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Boehringer Ingelheim Pharma GmbH and Co KG
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Dr Karl Thomae GmbH
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Publication of ES256603A1publicationCriticalpatent/ES256603A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Procedure for obtaining basically substituted carbinoles of the general formula **(See formula)** where R1 represents a low molecular weight alkyl residue, R2 hydrogen, a low molecular weight alkyl residue, an optionally substituted aryl or aralkyl residue, R3 and R4, which may be the same or different, represent hydrogen, an alkyl or alkoxy residue of low molecular weight, halogen or a tertiary amino group, R5 and R6, which may be the same or different, represent hydrogen or a low molecular weight residue, and R5 and R6, together with the nitrogen atom, may also form a pyrrolidine ring, piperidine or morpholine, and where n represents the number 1 or 2, as well as their racemates and their optically active components and/or their acid addition salts, characterized by transforming ketones of the general formula **(See formula)** where R1, R2, R5 and R6 have the above meaning, with Grignard compounds of the formula **(See formula)** where R3, R4 and n have the above meaning and X represents a halogen atom, or ketones of the general formula to be transformed **(See formula)** where R2 to R6 and n have the above meaning, with Grignard compounds of the formula R1MgX where R1 and X have the previous meaning, or by being transformed simultaneously or in succession with any 2 Grignard compounds of the formula **(See formula)** where R1, R3, R4 and X have the above meaning, basically substituted propionic acid esters of the formula **(See formula)** in which R2, R5, and R6 have the aforementioned meaning and R7 represents a low molecular weight alkyl moiety, eventually the compounds obtained being transformed into their racemates and respectively into their optically active components and/or their acid addition salts. (Machine-translation by Google Translate, not legally binding)
ES0256603A1959-05-211960-03-17Procedure for obtaining carbinols replaced basically (Machine-translation by Google Translate, not legally binding)
ExpiredES256603A1
(en)
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