ES2561418T3 - Eliminación en una sola fase de moléculas no deseadas en la sangre circulante - Google Patents
Eliminación en una sola fase de moléculas no deseadas en la sangre circulante Download PDFInfo
- Publication number
- ES2561418T3 ES2561418T3 ES00930853.7T ES00930853T ES2561418T3 ES 2561418 T3 ES2561418 T3 ES 2561418T3 ES 00930853 T ES00930853 T ES 00930853T ES 2561418 T3 ES2561418 T3 ES 2561418T3
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- blood
- antigens
- hollow fiber
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 84
- 239000008280 blood Substances 0.000 title claims abstract description 84
- 108091007433 antigens Proteins 0.000 claims abstract description 73
- 102000036639 antigens Human genes 0.000 claims abstract description 73
- 239000000427 antigen Substances 0.000 claims abstract description 72
- 239000012528 membrane Substances 0.000 claims abstract description 35
- 239000012510 hollow fiber Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 22
- 239000000835 fiber Substances 0.000 claims abstract description 5
- 230000027455 binding Effects 0.000 claims description 32
- 102000004506 Blood Proteins Human genes 0.000 claims description 7
- 108010017384 Blood Proteins Proteins 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 3
- 238000007385 chemical modification Methods 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 3
- VSUWJVLTQUOKSS-UHFFFAOYSA-N 1-(fluoromethyl)pyridin-1-ium Chemical class FC[N+]1=CC=CC=C1 VSUWJVLTQUOKSS-UHFFFAOYSA-N 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 108090001008 Avidin Proteins 0.000 claims description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 239000000020 Nitrocellulose Substances 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 229920001220 nitrocellulos Polymers 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 229920001971 elastomer Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 14
- 210000000056 organ Anatomy 0.000 description 13
- 230000037361 pathway Effects 0.000 description 13
- 238000000502 dialysis Methods 0.000 description 8
- 210000002381 plasma Anatomy 0.000 description 7
- 238000002054 transplantation Methods 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 238000002616 plasmapheresis Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000003379 elimination reaction Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 230000008030 elimination Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 206010052779 Transplant rejections Diseases 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000007667 floating Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- -1 creatlnine Chemical compound 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 101000588258 Taenia solium Paramyosin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002341 toxic gas Substances 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3493—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate using treatment agents in suspension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- Manufacturing & Machinery (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Water Supply & Treatment (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13740799P | 1999-06-03 | 1999-06-03 | |
| US137407P | 1999-06-03 | ||
| US56651000A | 2000-05-08 | 2000-05-08 | |
| US566510 | 2000-05-08 | ||
| PCT/US2000/040049 WO2000074824A1 (en) | 1999-06-03 | 2000-05-24 | One step removal of unwanted molecules from circulating blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2561418T3 true ES2561418T3 (es) | 2016-02-26 |
Family
ID=26835218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00930853.7T Expired - Lifetime ES2561418T3 (es) | 1999-06-03 | 2000-05-24 | Eliminación en una sola fase de moléculas no deseadas en la sangre circulante |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7744883B2 (enExample) |
| EP (1) | EP1315551B1 (enExample) |
| JP (1) | JP4662665B2 (enExample) |
| AU (1) | AU4860600A (enExample) |
| CA (1) | CA2375112C (enExample) |
| ES (1) | ES2561418T3 (enExample) |
| WO (1) | WO2000074824A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8865172B2 (en) * | 2000-05-08 | 2014-10-21 | Advanced Extravascular Systems, Inc. | Method for reducing the number of unwanted molecules in bodily fluids |
| US20020197252A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Selective adsorption devices and systems |
| AU2003290506A1 (en) * | 2002-04-02 | 2004-04-30 | Scantibodies Laboratory, Inc. | Methods and devices for treating severe peripheral bacterial infections |
| US20040248181A1 (en) * | 2003-06-03 | 2004-12-09 | Stenken Julie A. | Method and kit for enhancing extraction and quantification of target molecules using microdialysis |
| FR2895263B1 (fr) * | 2005-12-26 | 2008-05-30 | Lab Francais Du Fractionnement | Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives |
| WO2010125762A1 (ja) * | 2009-04-30 | 2010-11-04 | 国立大学法人広島大学 | 抗体性拒絶反応抑制剤 |
| WO2013172966A1 (en) * | 2012-05-14 | 2013-11-21 | Children's Medical Center Corporation | Systems and methods for extracorporeal blood modification |
| US9227005B2 (en) | 2013-03-14 | 2016-01-05 | Brian J LeBerthon | Method and device for treating cancer |
| US20150122737A1 (en) * | 2013-11-05 | 2015-05-07 | Angelo Gaitas | Blood cleansing system |
| US20180093032A1 (en) * | 2016-08-15 | 2018-04-05 | Henry John Smith | Targeted apheresis using binding agents or ligands immobilized on membranes |
| BR112020000995A2 (pt) * | 2017-07-17 | 2020-09-08 | Spark Therapeutics, Inc. | métodos e usos de aférese |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4375414A (en) * | 1971-05-20 | 1983-03-01 | Meir Strahilevitz | Immunological methods for removing species from the blood circulatory system and devices therefor |
| JPS554417B2 (enExample) * | 1975-03-11 | 1980-01-30 | ||
| US4581141A (en) * | 1978-02-27 | 1986-04-08 | Purdue Research Foundation | Dialysis material and method for removing uremic substances |
| US4247393A (en) * | 1979-01-11 | 1981-01-27 | Wallace Richard A | Hemodialysis assist device |
| US4787974A (en) * | 1981-06-29 | 1988-11-29 | Ambrus Clara M | Blood purification |
| US4714556A (en) * | 1981-06-29 | 1987-12-22 | Ambrus Clara M | Blood purification |
| CA1221307A (en) * | 1982-12-02 | 1987-05-05 | Nobutaka Tani | Adsorbent and process for preparing the same |
| JPH0611328B2 (ja) * | 1984-10-11 | 1994-02-16 | 株式会社クラレ | 生理活性物質を固定した多孔性中空繊維を使用した液の処理方法 |
| US5061237A (en) * | 1985-07-02 | 1991-10-29 | Cytomed Medizintechnik Gmbh | Method of purifying whole blood |
| US4770774A (en) * | 1985-09-19 | 1988-09-13 | Toray Industries, Inc. | Column for removing β2 -microglobulin |
| US5122112A (en) * | 1986-11-21 | 1992-06-16 | Imre Corporation | Antigen-specific removal of circulating immune complexes |
| JPS63194667A (ja) * | 1987-02-09 | 1988-08-11 | ゾ−マ・コ−ポレ−シヨン | 血漿の処理法およびその生成物 |
| JP2814399B2 (ja) * | 1988-04-04 | 1998-10-22 | 旭メディカル株式会社 | 全血処理用吸着器 |
| JPH06225938A (ja) * | 1993-02-03 | 1994-08-16 | Toray Ind Inc | アレルゲンを固定化した材料およびそれを用いた体外循環システム |
| US5753227A (en) * | 1993-07-23 | 1998-05-19 | Strahilevitz; Meir | Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases |
| WO1996040662A2 (en) * | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| DE19538641C2 (de) * | 1995-10-05 | 2000-09-21 | Privates Inst Bioserv Gmbh | Patientenspezifische Immunadsorber für die extrakorporale Apherese und Verfahren für deren Herstellung |
| US5868936A (en) * | 1996-06-20 | 1999-02-09 | Baxter International Inc. | Affinity membrane system and method of using same |
| US6080404A (en) * | 1997-09-05 | 2000-06-27 | University Of Florida | Materials and methods for removal of substances from fluids |
-
2000
- 2000-05-24 AU AU48606/00A patent/AU4860600A/en not_active Abandoned
- 2000-05-24 ES ES00930853.7T patent/ES2561418T3/es not_active Expired - Lifetime
- 2000-05-24 WO PCT/US2000/040049 patent/WO2000074824A1/en not_active Ceased
- 2000-05-24 JP JP2001501351A patent/JP4662665B2/ja not_active Expired - Fee Related
- 2000-05-24 EP EP00930853.7A patent/EP1315551B1/en not_active Expired - Lifetime
- 2000-05-24 CA CA2375112A patent/CA2375112C/en not_active Expired - Fee Related
-
2004
- 2004-02-13 US US10/778,662 patent/US7744883B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1315551A4 (en) | 2010-05-05 |
| AU4860600A (en) | 2000-12-28 |
| CA2375112C (en) | 2011-04-26 |
| US20040161736A1 (en) | 2004-08-19 |
| WO2000074824A9 (en) | 2002-08-08 |
| CA2375112A1 (en) | 2000-12-14 |
| EP1315551B1 (en) | 2015-11-04 |
| EP1315551A1 (en) | 2003-06-04 |
| WO2000074824A1 (en) | 2000-12-14 |
| JP2004500154A (ja) | 2004-01-08 |
| JP4662665B2 (ja) | 2011-03-30 |
| US7744883B2 (en) | 2010-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8865172B2 (en) | Method for reducing the number of unwanted molecules in bodily fluids | |
| ES2304518T3 (es) | Matriz de afinidad polimerica, un metodo de produccion y uso de la misma. | |
| TW389705B (en) | Affinity membrane system and method of using same | |
| ES2561418T3 (es) | Eliminación en una sola fase de moléculas no deseadas en la sangre circulante | |
| CN101420992B (zh) | 用于体外处理含粒子的液体的可再生过滤器及其应用 | |
| ES2603203T3 (es) | Método y medio para tratar la enfermedad inflamatoria intestinal | |
| US5858238A (en) | Salvage of autologous blood via selective membrane/sorption technologies | |
| ES2894696T3 (es) | Método para la reducción o eliminación de uno o más componentes de un producto sanguíneo | |
| US20130131423A1 (en) | Methods to detect and treat diseases | |
| US20150283318A1 (en) | Methods to detect and treat diseases | |
| CA1198055A (en) | Apparatus and method for therapeutic immunodepletion | |
| CN113226353A (zh) | 治疗与抗中性粒细胞胞质抗体相关的疾病的体外装置和方法 | |
| AU4742500A (en) | Immunoadsorber for use in sepsis therapy | |
| US20190117869A1 (en) | Apparatus and methods to remove toxins from blood by plasmapheresis | |
| US20180093032A1 (en) | Targeted apheresis using binding agents or ligands immobilized on membranes | |
| ES2201125T3 (es) | Metodo para inmunoadsorcion especifica de factores patogenos seleccionados para el tratamiento del sida. | |
| JPH0622633B2 (ja) | 吸着体およびそれを用いた除去装置 | |
| Karoor et al. | Immunoaffinity removal of xenoreactive antibodies using modified dialysis or microfiltration membranes | |
| JPH0260660A (ja) | 体液処理用吸着材 | |
| Frampton et al. | In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients | |
| Lucchiari et al. | In vivo and in vitro optimization of depletion of IgM and IgG xenoantibodies by immunoadsorption using cell membrane proteins | |
| Hout et al. | Specific removal of anti-A and anti-B antibodies by using modified dialysis filters | |
| Weber et al. | Specific blood purification by means of antibody-conjugated magnetic microspheres | |
| Shons et al. | Xenograft rejection mechanisms in man | |
| Hout | Selective antibody removal from blood, plasma and buffer using hollow fiber-based specific antibody filters |