ES2539186T3 - Células madre estromales - Google Patents

Células madre estromales Download PDF

Info

Publication number
ES2539186T3
ES2539186T3 ES13707295.5T ES13707295T ES2539186T3 ES 2539186 T3 ES2539186 T3 ES 2539186T3 ES 13707295 T ES13707295 T ES 13707295T ES 2539186 T3 ES2539186 T3 ES 2539186T3
Authority
ES
Spain
Prior art keywords
cells
cell
population
human
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13707295.5T
Other languages
English (en)
Spanish (es)
Inventor
Stephen Joseph ELLIMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orbsen Therapeutics Ltd
Original Assignee
Orbsen Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orbsen Therapeutics Ltd filed Critical Orbsen Therapeutics Ltd
Application granted granted Critical
Publication of ES2539186T3 publication Critical patent/ES2539186T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0669Bone marrow stromal cells; Whole bone marrow
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
ES13707295.5T 2012-02-10 2013-02-11 Células madre estromales Active ES2539186T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201202319 2012-02-10
GBGB1202319.8A GB201202319D0 (en) 2012-02-10 2012-02-10 Stromal stem cells
PCT/EP2013/052692 WO2013117761A1 (en) 2012-02-10 2013-02-11 Stromal stem cells

Publications (1)

Publication Number Publication Date
ES2539186T3 true ES2539186T3 (es) 2015-06-26

Family

ID=45929927

Family Applications (3)

Application Number Title Priority Date Filing Date
ES13707295.5T Active ES2539186T3 (es) 2012-02-10 2013-02-11 Células madre estromales
ES18190005T Active ES2959833T3 (es) 2012-02-10 2013-02-11 Métodos para obtener células madre estromales
ES15158384T Active ES2697780T3 (es) 2012-02-10 2013-02-11 Métodos para obtener células madre estromales

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES18190005T Active ES2959833T3 (es) 2012-02-10 2013-02-11 Métodos para obtener células madre estromales
ES15158384T Active ES2697780T3 (es) 2012-02-10 2013-02-11 Métodos para obtener células madre estromales

Country Status (22)

Country Link
US (10) US11230700B2 (https=)
EP (4) EP3492584B1 (https=)
JP (1) JP5829765B2 (https=)
KR (1) KR102124837B1 (https=)
CN (1) CN104302763B (https=)
AU (1) AU2013217870B2 (https=)
BR (1) BR112014019277A8 (https=)
CA (1) CA2863821C (https=)
CY (1) CY1116365T1 (https=)
DK (1) DK2758523T3 (https=)
ES (3) ES2539186T3 (https=)
GB (1) GB201202319D0 (https=)
HR (1) HRP20150594T1 (https=)
HU (1) HUE026480T2 (https=)
IN (1) IN2014KN01777A (https=)
PL (1) PL2758523T3 (https=)
PT (1) PT2758523E (https=)
RS (1) RS54073B1 (https=)
RU (1) RU2636551C2 (https=)
SI (1) SI2758523T1 (https=)
SM (1) SMT201500147B (https=)
WO (1) WO2013117761A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201202319D0 (en) 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
WO2014170411A1 (en) 2013-04-16 2014-10-23 Orbsen Therapeutics Limited Medical use of syndecan-2
EP3074506A1 (en) 2014-02-12 2016-10-05 National University of Ireland, Galway Selection and use of stem cells
KR101690872B1 (ko) 2014-08-19 2016-12-29 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법
US9716660B2 (en) * 2014-12-11 2017-07-25 Intel Corporation Hierarchical enforcement of service flow quotas
KR101686315B1 (ko) 2015-01-09 2016-12-13 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 슈반 세포의 분화 방법
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
WO2016154019A1 (en) * 2015-03-20 2016-09-29 Orbsen Therapeutics Limited Modulators of syndecan-2 and uses thereof
EP3922253A1 (en) 2016-01-15 2021-12-15 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
CN106177918A (zh) * 2016-09-30 2016-12-07 广州赛莱拉干细胞科技股份有限公司 一种间充质干细胞注射液及其制备方法和应用
WO2018220442A2 (en) * 2017-05-30 2018-12-06 Orbsen Therapeutics Limited Stromal stem cell therapeutics and methods of use
JP7174758B2 (ja) * 2017-07-14 2022-11-17 オーブセン セラピューティクス リミテッド Cd39間質幹細胞の単離方法と使用
AU2020353000A1 (en) * 2019-09-23 2022-04-07 The Trustees Of The University Of Pennsylvania Disrupting tumor tissues by targeting fibroblast activation protein (FAP)
WO2021061708A1 (en) * 2019-09-23 2021-04-01 The Trustees Of The Univeristy Of Pennsylvania Monoclonal antibody against canine fibroblast activation protein that cross-reacts with mouse and human fibroblast activation protein (fap)
WO2022179518A1 (en) * 2021-02-25 2022-09-01 Rosas Ivan O Anti-fibrotic peptides and uses thereof
CN116334214A (zh) * 2023-04-04 2023-06-27 暨南大学附属第一医院(广州华侨医院) 一种用于急性心肌梗死和稳定性心绞痛鉴别的生物标志物的ceRNA调控网络及其应用
IT202300007497A1 (it) * 2023-04-18 2024-10-18 Comecer Spa Isolatore per colture cellulari derivate da un tessuto perinatale e metodo di isolamento di almeno una tipologia di cellule da un tessuto perinatale

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1012403A (en) 1911-01-23 1911-12-19 Thomas W Mcneill Smoke-indicator.
US5486599A (en) 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5726058A (en) 1992-12-01 1998-03-10 Jalkanen; Markku Syndecan stimulation of cellular differentiation
AU2340397A (en) 1996-03-21 1997-10-10 Mayo Foundation For Medical Education And Research Use of nicotine to treat liver disease
AU749675B2 (en) * 1998-03-13 2002-07-04 Mesoblast International Sarl Uses for human non-autologous mesenchymal stem cells
PT1082410E (pt) 1998-05-29 2007-11-09 Osiris Therapeutics Inc Células estaminais mesenquimatosas humanas cd45+ e/ou fibroblastos+
DE60143517D1 (de) 2000-04-25 2011-01-05 Osiris Therapeutics Inc Wiederherstellung der gelenken mit mesenchymalen stammzellen
US7442390B2 (en) * 2000-06-05 2008-10-28 University Of South Florida Method for enhancing engraftment of cells using mesenchymal progenitor cells
WO2002087609A1 (en) 2001-05-01 2002-11-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Identification of a cell surface receptor for papillomaviruses
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
AU2003214857A1 (en) 2002-01-18 2003-09-02 Regents Of The University Of Minnesota Syndecans and angiogenesis
CA2490261A1 (en) 2002-06-27 2004-01-08 The University Of Queensland Differentiation modulating agents and uses therefor
WO2004052177A2 (en) * 2002-12-05 2004-06-24 Case Western Reserve University Cell-based therapies for ischemia
JP2007531707A (ja) 2003-10-15 2007-11-08 ピーディーエル バイオファーマ, インコーポレイテッド IGの重鎖定常領域の位置250、314および/または428の変異誘発によるFc融合タンパク質血清半減期の改変
EP2298864B1 (en) 2004-03-22 2017-10-11 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
KR101322889B1 (ko) * 2004-08-16 2013-10-30 셀리서치 코포레이션 피티이 리미티드 제대의 양막으로부터 줄기/전구세포의 추출
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
US11268149B2 (en) 2004-12-08 2022-03-08 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
JP5283219B2 (ja) 2006-04-20 2013-09-04 学校法人自治医科大学 ベクター産生型腫瘍標的細胞
US20070264239A1 (en) 2006-05-10 2007-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Isolation of pericytes
WO2008085229A2 (en) 2006-11-15 2008-07-17 Arteriocyte Inc. Cell-based therapies for treating liver disease
US20080131415A1 (en) 2006-11-30 2008-06-05 Riddell Stanley R Adoptive transfer of cd8 + t cell clones derived from central memory cells
KR100883565B1 (ko) 2007-02-14 2009-02-13 (주)프로스테믹스 지방 줄기세포의 조직 재생 능력을 최적화한 조건 배지를 함유한 조직 재생용 주사제 첨가제
US20100111914A1 (en) 2007-05-21 2010-05-06 Yuanyuan Zhang Stem cells from urine and methods for using the same
KR20080103637A (ko) * 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
WO2009012357A2 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
US20100247577A1 (en) 2007-10-17 2010-09-30 Txcell Tr1 cells, mesenchymal stem cells and uses thereof
CA2713156A1 (en) * 2008-02-04 2009-08-13 Bipar Sciences, Inc. Methods of diagnosing and treating parp-mediated diseases
US20090220588A1 (en) 2008-02-21 2009-09-03 Massachusetts Institute Of Technology Simultaneous Delivery of Receptors and/or Co-Receptors for Growth Factor Stability and Activity
KR20100106744A (ko) 2009-03-24 2010-10-04 이화여자대학교 산학협력단 이동성 피부세포질환 또는 멜라닌 합성관련 질환 예방 또는치료용 조성물
JP5727458B2 (ja) 2009-04-13 2015-06-03 アプセト ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフトApceth Gmbh & Co. Kg 改変間葉系幹細胞及びそれを使用した腫瘍の治療方法
KR101301262B1 (ko) 2009-10-23 2013-08-27 가톨릭대학교 산학협력단 TGFβ를 코딩하는 뉴클레오티드 서열이 도입된 간엽줄기세포 및 그의 용도
KR101622650B1 (ko) 2009-12-31 2016-06-01 엘지디스플레이 주식회사 액정 전계 렌즈 및 이를 이용한 입체 표시 장치
CA2792802C (en) 2010-03-10 2017-10-31 Two Cells Co., Ltd. Cell preparation containing mesenchymal stem cells, and method for producing same
US20130189275A1 (en) 2010-06-03 2013-07-25 University Of Rochester Compositions and methods for inhibition of or treatment of dengue virus infection
CA2802880C (en) 2010-06-18 2019-09-24 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Hair follicle neogenesis
KR101309910B1 (ko) 2010-08-06 2013-09-17 이화여자대학교 산학협력단 대장암 진단 및 치료제로서의 신데칸-2 펩티드 단편
KR101317507B1 (ko) 2010-08-30 2013-10-15 가톨릭대학교 산학협력단 레바미피드를 유효성분으로 포함하는 암 또는 면역질환의 예방 또는 치료용 조성물
CN103261407B (zh) * 2010-12-22 2016-03-02 杜兰教育基金委员会 用于识别和培养具有高度增殖潜能的多能间充质干细胞的方法
KR20120095022A (ko) 2011-02-18 2012-08-28 가톨릭대학교 산학협력단 간엽줄기세포 및 면역조절 t 세포를 유효성분으로 포함하는 이식편대숙주질환 예방 또는 치료용 세포치료제 조성물
CA2829586C (en) 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
KR101145406B1 (ko) * 2011-07-06 2012-05-15 (주)지노믹트리 장암 진단을 위한 장암 특이적 메틸화 마커 유전자의 메틸화 검출방법
GB201202319D0 (en) 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
US20150030615A1 (en) * 2012-03-09 2015-01-29 Verastem, Inc. Biomarkers for cancer stem cells and related methods of use
EP2850178A4 (en) 2012-05-18 2015-10-28 Agency Science Tech & Res EXOSOMES OF MESHCHYMIC STROKE CELL OF UMBILICAL CORD
AU2014251388B2 (en) 2013-04-12 2017-03-30 Evox Therapeutics Limited Therapeutic delivery vesicles
WO2014170411A1 (en) 2013-04-16 2014-10-23 Orbsen Therapeutics Limited Medical use of syndecan-2
SG11201601939VA (en) 2013-09-16 2016-04-28 Agency Science Tech & Res Method
WO2015088414A1 (en) 2013-12-13 2015-06-18 Isletone Ab Immunomodulatory compositions
CN106659742B (zh) 2014-08-18 2021-09-03 埃普塞斯有限责任两合公司 表达免疫应答刺激细胞因子以吸引和/或激活免疫细胞的基因修饰间充质干细胞
GB201418562D0 (en) 2014-10-20 2014-12-03 Univ London Queen Mary Peptides
MX2017004742A (es) 2014-10-20 2017-07-20 Nestec Sa Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos.
WO2016154019A1 (en) 2015-03-20 2016-09-29 Orbsen Therapeutics Limited Modulators of syndecan-2 and uses thereof
EP3922253A1 (en) 2016-01-15 2021-12-15 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
DK3416964T3 (da) 2016-02-19 2021-02-22 Phoenix Molecular Designs 6-Oxo-N-(1-(benzyl)-1H-pyrazol-4-YL)-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-A]pyrazin-2-carboxamid-derivater som P90 ribosomal S6 kinase- (RSK-) hæmmere til behandling af cancer
WO2018220442A2 (en) 2017-05-30 2018-12-06 Orbsen Therapeutics Limited Stromal stem cell therapeutics and methods of use
JP7174758B2 (ja) 2017-07-14 2022-11-17 オーブセン セラピューティクス リミテッド Cd39間質幹細胞の単離方法と使用
MX2021000184A (es) 2018-07-05 2021-05-12 Novobind Livestock Therapeutics Inc Anticuerpos contra agentes patogenos en aves de corral y sus aplicaciones.
WO2021038289A1 (en) 2019-08-23 2021-03-04 Orbsen Therapeutics Limited Compositions for monocyte and macrophage polarization and methods of use

Also Published As

Publication number Publication date
RS54073B1 (sr) 2015-10-30
CN104302763A (zh) 2015-01-21
US20240209319A1 (en) 2024-06-27
EP3492584B1 (en) 2023-07-19
ES2697780T3 (es) 2019-01-28
KR20140143363A (ko) 2014-12-16
US10907131B2 (en) 2021-02-02
KR102124837B1 (ko) 2020-06-22
HRP20150594T1 (hr) 2015-07-17
PL2758523T3 (pl) 2015-08-31
BR112014019277A8 (pt) 2017-07-11
PT2758523E (pt) 2015-07-21
EP2902482A1 (en) 2015-08-05
US20220090019A1 (en) 2022-03-24
ES2959833T3 (es) 2024-02-28
US11952589B2 (en) 2024-04-09
CA2863821C (en) 2023-09-19
US20230313142A1 (en) 2023-10-05
EP2758523A1 (en) 2014-07-30
CY1116365T1 (el) 2017-02-08
US11230700B2 (en) 2022-01-25
US11142747B2 (en) 2021-10-12
US20220112466A1 (en) 2022-04-14
US20160215265A1 (en) 2016-07-28
US10920197B2 (en) 2021-02-16
JP5829765B2 (ja) 2015-12-09
US20230323307A1 (en) 2023-10-12
WO2013117761A1 (en) 2013-08-15
US11926848B2 (en) 2024-03-12
US11952590B2 (en) 2024-04-09
RU2636551C2 (ru) 2017-11-23
IN2014KN01777A (https=) 2015-10-23
GB201202319D0 (en) 2012-03-28
AU2013217870A1 (en) 2014-09-11
JP2015509360A (ja) 2015-03-30
SI2758523T1 (sl) 2015-10-30
US20230332106A1 (en) 2023-10-19
HUE026480T2 (en) 2016-06-28
EP4257203A2 (en) 2023-10-11
US20200078413A1 (en) 2020-03-12
SMT201500147B (it) 2015-09-07
US11434471B2 (en) 2022-09-06
AU2013217870B2 (en) 2018-11-08
CN104302763B (zh) 2017-08-29
RU2014136711A (ru) 2016-03-27
EP4257203A3 (en) 2024-05-15
US20150037292A1 (en) 2015-02-05
EP2902482B1 (en) 2018-09-19
CA2863821A1 (en) 2013-08-15
BR112014019277A2 (https=) 2017-06-20
US20180298341A1 (en) 2018-10-18
EP2758523B1 (en) 2015-03-11
DK2758523T3 (da) 2015-06-22
US11884936B2 (en) 2024-01-30
EP3492584A1 (en) 2019-06-05

Similar Documents

Publication Publication Date Title
ES2539186T3 (es) Células madre estromales
TR201809635T4 (tr) Osteoblastik fonksiyonun arttırılmasına yönelik yöntemler.
HK40099502A (en) Methods of obtaining stromal stem cells
HK40003604A (en) Methods of obtaining stromal stem cells
HK40003604B (en) Methods of obtaining stromal stem cells
Suresh Growth factor priming of murine mesenchymal stem cells critically determines their functionality
Gregory Mesenchymal Stem Cells