ES255203A1 - Piperazine compounds and methods for their production - Google Patents
Piperazine compounds and methods for their productionInfo
- Publication number
- ES255203A1 ES255203A1 ES0255203A ES255203A ES255203A1 ES 255203 A1 ES255203 A1 ES 255203A1 ES 0255203 A ES0255203 A ES 0255203A ES 255203 A ES255203 A ES 255203A ES 255203 A1 ES255203 A1 ES 255203A1
- Authority
- ES
- Spain
- Prior art keywords
- reacting
- general formula
- prepared
- phenyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0875104/IV (b)/1> together with their acid addition salts and the preparation thereof by reducing a compound of the general formula: <FORM:0875104/IV (b)/2> wherein Y is a methylene or a carbonyl group and, if desired, converting the product into an acid addition salt, wherein R represents an aliphatic hydrocarbon radical containing fewer than 4 carbon atoms, n is 2 or 3, and Ar is phenyl, lower alkyl phenyl, lower alkoxy phenyl or halophenyl (including phenyl radicals containing more than one substituent, and lower indicating one or two carbon atoms in the group so defined) and Y is a methylene or carbonyl group. Compounds of the general formula: <FORM:0875104/IV (b)/3> are prepared by reacting a 1-o-(hydrocarbon substituted)thiophenyl piperazine with an appropriate o -halophenone, ArCO(CH2)n.Hal. Compounds of the general formula: <FORM:0875104/IV (b)/4> are prepared by reacting a 1-o-(hydrocarbon substituted)thiophenylpiperazine with an appropriate aroylalkanoic acid, Ar.CO(CH)n-1COOH or a reactive derivative thereof. 1 - o - Isopropylthiophenylpiperazine is prepared by reacting 2-aminobenzenethiol with isopropyl bromide to give o-iso-propylthio-aniline and reacting this with bis-(b -bromoethyl)amine hydrobromide. Specifications 793,899 and 850,661 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79033559A | 1959-02-02 | 1959-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES255203A1 true ES255203A1 (en) | 1960-08-16 |
Family
ID=38567632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0255203A Expired ES255203A1 (en) | 1959-02-02 | 1960-01-22 | Piperazine compounds and methods for their production |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE587214A (en) |
DE (1) | DE1124953B (en) |
DK (1) | DK95880C (en) |
ES (1) | ES255203A1 (en) |
GB (1) | GB875104A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2836549A (en) * | 1955-01-21 | 1958-05-27 | Elechem Corp | Nickel plating bath containing acetylenic polyamines |
-
1960
- 1960-01-22 ES ES0255203A patent/ES255203A1/en not_active Expired
- 1960-01-30 DK DK36560A patent/DK95880C/en active
- 1960-02-01 GB GB349560A patent/GB875104A/en not_active Expired
- 1960-02-02 BE BE587214A patent/BE587214A/en unknown
- 1960-02-02 DE DE1960P0024364 patent/DE1124953B/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE1124953B (en) | 1962-03-08 |
BE587214A (en) | 1960-08-02 |
DK95880C (en) | 1963-05-06 |
GB875104A (en) | 1961-08-16 |
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