ES273400A1 - Procedure for the obtaining of new derivatives of the quinolein (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new derivatives of the quinolein (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES273400A1 ES273400A1 ES273400A ES273400A ES273400A1 ES 273400 A1 ES273400 A1 ES 273400A1 ES 273400 A ES273400 A ES 273400A ES 273400 A ES273400 A ES 273400A ES 273400 A1 ES273400 A1 ES 273400A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see formula
- reacted
- compound
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229960005141 piperazine Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining new derivatives of quinoline, of the general formula: ** (See formula) ** wherein A represents a straight or branched divalent aliphatic hydrocarbon chain with 2 to 6 carbon atoms and whose piperazine nucleus can be replaced by one or more alkyl groups having 1 to 4 carbon atoms, as well as their addition salts, being characterized by the fact that a bis (aminoalcohyl) -1,4 piperazine of the general formula is reacted: ** (See formula) ** where A has the same meaning as above, with a compound of the formula: ** (See formula) ** wherein Y represents an atom or group reactive on an amino group; or the piperazine is reacted with a compound of the general formula: ** (See formula) ** wherein A has the same meaning as above, X represents a reactive ester residue and R represents a hydrogen atom or a protecting group of the amino group, capable of being then easily removed, or a compound of the formula is reacted: ** (See formula) ** with a quinolein of the formula: ** (See formula) ** wherein A and X have the same meanings as above and R represents a hydrogen atom or a protective radical of the amino group, capable of being then easily removed, and optionally optically inactive stereoisomeric forms are separated when the A chain has an atom of asymmetric carbon and eventually the bases are transformed into salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR848669 | 1961-01-03 | ||
| FR863189 | 1961-05-29 | ||
| FR879154 | 1961-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES273400A1 true ES273400A1 (en) | 1962-10-01 |
Family
ID=27245808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES273400A Expired ES273400A1 (en) | 1961-01-03 | 1962-01-03 | Procedure for the obtaining of new derivatives of the quinolein (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| AT (3) | AT241469B (en) |
| CH (1) | CH414636A (en) |
| ES (1) | ES273400A1 (en) |
| GB (1) | GB973903A (en) |
| LU (1) | LU40911A1 (en) |
| SE (1) | SE304005B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9555364B2 (en) * | 2009-06-30 | 2017-01-31 | Nalco Company | Acid gas scrubbing composition |
| US8461335B2 (en) * | 2009-06-30 | 2013-06-11 | Nalco Company | Acid gas scrubbing composition |
| US8765083B2 (en) * | 2010-11-19 | 2014-07-01 | Nalco Company | Acid gas absorbent composition |
-
1961
- 1961-12-06 LU LU40911D patent/LU40911A1/xx unknown
- 1961-12-27 CH CH1501461A patent/CH414636A/en unknown
-
1962
- 1962-01-02 GB GB148/62A patent/GB973903A/en not_active Expired
- 1962-01-02 SE SE18/62A patent/SE304005B/xx unknown
- 1962-01-03 AT AT410563A patent/AT241469B/en active
- 1962-01-03 AT AT410463A patent/AT241468B/en active
- 1962-01-03 AT AT3362A patent/AT241467B/en active
- 1962-01-03 ES ES273400A patent/ES273400A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT241468B (en) | 1965-07-26 |
| GB973903A (en) | 1964-11-04 |
| CH414636A (en) | 1966-06-15 |
| AT241469B (en) | 1965-07-26 |
| LU40911A1 (en) | 1962-02-06 |
| AT241467B (en) | 1965-07-26 |
| SE304005B (en) | 1968-09-16 |
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