ES2541853T3 - Compuestos basados en sangliferina - Google Patents
Compuestos basados en sangliferina Download PDFInfo
- Publication number
- ES2541853T3 ES2541853T3 ES11704308.3T ES11704308T ES2541853T3 ES 2541853 T3 ES2541853 T3 ES 2541853T3 ES 11704308 T ES11704308 T ES 11704308T ES 2541853 T3 ES2541853 T3 ES 2541853T3
- Authority
- ES
- Spain
- Prior art keywords
- single bond
- represented
- following structure
- bond
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 124
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 69
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 50
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 46
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 38
- 125000003118 aryl group Chemical group 0.000 claims abstract description 37
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 28
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 24
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract description 18
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 14
- 239000001257 hydrogen Substances 0.000 claims abstract description 12
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 10
- 125000000468 ketone group Chemical group 0.000 claims abstract description 10
- 125000005217 alkenylheteroaryl group Chemical group 0.000 claims abstract description 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims abstract description 8
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims abstract description 7
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims abstract description 7
- 125000005843 halogen group Chemical group 0.000 claims abstract description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 31
- -1 2-pyridinyl Chemical group 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 19
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 14
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 10
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 9
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 5
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 10
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1002097.2A GB201002097D0 (en) | 2010-02-09 | 2010-02-09 | Novel compounds |
| GB201002097 | 2010-02-09 | ||
| GB201006128 | 2010-04-13 | ||
| GBGB1006128.1A GB201006128D0 (en) | 2010-04-13 | 2010-04-13 | Novel compounds |
| GBGB1101085.7A GB201101085D0 (en) | 2011-01-21 | 2011-01-21 | Novel compounds |
| GB201101085 | 2011-01-21 | ||
| PCT/GB2011/050236 WO2011098809A1 (en) | 2010-02-09 | 2011-02-09 | Sanglifehrin based compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2541853T3 true ES2541853T3 (es) | 2015-07-27 |
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| ES11704308.3T Active ES2541853T3 (es) | 2010-02-09 | 2011-02-09 | Compuestos basados en sangliferina |
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| EP (1) | EP2533784B1 (enExample) |
| JP (1) | JP5894935B2 (enExample) |
| AU (1) | AU2011214135B2 (enExample) |
| BR (1) | BR112012019866A8 (enExample) |
| CA (1) | CA2788761C (enExample) |
| ES (1) | ES2541853T3 (enExample) |
| MX (1) | MX2012008873A (enExample) |
| WO (1) | WO2011098809A1 (enExample) |
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| GB201008123D0 (en) * | 2010-05-17 | 2010-06-30 | Biotica Tech Ltd | Novel compounds |
| JO3063B1 (ar) * | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
| GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
| BR112019009903A2 (pt) | 2016-11-18 | 2019-08-13 | Neurovive Pharmaceutical Ab | análogo de sangliferina, combinação, composição farmacêutica, e, método para tratamento de um sujeito sofrendo de câncer ou de malignidade de célula-b |
| IL317393A (en) * | 2018-12-21 | 2025-02-01 | Revolution Medicines Inc | Compounds that participate in covalent bonds and their uses |
| MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| IL308195A (en) | 2021-05-05 | 2024-01-01 | Revolution Medicines Inc | RAS inhibitors for cancer treatment |
| PE20240088A1 (es) | 2021-05-05 | 2024-01-16 | Revolution Medicines Inc | Inhibidores de ras |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
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| AR006514A1 (es) | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| CA2259420C (en) | 1996-07-05 | 2007-09-18 | Biotica Technology Limited | Erythromycins and process for their preparation |
| GB9814622D0 (en) | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
| RU2427372C2 (ru) | 2005-06-17 | 2011-08-27 | Новартис Аг | Применение санглиферина для лечения вируса гепатита с |
| CN101616683A (zh) | 2007-01-04 | 2009-12-30 | 德比奥法姆股份有限公司 | 用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素 |
| JP5789190B2 (ja) | 2008-09-24 | 2015-10-07 | シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ | 新規の遺伝子クラスター |
| JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
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- 2011-02-09 EP EP20110704308 patent/EP2533784B1/en not_active Not-in-force
- 2011-02-09 CA CA2788761A patent/CA2788761C/en not_active Expired - Fee Related
- 2011-02-09 AU AU2011214135A patent/AU2011214135B2/en not_active Ceased
- 2011-02-09 JP JP2012552469A patent/JP5894935B2/ja not_active Expired - Fee Related
- 2011-02-09 ES ES11704308.3T patent/ES2541853T3/es active Active
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- 2011-02-09 US US13/575,212 patent/US9119853B2/en active Active
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Also Published As
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|---|---|
| BR112012019866A8 (pt) | 2017-12-26 |
| CA2788761A1 (en) | 2011-08-18 |
| WO2011098809A1 (en) | 2011-08-18 |
| BR112012019866A2 (pt) | 2017-07-11 |
| JP5894935B2 (ja) | 2016-03-30 |
| EP2533784A1 (en) | 2012-12-19 |
| CA2788761C (en) | 2018-05-29 |
| AU2011214135A1 (en) | 2012-08-23 |
| US9119853B2 (en) | 2015-09-01 |
| MX2012008873A (es) | 2012-11-22 |
| US20120295841A1 (en) | 2012-11-22 |
| JP2013518923A (ja) | 2013-05-23 |
| EP2533784B1 (en) | 2015-04-22 |
| CN102770139A (zh) | 2012-11-07 |
| AU2011214135B2 (en) | 2014-07-31 |
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