ES2561536T3 - Derivados de estradiol sustituidos en posición 6 para uso en la remielinación de los axones nerviosos - Google Patents
Derivados de estradiol sustituidos en posición 6 para uso en la remielinación de los axones nerviosos Download PDFInfo
- Publication number
- ES2561536T3 ES2561536T3 ES12761491.5T ES12761491T ES2561536T3 ES 2561536 T3 ES2561536 T3 ES 2561536T3 ES 12761491 T ES12761491 T ES 12761491T ES 2561536 T3 ES2561536 T3 ES 2561536T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- cyclopenta
- phenanthrene
- decahydro
- nch3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161454873P | 2011-03-21 | 2011-03-21 | |
| US201161454873P | 2011-03-21 | ||
| PCT/US2012/029973 WO2012129324A2 (en) | 2011-03-21 | 2012-03-21 | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2561536T3 true ES2561536T3 (es) | 2016-02-26 |
Family
ID=46877849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12761491.5T Active ES2561536T3 (es) | 2011-03-21 | 2012-03-21 | Derivados de estradiol sustituidos en posición 6 para uso en la remielinación de los axones nerviosos |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9364486B2 (https=) |
| EP (1) | EP2688570B1 (https=) |
| JP (1) | JP6174563B2 (https=) |
| KR (1) | KR102080151B1 (https=) |
| CN (2) | CN106420767A (https=) |
| AU (1) | AU2012230974B2 (https=) |
| BR (1) | BR112013024168A2 (https=) |
| CA (1) | CA2830515C (https=) |
| DK (1) | DK2688570T3 (https=) |
| ES (1) | ES2561536T3 (https=) |
| MX (1) | MX354409B (https=) |
| SG (1) | SG193380A1 (https=) |
| WO (1) | WO2012129324A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420767A (zh) * | 2011-03-21 | 2017-02-22 | 安德斯有限责任公司 | 用于神经轴突的髓鞘再生的6‑取代的雌二醇衍生物 |
| WO2014064712A2 (en) * | 2012-10-22 | 2014-05-01 | Intas Pharmaceuticals Limited | An improved process for the preparation of fulvestrant |
| SG11201607693WA (en) * | 2014-03-19 | 2016-10-28 | Endece Llc | 6-substituted estradiol derivatives for the treatment of alzheimer's disease |
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136160A (en) * | 1977-08-17 | 1979-01-23 | Cohen Steven R | Specific assay for active demyelinization |
| JPH0193529A (ja) * | 1987-10-05 | 1989-04-12 | Mect Corp | シアロシルコレステロールの脱髄性疾患治療剤 |
| JPH01193529A (ja) | 1988-01-27 | 1989-08-03 | Yoshitsugu Takano | 液体循環装置 |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| BRPI0616639A2 (pt) * | 2005-09-30 | 2011-06-28 | Endece Llc | compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados |
| US8168621B2 (en) * | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
| JP5290189B2 (ja) * | 2006-11-30 | 2013-09-18 | エンディース エルエルシー | ６−アルコキシアルキルエストラジオール誘導体およびその使用 |
| BR112013005843A2 (pt) | 2010-09-14 | 2019-12-10 | Endece Llc | derivativos de er-beta 6-substituído por desmetil-estradiol |
| CN106420767A (zh) * | 2011-03-21 | 2017-02-22 | 安德斯有限责任公司 | 用于神经轴突的髓鞘再生的6‑取代的雌二醇衍生物 |
-
2012
- 2012-03-21 CN CN201610455383.0A patent/CN106420767A/zh active Pending
- 2012-03-21 CN CN201280014512.2A patent/CN103501790B/zh not_active Expired - Fee Related
- 2012-03-21 KR KR1020137027657A patent/KR102080151B1/ko not_active Expired - Fee Related
- 2012-03-21 EP EP12761491.5A patent/EP2688570B1/en not_active Not-in-force
- 2012-03-21 SG SG2013067962A patent/SG193380A1/en unknown
- 2012-03-21 US US13/426,364 patent/US9364486B2/en active Active
- 2012-03-21 JP JP2014501213A patent/JP6174563B2/ja not_active Expired - Fee Related
- 2012-03-21 BR BR112013024168A patent/BR112013024168A2/pt not_active IP Right Cessation
- 2012-03-21 DK DK12761491.5T patent/DK2688570T3/en active
- 2012-03-21 CA CA2830515A patent/CA2830515C/en not_active Expired - Fee Related
- 2012-03-21 WO PCT/US2012/029973 patent/WO2012129324A2/en not_active Ceased
- 2012-03-21 MX MX2013010650A patent/MX354409B/es active IP Right Grant
- 2012-03-21 ES ES12761491.5T patent/ES2561536T3/es active Active
- 2012-03-21 AU AU2012230974A patent/AU2012230974B2/en not_active Ceased
-
2016
- 2016-06-10 US US15/179,349 patent/US9636348B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120245131A1 (en) | 2012-09-27 |
| BR112013024168A2 (pt) | 2017-07-11 |
| EP2688570A2 (en) | 2014-01-29 |
| EP2688570B1 (en) | 2015-11-18 |
| CN103501790A (zh) | 2014-01-08 |
| WO2012129324A9 (en) | 2012-11-15 |
| DK2688570T3 (en) | 2015-12-21 |
| EP2688570A4 (en) | 2014-09-10 |
| SG193380A1 (en) | 2013-10-30 |
| KR20140074253A (ko) | 2014-06-17 |
| WO2012129324A2 (en) | 2012-09-27 |
| AU2012230974A1 (en) | 2013-09-26 |
| JP2014508807A (ja) | 2014-04-10 |
| US9636348B2 (en) | 2017-05-02 |
| CA2830515C (en) | 2015-09-15 |
| MX354409B (es) | 2018-03-05 |
| US20160279144A1 (en) | 2016-09-29 |
| JP6174563B2 (ja) | 2017-08-02 |
| CN106420767A (zh) | 2017-02-22 |
| AU2012230974B2 (en) | 2016-05-12 |
| CA2830515A1 (en) | 2012-09-27 |
| KR102080151B1 (ko) | 2020-02-21 |
| CN103501790B (zh) | 2016-08-17 |
| MX2013010650A (es) | 2013-10-07 |
| US9364486B2 (en) | 2016-06-14 |
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