GB875104A - Piperazine compounds and methods for their production - Google Patents

Piperazine compounds and methods for their production

Info

Publication number
GB875104A
GB875104A GB349560A GB349560A GB875104A GB 875104 A GB875104 A GB 875104A GB 349560 A GB349560 A GB 349560A GB 349560 A GB349560 A GB 349560A GB 875104 A GB875104 A GB 875104A
Authority
GB
United Kingdom
Prior art keywords
reacting
general formula
prepared
phenyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB349560A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB875104A publication Critical patent/GB875104A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0875104/IV (b)/1> together with their acid addition salts and the preparation thereof by reducing a compound of the general formula: <FORM:0875104/IV (b)/2> wherein Y is a methylene or a carbonyl group and, if desired, converting the product into an acid addition salt, wherein R represents an aliphatic hydrocarbon radical containing fewer than 4 carbon atoms, n is 2 or 3, and Ar is phenyl, lower alkyl phenyl, lower alkoxy phenyl or halophenyl (including phenyl radicals containing more than one substituent, and lower indicating one or two carbon atoms in the group so defined) and Y is a methylene or carbonyl group. Compounds of the general formula: <FORM:0875104/IV (b)/3> are prepared by reacting a 1-o-(hydrocarbon substituted)thiophenyl piperazine with an appropriate o -halophenone, ArCO(CH2)n.Hal. Compounds of the general formula: <FORM:0875104/IV (b)/4> are prepared by reacting a 1-o-(hydrocarbon substituted)thiophenylpiperazine with an appropriate aroylalkanoic acid, Ar.CO(CH)n-1COOH or a reactive derivative thereof. 1 - o - Isopropylthiophenylpiperazine is prepared by reacting 2-aminobenzenethiol with isopropyl bromide to give o-iso-propylthio-aniline and reacting this with bis-(b -bromoethyl)amine hydrobromide. Specifications 793,899 and 850,661 are referred to.
GB349560A 1959-02-02 1960-02-01 Piperazine compounds and methods for their production Expired GB875104A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79033559A 1959-02-02 1959-02-02

Publications (1)

Publication Number Publication Date
GB875104A true GB875104A (en) 1961-08-16

Family

ID=38567632

Family Applications (1)

Application Number Title Priority Date Filing Date
GB349560A Expired GB875104A (en) 1959-02-02 1960-02-01 Piperazine compounds and methods for their production

Country Status (5)

Country Link
BE (1) BE587214A (en)
DE (1) DE1124953B (en)
DK (1) DK95880C (en)
ES (1) ES255203A1 (en)
GB (1) GB875104A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2836549A (en) * 1955-01-21 1958-05-27 Elechem Corp Nickel plating bath containing acetylenic polyamines

Also Published As

Publication number Publication date
DE1124953B (en) 1962-03-08
BE587214A (en) 1960-08-02
DK95880C (en) 1963-05-06
ES255203A1 (en) 1960-08-16

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