MX2012008873A - Compuestos a base de sangliferina. - Google Patents
Compuestos a base de sangliferina.Info
- Publication number
- MX2012008873A MX2012008873A MX2012008873A MX2012008873A MX2012008873A MX 2012008873 A MX2012008873 A MX 2012008873A MX 2012008873 A MX2012008873 A MX 2012008873A MX 2012008873 A MX2012008873 A MX 2012008873A MX 2012008873 A MX2012008873 A MX 2012008873A
- Authority
- MX
- Mexico
- Prior art keywords
- single bond
- represented
- following structure
- bond
- compound according
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 127
- 229930185087 sanglifehrin Natural products 0.000 title 1
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 45
- 238000011282 treatment Methods 0.000 claims description 43
- 125000003118 aryl group Chemical group 0.000 claims description 36
- 229910052757 nitrogen Inorganic materials 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- -1 cicioalquenilo Chemical group 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 23
- 125000005842 heteroatom Chemical group 0.000 claims description 23
- 208000015181 infectious disease Diseases 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 15
- 125000000468 ketone group Chemical group 0.000 claims description 14
- 150000002678 macrocyclic compounds Chemical class 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 13
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Landscapes
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB1002097.2A GB201002097D0 (en) | 2010-02-09 | 2010-02-09 | Novel compounds |
| GBGB1006128.1A GB201006128D0 (en) | 2010-04-13 | 2010-04-13 | Novel compounds |
| GBGB1101085.7A GB201101085D0 (en) | 2011-01-21 | 2011-01-21 | Novel compounds |
| PCT/GB2011/050236 WO2011098809A1 (en) | 2010-02-09 | 2011-02-09 | Sanglifehrin based compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012008873A true MX2012008873A (es) | 2012-11-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008873A MX2012008873A (es) | 2010-02-09 | 2011-02-09 | Compuestos a base de sangliferina. |
Country Status (9)
| Country | Link |
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| US (1) | US9119853B2 (enExample) |
| EP (1) | EP2533784B1 (enExample) |
| JP (1) | JP5894935B2 (enExample) |
| AU (1) | AU2011214135B2 (enExample) |
| BR (1) | BR112012019866A8 (enExample) |
| CA (1) | CA2788761C (enExample) |
| ES (1) | ES2541853T3 (enExample) |
| MX (1) | MX2012008873A (enExample) |
| WO (1) | WO2011098809A1 (enExample) |
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| GB201008123D0 (en) * | 2010-05-17 | 2010-06-30 | Biotica Tech Ltd | Novel compounds |
| JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
| GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
| MX2019005349A (es) | 2016-11-18 | 2019-08-05 | Neurovive Pharmaceutical Ab | Uso de analogos de sangliferina macrociclicos como compuestos anticancerigenos. |
| CN113498342A (zh) * | 2018-12-21 | 2021-10-12 | 锐新医药公司 | 参与协同结合的化合物和其用途 |
| CN114786777A (zh) | 2019-11-04 | 2022-07-22 | 锐新医药公司 | Ras抑制剂 |
| EP4214209A1 (en) | 2020-09-15 | 2023-07-26 | Revolution Medicines, Inc. | Indole derivatives as ras inhibitors in the treatment of cancer |
| EP4334325A1 (en) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
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| AR006514A1 (es) | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| EP0909327B1 (en) | 1996-07-05 | 2005-06-01 | Biotica Technology Limited | Erythromycins and process for their preparation |
| GB9814622D0 (en) | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
| WO2006138507A1 (en) | 2005-06-17 | 2006-12-28 | Novartis Ag | Use of sanglifehrin in hcv |
| EP2124992A2 (en) | 2007-01-04 | 2009-12-02 | Debiopharm S.A. | Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy |
| CN102224242B (zh) | 2008-09-24 | 2014-09-24 | 中国科学院上海有机化学研究所 | 新基因簇 |
| JO3063B1 (ar) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
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2011
- 2011-02-09 ES ES11704308.3T patent/ES2541853T3/es active Active
- 2011-02-09 AU AU2011214135A patent/AU2011214135B2/en not_active Ceased
- 2011-02-09 BR BR112012019866A patent/BR112012019866A8/pt not_active Application Discontinuation
- 2011-02-09 WO PCT/GB2011/050236 patent/WO2011098809A1/en not_active Ceased
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- 2011-02-09 CA CA2788761A patent/CA2788761C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2533784B1 (en) | 2015-04-22 |
| CN102770139A (zh) | 2012-11-07 |
| AU2011214135A1 (en) | 2012-08-23 |
| JP5894935B2 (ja) | 2016-03-30 |
| BR112012019866A2 (pt) | 2017-07-11 |
| BR112012019866A8 (pt) | 2017-12-26 |
| AU2011214135B2 (en) | 2014-07-31 |
| US20120295841A1 (en) | 2012-11-22 |
| US9119853B2 (en) | 2015-09-01 |
| EP2533784A1 (en) | 2012-12-19 |
| WO2011098809A1 (en) | 2011-08-18 |
| CA2788761C (en) | 2018-05-29 |
| JP2013518923A (ja) | 2013-05-23 |
| CA2788761A1 (en) | 2011-08-18 |
| ES2541853T3 (es) | 2015-07-27 |
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Owner name: NEUROVIVE PHARMACEUTICAL AB |
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| FG | Grant or registration |