ES2564290T3 - Inmunoensayo de flujo lateral para la activación de complemento y métodos de uso para evaluación del sitio de atención de trastornos asociados a complemento - Google Patents
Inmunoensayo de flujo lateral para la activación de complemento y métodos de uso para evaluación del sitio de atención de trastornos asociados a complemento Download PDFInfo
- Publication number
- ES2564290T3 ES2564290T3 ES11842681.6T ES11842681T ES2564290T3 ES 2564290 T3 ES2564290 T3 ES 2564290T3 ES 11842681 T ES11842681 T ES 11842681T ES 2564290 T3 ES2564290 T3 ES 2564290T3
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- Prior art keywords
- complement
- ic3b
- lateral flow
- complement activation
- intact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40929710P | 2010-11-02 | 2010-11-02 | |
| US409297P | 2010-11-02 | ||
| PCT/US2011/058945 WO2012071145A1 (en) | 2010-11-02 | 2011-11-02 | Lateral flow immunoassay for complement activation and methods of use for point-of-care assessment of complement-associated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2564290T3 true ES2564290T3 (es) | 2016-03-21 |
Family
ID=46146161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11842681.6T Active ES2564290T3 (es) | 2010-11-02 | 2011-11-02 | Inmunoensayo de flujo lateral para la activación de complemento y métodos de uso para evaluación del sitio de atención de trastornos asociados a complemento |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9182396B2 (enExample) |
| EP (2) | EP3095876A1 (enExample) |
| JP (1) | JP5859557B2 (enExample) |
| AU (2) | AU2011332241B2 (enExample) |
| CA (1) | CA2816423A1 (enExample) |
| ES (1) | ES2564290T3 (enExample) |
| MX (1) | MX340094B (enExample) |
| WO (1) | WO2012071145A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8865164B2 (en) * | 2010-11-02 | 2014-10-21 | Kypha, Inc. | Detecting complement activation |
| EP3095876A1 (en) | 2010-11-02 | 2016-11-23 | Kypha, Inc. | Point of care lateral flow immunoassay for complement activation and methods of use for point-of-care assessment of complement-associated disorders |
| US9110030B2 (en) | 2012-06-29 | 2015-08-18 | Daniel A. Kerschensteiner | Colorimetric gelatinase assay |
| US9863944B2 (en) | 2013-06-10 | 2018-01-09 | Asahi Kasei Fibers Corporation | Immunochromatographic diagnosis kit |
| ES2842283T3 (es) * | 2014-05-02 | 2021-07-13 | Uab Research Foundation | Métodos y composiciones para el diagnóstico y tratamiento de la meningitis |
| US11029318B2 (en) * | 2015-08-28 | 2021-06-08 | Kypha, Inc. | Methods for predicting and treating patients with increased risk of adverse pregnancy outcome |
| KR102141591B1 (ko) * | 2016-05-13 | 2020-09-14 | 광주과학기술원 | 진단용 키트 |
| WO2019190877A1 (en) * | 2018-03-26 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | High throughput method for measuring the protease activity of complement c3 convertase |
| EP3581934A1 (en) * | 2018-06-14 | 2019-12-18 | Otto-von-Guericke-Universität Magdeburg | Complement factors for diagnosis of low-grade infections in a human subject |
| WO2021222169A1 (en) * | 2020-04-27 | 2021-11-04 | Zinselmeyer Bernd H | Methods and systems for lateral flow immunoassay of various biological materials including sars-cov2 |
| EP4217744A4 (en) * | 2020-09-28 | 2024-11-06 | Allegheny Singer Research Institute | METHOD FOR DETERMINING A LEVEL OF A CELL FRAGMENT-BOUND COMPLEMENT ACTIVATION PRODUCT |
| EP4286850A4 (en) * | 2021-01-26 | 2024-11-27 | Sekisui Medical Co., Ltd. | IMMUNOLOGICAL ASSAY PROCEDURE |
| EP4334719A4 (en) * | 2021-05-07 | 2025-04-16 | Kypha, Inc. | TARGET MEASUREMENT |
| WO2023192436A1 (en) * | 2022-03-31 | 2023-10-05 | Alexion Pharmaceuticals, Inc. | Singleplex or multiplexed assay for complement markers in fresh biological samples |
Family Cites Families (20)
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|---|---|---|---|---|
| US5212071A (en) * | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
| JPS595958B2 (ja) | 1975-12-30 | 1984-02-08 | トウキヨウケイソウ カブシキガイシヤ | 変量測定・伝送装置 |
| EP0097440B1 (en) * | 1982-06-14 | 1986-09-24 | The Upjohn Company | Method and kit for removing and assaying complement system fragments |
| SE452067B (sv) * | 1986-04-11 | 1987-11-09 | Ulf R Nilsson | Reagens for och sett vid immunkemisk bestemning av c3a |
| SE452065B (sv) | 1986-04-11 | 1987-11-09 | Ulf R Nilsson | Antikroppspreparation vars antikroppar er specifika for determinanter i c3 b regionen hos denaturerat humant c3 samt dess anvendning och framstellning |
| IL89790A (en) * | 1988-04-01 | 2002-05-23 | Johns Hopking University | Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification |
| US7371582B2 (en) * | 2002-01-23 | 2008-05-13 | Boditechmed Inc. | Lateral flow quantitative assay method and strip and laser-induced fluorescence detection device therefor |
| WO2004093636A2 (en) * | 2003-04-17 | 2004-11-04 | Rauno Joks | PLASMA C5a LEVELS AS AN INDICATOR OF ASTHMA SEVERITY |
| KR20060015646A (ko) | 2003-06-13 | 2006-02-17 | 유니버시티 오브 피츠버그 | 면역, 혈액 및 염증성 질환의 모니터링 방법 |
| ATE421093T1 (de) | 2003-09-29 | 2009-01-15 | Peas Inst Ab | Schnelle bestimmung verschiedener formen von hgf (heptocyte growth factor) in den körperflüssigkeiten |
| US20050255533A1 (en) * | 2004-02-10 | 2005-11-17 | Brendan Bioscience, Llc | Comprehensive food allergy test |
| US20060292700A1 (en) * | 2005-06-22 | 2006-12-28 | Naishu Wang | Diffused interrupted lateral flow immunoassay device and method |
| WO2006124888A2 (en) | 2005-05-16 | 2006-11-23 | Brendan Bioscience, Llc | Detection of antigen specific immunocomplexes |
| US7910381B2 (en) | 2005-10-13 | 2011-03-22 | BioAssay Works | Immuno gold lateral flow assay |
| US8192742B2 (en) * | 2007-03-23 | 2012-06-05 | NovelMed Therapeutics | Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof |
| JP2012503170A (ja) * | 2008-07-15 | 2012-02-02 | ラピッド パトゲン スクリーニング，インク． | 側方流動イムノアッセイにおけるインサイツでの細胞の溶解 |
| CA2750155A1 (en) * | 2008-12-30 | 2010-07-08 | Centocor Ortho Biotech Inc. | Serum markers predicting clinical response to anti-tnf.alpha. antibodiesin patients with ankylosing spondylitis |
| US9291622B2 (en) * | 2009-05-21 | 2016-03-22 | Apellis Pharmaceuticals, Inc. | Complement assays and uses thereof |
| US8865164B2 (en) | 2010-11-02 | 2014-10-21 | Kypha, Inc. | Detecting complement activation |
| EP3095876A1 (en) | 2010-11-02 | 2016-11-23 | Kypha, Inc. | Point of care lateral flow immunoassay for complement activation and methods of use for point-of-care assessment of complement-associated disorders |
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| AU2016200772A1 (en) | 2016-02-25 |
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| US20120141457A1 (en) | 2012-06-07 |
| EP2635702A4 (en) | 2014-04-02 |
| MX340094B (es) | 2016-06-27 |
| EP3095876A1 (en) | 2016-11-23 |
| JP2014502347A (ja) | 2014-01-30 |
| US9939446B2 (en) | 2018-04-10 |
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