ES2539843A1 - Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas - Google Patents
Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas Download PDFInfo
- Publication number
- ES2539843A1 ES2539843A1 ES201331666A ES201331666A ES2539843A1 ES 2539843 A1 ES2539843 A1 ES 2539843A1 ES 201331666 A ES201331666 A ES 201331666A ES 201331666 A ES201331666 A ES 201331666A ES 2539843 A1 ES2539843 A1 ES 2539843A1
- Authority
- ES
- Spain
- Prior art keywords
- separation
- translation
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title abstract 4
- 238000000926 separation method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000004159 blood analysis Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- B03C5/022—Non-uniform field separators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0663—Stretching or orienting elongated molecules or particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Fluid Mechanics (AREA)
- Electrochemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- External Artificial Organs (AREA)
Abstract
Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas. El dispositivo comprende al menos un canal de transporte (1) que utiliza varios principios fluido-hidrodinámicos para incrementar la cantidad de fluido separado/obtenido; al menos un área de separación (2) que divide parte del fluido que circula por el canal de transporte hacia un como mínimo un canal de recogida (3) o cámara de reacción. El área de separación (2) puede incluir al menos una agrupación de pilares, la configuración de los cuales maximiza la cantidad extraída de fluido en el mismo tiempo. El canal de recogida (3) tiene una profundidad y un ancho adaptables según la necesidad del test que se vaya a implementar. En particular, la invención proporcionar un filtro para separar plasma de una gota de sangre con gran eficiencia, que puede ser utilizado en sistemas portátiles de análisis sanguíneo.
Description
Claims (1)
-
imagen1 imagen2
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201331666A ES2539843B2 (es) | 2013-11-15 | 2013-11-15 | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
PCT/ES2014/070833 WO2015071515A1 (es) | 2013-11-15 | 2014-11-11 | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
EP14861638.6A EP3070471A4 (en) | 2013-11-15 | 2014-11-11 | Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy |
US15/154,937 US10041931B2 (en) | 2013-11-15 | 2016-05-13 | Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201331666A ES2539843B2 (es) | 2013-11-15 | 2013-11-15 | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2539843A1 true ES2539843A1 (es) | 2015-07-06 |
ES2539843B2 ES2539843B2 (es) | 2015-11-16 |
Family
ID=53056824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201331666A Active ES2539843B2 (es) | 2013-11-15 | 2013-11-15 | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
Country Status (4)
Country | Link |
---|---|
US (1) | US10041931B2 (es) |
EP (1) | EP3070471A4 (es) |
ES (1) | ES2539843B2 (es) |
WO (1) | WO2015071515A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2539843B2 (es) | 2013-11-15 | 2015-11-16 | Universitat Politècnica De Catalunya | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
JP7003350B6 (ja) * | 2015-12-11 | 2022-01-28 | パリ シアンス エ レットル | 二相性気体/液体プラズマ反応器 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007071989A1 (en) * | 2005-12-21 | 2007-06-28 | Oxford Biosensors Limited | Micro-fluidic structures |
WO2009140326A2 (en) * | 2008-05-16 | 2009-11-19 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids |
US20110011781A1 (en) * | 2008-02-27 | 2011-01-20 | Boehringer Ingelheim Microparts Gmbh | Apparatus for the separation of plasma |
WO2012125723A2 (en) * | 2011-03-14 | 2012-09-20 | The University Of North Carolina At Chapel Hill | Microfluidic nitric oxide sensor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69619400T2 (de) * | 1995-06-16 | 2002-09-26 | Univ Washington Seattle | Flacher mikrogefertigter querstromfilter für flüssigkeiten |
US7743928B2 (en) * | 2002-09-07 | 2010-06-29 | Timothy Crowley | Integrated apparatus and methods for treating liquids |
DE10313201A1 (de) * | 2003-03-21 | 2004-10-07 | Steag Microparts Gmbh | Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält |
KR20050096489A (ko) | 2004-03-31 | 2005-10-06 | 주식회사 올메디쿠스 | 혈액 내 혈구를 평면상의 기판에서 특별한 전기, 자기적인장치없이 분리 및 이송할 수 있는 필터 |
ES2539843B2 (es) | 2013-11-15 | 2015-11-16 | Universitat Politècnica De Catalunya | Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas |
-
2013
- 2013-11-15 ES ES201331666A patent/ES2539843B2/es active Active
-
2014
- 2014-11-11 WO PCT/ES2014/070833 patent/WO2015071515A1/es active Application Filing
- 2014-11-11 EP EP14861638.6A patent/EP3070471A4/en not_active Withdrawn
-
2016
- 2016-05-13 US US15/154,937 patent/US10041931B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007071989A1 (en) * | 2005-12-21 | 2007-06-28 | Oxford Biosensors Limited | Micro-fluidic structures |
US20110011781A1 (en) * | 2008-02-27 | 2011-01-20 | Boehringer Ingelheim Microparts Gmbh | Apparatus for the separation of plasma |
WO2009140326A2 (en) * | 2008-05-16 | 2009-11-19 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids |
WO2012125723A2 (en) * | 2011-03-14 | 2012-09-20 | The University Of North Carolina At Chapel Hill | Microfluidic nitric oxide sensor |
Also Published As
Publication number | Publication date |
---|---|
ES2539843B2 (es) | 2015-11-16 |
US20160258928A1 (en) | 2016-09-08 |
EP3070471A1 (en) | 2016-09-21 |
WO2015071515A1 (es) | 2015-05-21 |
US10041931B2 (en) | 2018-08-07 |
EP3070471A4 (en) | 2017-07-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1117944T1 (el) | Συνθετη δειγματοληψια ρευστων | |
BR112015022738A8 (pt) | métodos e dispositivos para coleta e separação de amostras | |
EA201590285A1 (ru) | Способ и система для ориентирования и/или сортировки микрофлюидных частиц | |
MX369055B (es) | Dispositivo de recogida de fluidos biológicos y sistema de recogida y ensayo de fluidos biológicos. | |
TR201900687T4 (tr) | Sivi numune alicisi, parça ki̇ti̇ ve bi̇rleşti̇rmeye yöneli̇k yöntem | |
MX2015014477A (es) | Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos. | |
MX365006B (es) | Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos. | |
EA201892084A1 (ru) | Способы и системы для обработки клеточной культуры | |
WO2012138882A3 (en) | Micro-fluidic system using micro-apertures for high throughput detection of cells | |
MX2017003454A (es) | Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes. | |
EA202090686A3 (ru) | Система отделения твердых частиц, отмывки и отбора проб | |
MX2015014484A (es) | Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos. | |
WO2014152643A3 (en) | Microfluidic microbe detection and isolation | |
MX2016012658A (es) | Detector de entrada y metodo de muestreo. | |
CY1117533T1 (el) | Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη | |
MX2016011474A (es) | Metodos y dispositivos para recoleccion de muestras y separacion de muestras. | |
CL2014002372A1 (es) | Un aparato de separacion que separa la materia particulada en base a la densidad de un proceso de molieda, incluye un alojamiento, una entrada de particulas, una entrada de fluido, una primera y una segunda salida; un dispositivo; un molino de husillo; y metodo asociado. | |
UY31720A1 (es) | Procedimiento y aparato para separar particulas en un fluido | |
WO2013079927A3 (en) | Air sampling device | |
MX2020003018A (es) | Desgasificación y análisis del fluido de perforación. | |
MX2017010900A (es) | Refinamiento de liquidos. | |
EP3782730A3 (en) | Depth filtration device for separating specimen phases | |
MX2015014482A (es) | Dispositivo de separacion de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos. | |
MX2016009484A (es) | Centrifuga compacta de alta velocidad para utilizarse con pequeños volumenes de muestra. | |
MY184494A (en) | Condensate-gas rations of hydrocarbon-containing fluids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2539843 Country of ref document: ES Kind code of ref document: B2 Effective date: 20151116 |