ES2570158T3 - Tratamiento de la isquemia de extremidades - Google Patents

Tratamiento de la isquemia de extremidades

Info

Publication number
ES2570158T3
ES2570158T3 ES10703115T ES10703115T ES2570158T3 ES 2570158 T3 ES2570158 T3 ES 2570158T3 ES 10703115 T ES10703115 T ES 10703115T ES 10703115 T ES10703115 T ES 10703115T ES 2570158 T3 ES2570158 T3 ES 2570158T3
Authority
ES
Spain
Prior art keywords
limb ischemia
treatment
disease
critical limb
buerger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10703115T
Other languages
English (en)
Inventor
John Sinden
Erik Miljan
Paolo Madeddu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reneuron Ltd
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Application granted granted Critical
Publication of ES2570158T3 publication Critical patent/ES2570158T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)

Abstract

El uso de células madre neuronales en la fabricación de un medicamento para el tratamiento de un paciente que padece arteriopatía periférica, en el que la enfermedad es isquemia de extremidades aguda o crítica, enfermedad de Buerger o isquemia de extremidades crítica en la diabetes.
ES10703115T 2009-02-06 2010-02-05 Tratamiento de la isquemia de extremidades Active ES2570158T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0902034.8A GB0902034D0 (en) 2009-02-06 2009-02-06 Method
PCT/GB2010/050185 WO2010089605A1 (en) 2009-02-06 2010-02-05 Treatment of limb ischemia

Publications (1)

Publication Number Publication Date
ES2570158T3 true ES2570158T3 (es) 2016-05-17

Family

ID=40469746

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10703115T Active ES2570158T3 (es) 2009-02-06 2010-02-05 Tratamiento de la isquemia de extremidades

Country Status (8)

Country Link
US (2) US8932577B2 (es)
EP (1) EP2393920B1 (es)
JP (2) JP5845089B2 (es)
AU (1) AU2010212147B2 (es)
CA (1) CA2747308C (es)
ES (1) ES2570158T3 (es)
GB (1) GB0902034D0 (es)
WO (1) WO2010089605A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
RU2562111C2 (ru) 2010-08-19 2015-09-10 Ф.Хоффманн-Ля Рош Аг Конверсия соматических клеток в индуцированные репрограмированные нейрональные стволовые клетки (ирнск)
WO2013160861A1 (en) * 2012-04-27 2013-10-31 Aïmago S.A. Optical coherent imaging medical device

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4125373A1 (de) 1991-07-31 1993-02-04 Siemens Ag Sensorschlauch zur ueberwachung eines mediums
GB9518606D0 (en) 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
WO1999037751A1 (en) * 1998-01-23 1999-07-29 Imclone Systems Incorporated Purified populations of stem cells
JP4740452B2 (ja) 1998-03-18 2011-08-03 オシリス セラピューティクス，インコーポレイテッド 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法、組成物およびその使用法
US6045990A (en) 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
WO2000018414A1 (en) 1998-09-29 2000-04-06 Diacrin, Inc. Transplantation of neural cells for the treatment of ischemic damage due to stroke
GB9904281D0 (en) 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
US20070048726A1 (en) 2000-01-14 2007-03-01 Biolife Solutions, Inc. Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State
US7514259B2 (en) 2000-02-11 2009-04-07 Schepens Eye Research Institute Isolation and transplantation of retinal stem cells
JP2002171965A (ja) * 2000-12-04 2002-06-18 Kansai Tlo Kk 骨髄単核球細胞の分離、濃縮方法及び血管再生剤
GB0125773D0 (en) 2001-10-26 2001-12-19 Reneuron Ltd Constructs
US7635467B2 (en) 2002-01-14 2009-12-22 The Board Of Trustees Of The University Of Illinois Mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof
RU2346981C2 (ru) 2002-07-19 2009-02-20 Веста Терапьютикс, Инк. Способ получения жизнеспособных клеток печени человека, в том числе печеночных стволовых клеток/клеток-предшественников
US7470538B2 (en) 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
WO2005014792A2 (en) 2003-08-08 2005-02-17 The General Hospital Corporation D/B/A Massachusetts General Hospital Preservation of biomaterials with transported preservation agents
AU2004272340B2 (en) 2003-09-12 2008-01-03 Dana Farber Cancer Institute Immortalisation of mammalian cells and therapeutic applications of said cells
JP4481706B2 (ja) 2004-03-31 2010-06-16 独立行政法人科学技術振興機構 脳梗塞疾患モデルマウス
GB0420963D0 (en) 2004-09-21 2004-10-20 Reneuron Ltd Hepatocyte
ATE373081T1 (de) 2004-09-30 2007-09-15 Reneuron Ltd Zelllinie
IN2014CN03629A (es) * 2004-11-17 2015-09-04 Neuralstem Inc
JP4734669B2 (ja) 2005-02-04 2011-07-27 独立行政法人産業技術総合研究所 ヒト歯乳頭からの幹細胞及びその利用方法
JP2008542252A (ja) 2005-05-26 2008-11-27 インターサイテックス リミティド 同種真皮繊維芽細胞を用いる組織修復
EP2662439A1 (en) 2005-05-27 2013-11-13 Viacord, LLC Treatment of ischemia using stem cells
WO2007013771A1 (en) * 2005-07-28 2007-02-01 Brainguard Co., Ltd. Carbon nanotubes serving as stem cell scaffold
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GB0703188D0 (en) 2007-02-19 2007-03-28 Roger Land Building Large scale production of stem cells
WO2008152640A2 (en) 2007-06-13 2008-12-18 Pluristem Ltd. Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells
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WO2009120996A1 (en) 2008-03-27 2009-10-01 Biolife Solutions, Inc. Mehtod, system, and apparatus for hypothermic collection, storage, transport and banking of birth tissue
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
GB201011589D0 (en) 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells

Also Published As

Publication number Publication date
AU2010212147B2 (en) 2014-03-20
WO2010089605A1 (en) 2010-08-12
JP2012516884A (ja) 2012-07-26
US8932577B2 (en) 2015-01-13
GB0902034D0 (en) 2009-03-11
CA2747308A1 (en) 2010-08-12
CA2747308C (en) 2017-01-03
EP2393920B1 (en) 2016-02-03
US20120093786A1 (en) 2012-04-19
JP5845089B2 (ja) 2016-01-20
US9410122B2 (en) 2016-08-09
US20140341868A1 (en) 2014-11-20
JP2014167017A (ja) 2014-09-11
AU2010212147A1 (en) 2011-07-07
EP2393920A1 (en) 2011-12-14

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ES2570158T3 (es) Tratamiento de la isquemia de extremidades