | Dbv Tech | Nouveau type de patch |
WO2006007366A2 (en) | 2004-06-15 | 2006-01-19 | Iomai Corporation | SKIN IMMUNIZATION USING LT-STa FUSION PROTEINS |
JP5186678B2 (ja) * | 2005-10-13 | 2013-04-17 | 財団法人ヒューマンサイエンス振興財団 | 経皮抗原投与のための抗原キット |
-
2007
- 2007-12-03 FR FR0759505A patent/FR2924350B1/fr active Active
-
2008
- 2008-12-03 WO PCT/FR2008/052198 patent/WO2009080933A1/fr active Application Filing
- 2008-12-03 KR KR1020107011702A patent/KR101605694B1/ko active IP Right Grant
- 2008-12-03 CN CN201510087956.4A patent/CN104721815A/zh active Pending
- 2008-12-03 US US12/745,673 patent/US8968743B2/en active Active
- 2008-12-03 ES ES08864603T patent/ES2570310T3/es active Active
- 2008-12-03 EP EP08864603.9A patent/EP2217222B1/fr active Active
- 2008-12-03 JP JP2010536516A patent/JP6017111B2/ja active Active
- 2008-12-03 CA CA2706363A patent/CA2706363C/fr active Active
- 2008-12-03 CN CN2008801188650A patent/CN101883560A/zh active Pending
-
2010
- 2010-05-17 IL IL205821A patent/IL205821A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
KR101605694B1 (ko) | 2016-03-24 |
CN101883560A (zh) | 2010-11-10 |
IL205821A (en) | 2017-03-30 |
JP2011505412A (ja) | 2011-02-24 |
FR2924350A1 (fr) | 2009-06-05 |
KR20100093536A (ko) | 2010-08-25 |
JP6017111B2 (ja) | 2016-10-26 |
EP2217222A1 (fr) | 2010-08-18 |
AU2008339832A1 (en) | 2009-07-02 |
EP2217222B1 (fr) | 2016-02-17 |
FR2924350B1 (fr) | 2010-08-13 |
US20100310596A1 (en) | 2010-12-09 |
CA2706363C (fr) | 2016-09-13 |
CN104721815A (zh) | 2015-06-24 |
US8968743B2 (en) | 2015-03-03 |
CA2706363A1 (fr) | 2009-07-02 |
WO2009080933A1 (fr) | 2009-07-02 |
IL205821A0 (en) | 2010-11-30 |
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